Find information on thousands of medical conditions and prescription drugs.

Fibrodysplasia ossificans progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disorder of the connective tissue, in which fibrous tissue (including muscle, tendon, and ligament) is ossified and slowly turned into bone. This occurs when the fibrous tissue is damaged and is replaced with bone tissue, because the body's repair mechanism is mutated. These bony growths occur painfully and slowly over a period of weeks or months, and usually begin in the upper back and shoulders. FOP bones are not usually removed with surgery because that causes the body to "repair" the area of surgery with more bones. Over time, as more FOP bones grow and joints get stiffer, it becomes more difficult to walk, eat, and even breathe. more...

Home
Diseases
A
B
C
D
E
F
Fabry's disease
Facioscapulohumeral...
Factor V Leiden mutation
Factor VIII deficiency
Fallot tetralogy
Familial adenomatous...
Familial Mediterranean fever
Familial periodic paralysis
Familial polyposis
Fanconi syndrome
Fanconi's anemia
Farber's disease
Fascioliasis
Fatal familial insomnia
Fatty liver
Febrile seizure
Fibrodysplasia ossificans...
Fibromatosis
Fibrosarcoma
Fibrosis
Fibrous dysplasia
Filariasis
Fissured tongue
Fitz-Hugh-Curtis syndrome
Flesh eating bacteria
Fluorosis
Focal dystonia
Foix-Alajouanine syndrome
Follicular lymphoma
Fountain syndrome
Fragile X syndrome
Fraser syndrome
FRAXA syndrome
Friedreich's ataxia
Frontotemporal dementia
Fructose intolerance
Fructose-1,6-bisphosphatase...
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

Children born with FOP have a characteristic shortening of the great toe. Their first "flare-up" that leads to the formation of FOP bones is usually before the age of 10. Sometimes after a flare-up is over there is no new noticeable FOP bone. It is important that people with FOP do not participate in strenuous activity, and they should try to avoid falling or getting bruises, because those things can cause more FOP bones to grow. People with FOP should never allow anyone to try to stretch out their joints or bend them more than they can go on their own. However, sometimes flare-ups happen for no apparent reason, so being careful is not a guarantee of health.

FOP is caused by an autosomal dominant allele on chromosome 4. There have been fewer than 200 cases reported, but a study found that it affects approximately 1 in 1.64 million people. Most cases are caused by spontaneous mutation in the gametes, because most people with FOP cannot have children. However, the allele has varying expressivity, but complete penetrance (i.e. it always affects the bearer, but its effects are variable). A similar, but less catastrophic disease is Fibrous dysplasia, which is caused by a postzygotic mutation.

Sources

  • The International FOP Association
  • "Fibrodysplasia ossificans progressiva" eMedicine
  • "Fibrodysplasia ossificans progressiva" WebMDHealth

Read more at Wikipedia.org


[List your site here Free!]


Dateline USA
From Office World News, 1/1/99

Pinnacle, a Toshiba dealer, donates copier to benefit

7-year-old SANTA MARIA, CA-Pinnacle Office Systems, a Santa Maria-based Toshiba copier and fax dealership, is co-sponsoring a campaign to benefit Stephanie Snow, who suffers a rare disorder, Fibrodysplasia Ossificans Progressiva (FOP).

Bob and Jennifer Snow, parents of Stephanie, and Pinnacle president Mike Mitchell have been selling raffle tickets throughout the Santa Maria area and on April 17, 1999, a drawing will be held at the annual Santa Maria barbecue. The top prize is a Toshiba 2860 copier, which is being donated by Pinnacle. Funds raised will be donated to the International Fibrodysplasia Ossificans Progressiva Association (IFOPA).

IFOPA, a non-profit organization, supports education, communication and medical research for the rare genetic disorder that causes bone to form in muscles and other connective tissues. Currently, there is no treatment or cure. For more information, call Bob Snow. (805) 937-1420.

Friend of the Agency Award to Fonteyn

A $5,000 scholarship fund in the name of Frank Fonteyn was announced at a reception honoring Fonteyn for his 35 years work on behalf of the office equipment industry through BTA and, before that, NOMDA. The scholarship fund was established by Hunter Barth Inc. of Costa Mesa, CA, a marketing and advertising firm that has been closely aligned with the office products industry.

"Frank Fonteyn is a visionary and catalyst for action, causing a positive chain reaction of results. He helped us fulfill our firm's vision to be a powerful and recognizable marketing force, improving quality of life, and he's done that for so many individuals, companies and organizations," Hunter Barth founder, Paul Barth told the assembled crowd at the BTA Conference Center in Kansas City, MO.

Frank Fonteyn, sixty, began his career selling for Kennedy Office Machines in San Jose, CA after his discharge from the Navy at the end of WWII. He ultimately became a principal in the firm while also becoming a driving force in the office equipment industry. In 1990, he joined BTA full time, helping dealers through educational programs, manufacturer relations, political action efforts and overseeing the BTA (NOMDA) trade show. In the words of long time BTA legal counsel, Robert Goldberg, who emceed the reception, "No one has given more or done more for the industry than Frank Fonteyn."

The Frank Fonteyn scholarship fund was awarded as part of Hunter Barth's "Official Friend of the Agency Program" acknowledging those who make a recognizable and powerful contribution improving quality of life. Given the opportunity to establish it at any school, Fonteyn chose Avila College, a 1500 student liberal arts institution near BTA in Kansas City. Tim Barry, vice president of Avila College said, "Over the past nine years, Frank has become a dear friend to Avila College and to me personally. My heartfelt thanks to Frank and Hunter Barth Inc. for this enlightened gift-it will powerfully improve quality of life."

Copyright B U S Publishing Group, Inc. Jan 1999
Provided by ProQuest Information and Learning Company. All rights Reserved

Return to Fibrodysplasia ossificans progressiva
Home Contact Resources Exchange Links ebay