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Fibrous dysplasia

Fibrous dysplasia is a disease that causes growths or lesions in one or more bones of the human body. These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone(s) can be involved. Many patients have lesions localized in only one bone (70-80%), but others have them in many bones. In many cases, people suffering from fibrous dysplasia also have endocrine diseases and skin pigmentation; the three together constitute McCune-Albright syndrome. more...

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Fibrous dysplasia is very rare, not much is known about it, and there is no known cure. However, it is known that it is caused by a genetic mutation that occurs sometime during fetal development, and is not hereditary.

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Fibrous dysplasia of the temporal bone - Brief Article
From Ear, Nose & Throat Journal, 11/1/00 by Christian Deguine

The otoscopic view is that of a left ear canal in a 24-year-old man. A hard, slow-growing, bone-like mass is seen extending from the superior external auditory canal wall. Only a small slit of the external canal opening remains at the inferior edge of the canal. Treatment involves the repeated conservative surgical excision of the obstructing fibrous dysplasia and of abnormal bone within the external auditory canal and, in some cases, also in the middle ear. Repeated surgery is required as needed every few months or years, depending on the rate of growth.

From Gap, France (Dr. Deguine). From the Pulec Ear Clinic, Los Angeles (Dr. Pulec).

COPYRIGHT 2000 Medquest Communications, Inc.
COPYRIGHT 2001 Gale Group

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