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Shock

In medicine, shock (hypoperfusion) is a life-threatening medical emergency characterized by inability of the circulatory system to supply enough oxygen to meet tissue requirements. Hypotension is usually, though not always, present. Without prompt medical treatment, shock usually causes death. more...

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Medicines

Types of shock

  • Hypovolemic shock. The single most common cause of shock is blood volume loss, resulting from a serious wound or a severe burn leading to hypovolemic shock. This may also be referred to as haemmorhagic shock.
  • Cardiogenic shock is caused by the failure of the heart to pump effectively. This can be due to damage to the heart muscle, most often from a large myocardial infarction. Other causes of cardiogenic shock include arrhythmias, or cardiac valve problems.
  • Distributive shock. As in hypovolemic shock there is an insufficient volume of blood. This form of relative hypovolaemia is the result of dilation of bloodvessels. Examples of this form of shock are:
    • Septic shock is caused by overwhelming infection leading to vasodilation. It is treated by antibiotics, fluid replacement, and vasoconstrictors.
    • Acute adrenal insufficiency is not infrequently the result of discontinuing corticosteroid treatment without tapering the dosage.
    • Less commonly severe anaphylactic reactions may cause anaphylactic shock as allergens trigger widespread vasodilation and movement of fluid out of the blood into the tissues.
    • The rarest cause of shock is acute spinal cord injury leading to neurogenic shock. Neurogenic shock is caused by the sudden loss of the sympathetic nervous system signals to the smooth muscle in vessel walls. Without this constant stimulation the vessels relax resulting in a sudden decrease in peripheral vascular resistance and decreased blood pressure.
  • Obstructive shock. Hereby the flow of blood is obstructed. Several conditions result in this form of shock.
    • Cardiac tamponade, in which blood in the pericardium prevents inflow of blood into the heart (venous return). Or constrictive pericarditis which has the same effect.
    • Tension pneumothorax. Through increased intrathoracic pressure bloodflow to the heart is prevented (venous return).
    • Massive pulmonary embolism is the result of a thromboembolic incident in bloodvessels of the lungs and hinders the return of blood to the heart.

Symptoms and signs

The external signs and symptoms of shock are:

  • feeling of thickness, weakness, thirst;
  • pallor, especially visible at the inner side of the lips when the casualty has a dark skin;
  • rapid pulse (tachycardia, more than 120 beats per minute), the radial pulse is difficult to feel;
  • when pressing a finger nail, it takes more than two seconds for the color to come back;
  • confusion or anxiety;

Other signs can be evaluated:

  • decreased urine production
  • low blood pressure.

Patients with hypovolaemic or cardiogenic shock will have cold and clammy hands and feet. Septic, anaphylactic and neurogenic shock may present with warm extremities.

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Autonomic nervous system-based early goal directed therapy in the treatment of severe sepsis and septic shock: preliminary evidence
From CHEST, 10/1/05 by William C. Shoemaker

PURPOSE: To investigate the clinical efficacy of early goal-directed therapy based on autonomic nervous system (ANS) monitoring (noninvasive, simultaneous, independent measures of sympathetic (SNS) and parasympathetic nervous system (PSNS) activity) in patients with severe sepsis and septic shock.

METHODS: 208 severe sepsis and septic shock patients were studied in an urban, level 1 university-run trauma service.: ANS monitoring measured the sequential patterns of SNS and PSNS activity immediately after admission to the emergency department (ED). Also measured noninvasive hemodynamic patterns, including: cardiac index (CI) by bioimpedance, as well as HR, and mean 'arterial pressure (MAP) to evaluate cardiac function, pulse oximetry to reflect changes in respiratory function, and transcutaneous oxygen (PtcO2) to reflect tissue perfusion/ oxygenation.

RESULTS: In all patients autonomic balance (the ratio of SNS to PSNS activity) was markedly abnormal. These patients also had low MAP, CI, and PtcO2/FiO2 values associated with increased HRV that reflect increased autonomic activity. Patients with improved or restored ANS early in their ED stay, all survived; while the latter admission to ED had mixed results. ANS balance was not well-correlated with HR, BP, and CI.

CONCLUSION: In nonsurvivors, severe sepsis and septic shock were associated with pronounced ANS imbalance. Survivors had relatively normal ANS balance. Patients that first presented poor ANS balance had balance improved due to therapy, also survived.

CLINICAL IMPLICATIONS: Shows a correlation between the condition of severe sepsis and septic shock patients and their autonomic balance.

DISCLOSURE: Joseph Colombo, Shareholder Joe Colombo, PhD is a share holder and part owner of Ansar, Inc.; Employee Joe Colombo is the Executive VP and Medical Director of Ansar, Inc.

William C. Shoemaker MD Adam Colombo DO Joseph Colombo PhD * Department of Science and Technology, Bucks County Community College, Newtown, PA

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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