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Shock

In medicine, shock (hypoperfusion) is a life-threatening medical emergency characterized by inability of the circulatory system to supply enough oxygen to meet tissue requirements. Hypotension is usually, though not always, present. Without prompt medical treatment, shock usually causes death. more...

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Types of shock

  • Hypovolemic shock. The single most common cause of shock is blood volume loss, resulting from a serious wound or a severe burn leading to hypovolemic shock. This may also be referred to as haemmorhagic shock.
  • Cardiogenic shock is caused by the failure of the heart to pump effectively. This can be due to damage to the heart muscle, most often from a large myocardial infarction. Other causes of cardiogenic shock include arrhythmias, or cardiac valve problems.
  • Distributive shock. As in hypovolemic shock there is an insufficient volume of blood. This form of relative hypovolaemia is the result of dilation of bloodvessels. Examples of this form of shock are:
    • Septic shock is caused by overwhelming infection leading to vasodilation. It is treated by antibiotics, fluid replacement, and vasoconstrictors.
    • Acute adrenal insufficiency is not infrequently the result of discontinuing corticosteroid treatment without tapering the dosage.
    • Less commonly severe anaphylactic reactions may cause anaphylactic shock as allergens trigger widespread vasodilation and movement of fluid out of the blood into the tissues.
    • The rarest cause of shock is acute spinal cord injury leading to neurogenic shock. Neurogenic shock is caused by the sudden loss of the sympathetic nervous system signals to the smooth muscle in vessel walls. Without this constant stimulation the vessels relax resulting in a sudden decrease in peripheral vascular resistance and decreased blood pressure.
  • Obstructive shock. Hereby the flow of blood is obstructed. Several conditions result in this form of shock.
    • Cardiac tamponade, in which blood in the pericardium prevents inflow of blood into the heart (venous return). Or constrictive pericarditis which has the same effect.
    • Tension pneumothorax. Through increased intrathoracic pressure bloodflow to the heart is prevented (venous return).
    • Massive pulmonary embolism is the result of a thromboembolic incident in bloodvessels of the lungs and hinders the return of blood to the heart.

Symptoms and signs

The external signs and symptoms of shock are:

  • feeling of thickness, weakness, thirst;
  • pallor, especially visible at the inner side of the lips when the casualty has a dark skin;
  • rapid pulse (tachycardia, more than 120 beats per minute), the radial pulse is difficult to feel;
  • when pressing a finger nail, it takes more than two seconds for the color to come back;
  • confusion or anxiety;

Other signs can be evaluated:

  • decreased urine production
  • low blood pressure.

Patients with hypovolaemic or cardiogenic shock will have cold and clammy hands and feet. Septic, anaphylactic and neurogenic shock may present with warm extremities.

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The safety of dopamine versus norepinephrine as vasopressor therapy in septic shock
From CHEST, 10/1/05 by Jaime J. Simon Grahe

PURPOSE: We evaluated a strategy of dopamine (DA) vs norepinephrine (NE) as the primary vasopressor support in patients with septic shock. Concern for potential adverse events or a significant improvement in outcome prompted an interim safety analysis after approximately 50% of the target subjects were enrolled.

METHODS: MICU patients with septic shock were prospectively randomized to receive either DA or NE as the first-line vasopressor. All patients were treated with early-goal directed medical therapy including luid resuscitation, antibiotics, tight glycemic control and management of adrenal insufficiency, as appropriate. A protocol governed the titration of vasopressors to achieve a mean arterial pressure (MAP) of > 60mmHg or systolic blood pressure (SBP) > 90mmHg. After the maximum dose of either DA or NE was reached, patients received vasopressin at a fixed dose of 0.04 units/minute, followed by titration of phenylephrine to maintain the bloodpressure goal. An interim analysis was performed to evaluate safety and efficacy of each vasopressor.

RESULTS: Sixty-six patients, 35 DA and 31 NE, have been enrolled in the study. APACHE II scores, gender, and age were all similar at baseline between the two groups. There was no significant difference in mortality comparing the two groups (DA 40%, NE 41.8%). Cardiac dysrhythmias occurred in 31.4% of the DA group compared to 3.2% for NE (p=0.003). All cardiac dysrhythmias required an intervention.

CONCLUSION: There was a significant increase in cardiac dysrhythmias associated with DA treatment in comparison to NE treatment of septic shock.

CLINICAL IMPLICATIONS: While there was no significant difference in mortality between the two vasopressor regimens, the significant increase in dysrhythmias associated with DA administration raises significant safety concerns. Further testing is needed to confirm the safety of dopamine and ensure that it is not detrimental to septic shock patients.

DISCLOSURE: Jaime Simon Grahe, None.

Jaime J. Simon Grahe DO * Gourang P. Patel PharmD Ellen Elpern RN Robert A. Balk MD Rush University Medical Center, Chicago, IL

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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