Theophylline chemical structure
Find information on thousands of medical conditions and prescription drugs.

Uniphyl

Theophylline is a methylxanthine drug and is used in therapy for respiratory diseases, under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to caffeine. It is naturally found in black tea and green tea. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
Ubidecarenone
Ultram
Unasyn
Unipen
Uniphyl
Unisom
Urethane
Urofollitropin
Urokinase
Uroxatral
Ursodeoxycholic acid
V
W
X
Y
Z

The main actions of theophylline are:

  • relaxation of bronchial smooth muscle
  • positive inotropic (increases heart muscle contractility and efficiency)
  • positive chronotropic (increases heart rate)
  • lowers blood pressure
  • increases renal blood flow
  • some anti-inflammatory effect

The use of theophylline is complicated by the fact that it interacts with various drugs, chiefly cimetidine and phenytoin, and that it has a narrow therapeutic index, so its use must be monitored to avoid toxicity. It can also cause nausea, diarrhœa, increase in heart rate, arrhythmias and CNS excitation. Its toxicity is increased by erythromycin, cimetidine and fluoroquinolones.

The main therapeutic uses of theophylline are:

  • chronic obstructive diseases of the airways
    • chronic obstructive pulmonary disease COPD
    • bronchial asthma

Proposed mechanism of action include a non-specific inhibition of the enzyme phosphodiesterase, producing an increase in intracellular cyclic AMP, however this is not known with certainty.

Read more at Wikipedia.org


[List your site here Free!]



Sleep quality and nocturnal respiratory function with once-daily theophylline and inhaled salbutamol in patients with COPD - Uniphyl - chronic obstructive
We compared the effects of evening administration of sustained-release theophylline (Uniphyl) and qid inhaled [[beta].sub.2]-agonist (salbutamol, two 100-[mu]g puffs) on sleep quality and nocturnal o
A time to heal: chronotherapy tunes in to body's rhythms
Each person's body has its own rhythms that are formed by genetics and influenced by the environment. Determining the rhythms and how the body is affected ...
Significant drug-nutrient interactions - includes patient information handout - Clinical Pharmacology
Many nutrients substantially interfere with pharmacotherapeutic goals. The presence of certain nutrients in the gastrointestinal tract affects the bioavailability ...
Conversion of COPD patients from multiple to single dose theophylline: serum levels and symptom comparison - chronic obstructive pulmonary disease
The objective of the present study was to determine if patients with COPD who were taking Theo-Dur bid or tid (total dose 400 to 900 mg per day) could ...
Is theophylline obsolete? - Editorial
Be not the first by whom the new are tried, nor yet the last to lay the old aside. Alexander Pope, 1688-1744. For almost 50 years, methylxanthines ...

Home Contact Resources Exchange Links ebay