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Whipple disease

Whipple's disease is a rare disease caused by the bacteria Tropheryma whipplei. more...

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Medicines

It was first described by George Hoyt Whipple in 1907.

Symptoms

  • arthritis
  • malabsorption
  • intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine)
  • lymphadenopathy
  • abdominal pain
  • diarrhea
  • fever

Diagnosis

Diagnosis is made by intestinal biopsy, which shows as PAS-positive macrophage inclusions.

At times, small bowel X-rays may show some thickened folds.

Treatment

Treatment is with penicillin, ampicillin, tetracycline or co-trimoxazole for 4-6 months.

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Whipple Disease: A Case Report and Review of the Literature
Whipple disease is a chronic, relapsing, and multisystem disease. It presents a diagnostic challenge for both clinicians and pathologists. Recent advances ...
From Archives of Pathology & Laboratory Medicine, 7/1/05 by Muir-Padilla, Jeannie
Vitamin supplements; music; blood loss in hip surgery; Whipple's disease transmission - Evidence For Practice
Supplements' effects on patient infections and well-being Annals of Internal Medicine March 4, 2003 Dietary supplements are used extensively throughout ...
From AORN Journal, 8/1/03 by George Allen
Whipple's disease. Report of five cases with different clinical features
SUMMARY Whipple's disease (WD) is a rare systemic disease of infectious etiology which involves the small intestine but can virtually affect any organ.
From Revista do Instituto de Medicina Tropical de Sao Paulo, 1/1/01 by de Abreu Ferrari, Maria de Laurdes
Autoimmune Pancreatitis: More Than Just a Pancreatic Disease? A Contemporary Review of Its Pathology
Context.-Autoimmune pancreatitis (AIP) is a chronic inflammatory condition of the pancreas constituting one quarter of Whipple resections performed for ...
From Archives of Pathology & Laboratory Medicine, 9/1/05 by Deshpande, Vikram
Pancreatic cancer: the whipple: for patients undergoing a pancreaticoduodenectomy—a complex, high-risk operation for pancreatic cancer also known
In 1997, after an illustrious 45-year career in the ministry, Arthur DeKruyter of Oak Brook, Illinois, looked forward to a peaceful yet active retirement ...
From Saturday Evening Post, 5/1/02 by Patrick Perry
Pernicious anemia
Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B12. True pernicious ...
From Gale Encyclopedia of Medicine, 4/6/01 by Rosalyn S. Carson-DeWitt
Malabsorption syndrome
Malabsorption syndrome is an alteration in the ability of the intestine to absorb nutrients adequately into the bloodstream.
From Gale Encyclopedia of Medicine, 4/6/01 by Kathleen Dredge Wright
Small intestine biopsy
A biopsy is a diagnostic procedure in which tissue or cells are removed from a part of the body and specially prepared for examination under a microscope.
From Gale Encyclopedia of Medicine, 4/6/01 by Janis O. Flores

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