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Estrogel

Estradiol (17-beta estradiol) is a sex hormone. Labelled the "female" hormone but also present in males it represents the major estrogen in humans. Critical for sexual functioning, estradiol also supports bone growth. more...

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Synthesis

Estradiol, like other sex steroids, is derived from cholesterol. After side chain cleavage and either utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary. Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol.

Conversion of testosterone to estradiol:

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Overview: a woman's guide to hormone therapy
From National Women's Health Report, 4/1/04

Hormone therapy (HT) is used to relieve one or more menopausal symptoms caused by declining estrogen levels. These symptoms may include hot flashes, night sweats and vaginal and urinary tract changes. HT can be either estrogen alone or include a progestogen (either progestin or progesterone). Progestogen is added to estrogen therapy to decrease the risk of uterine cancer associated with estrogen-alone therapy for women who have not had a hysterectomy. If you have had a hysterectomy, estrogen-only therapy may be prescribed. Ask your health care professional for details about potential side effects and risks associated with any hormone therapy products you may consider using.

COPYRIGHT 2004 National Women's Health Resource Center
COPYRIGHT 2004 Gale Group

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