When normal cells are damaged beyond repair, they are eliminated by apoptosis.  Cancer cells avoid apoptosis and continue to multiply in an unregulated manner.Cancers are caused by a series of mutations.  Each mutation alters the behavior of the cell somewhat.Tissue can be organized in a continuous spectrum from normal to cancer.The incidence of lung cancer is highly correlated with smoking. Source:NIH.
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Cancer

Cancer is a class of diseases characterized by uncontrolled division of cells and the ability of these cells to invade other tissues, either by direct growth into adjacent tissue (invasion) or by implantation into distant sites (metastasis). This unregulated growth is caused by damage to DNA, resulting in mutations to genes that control cell division. Several mutations may be required to transform a normal cell into a malignant cell. These mutations are often caused by chemicals or physical agents called carcinogens. Some mutations occur spontaneously, or they can be inherited (germ line mutations.) more...

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Cancer can cause many different symptoms, depending on the site and character of the malignancy and whether there is metastasis. Cancer may be painless. A definitive diagnosis usually requires the histologic examination of tissue by a pathologist. This tissue is obtained by biopsy or surgery. Once diagnosed, cancer is usually treated with surgery, chemotherapy, or radiation.

If untreated, cancers may eventually cause death. Cancer is mainly a disease of later years, and is one of the leading causes of death in developed countries. Most cancers can be treated and many cured, especially if treatment begins early. Many forms of cancer are associated with exposure to environmental factors, such as tobacco smoking, alcohol, and certain viruses. Some of these can be avoidable, and public health and vaccination programmes are important on a global scale.

History

Hippocrates described several kinds of cancers. He called benign tumours oncos, Greek for swelling, and malignant tumours carcinos, Greek for crab or crayfish. This strange choice of name probably comes from the appearance of the cut surface of a solid malignant tumour, with a roundish hard center surrounded by pointy projections, vaguely resembling the silhouette of a crab. He later added the suffix -oma, Greek for swelling, giving the name carcinoma. Today, carcinoma is the medical term for a malignant tumour derived from epithelial cells. It is Celsus who translated carcinos into the latin cancer, also meaning crab. Galen used "oncos" to describe all tumours, the root for the modern word oncology.

Classification and nomenclature

Cancers are classified by the type of cell that resembles the tumor and, therefore, the tissue presumed to be the origin of the tumor. The following general categories are usually accepted:

  • Carcinoma: malignant tumors derived from epithelial cells. This group represent the most common cancers, including the common forms of breast, prostate, lung and colon cancer.
  • Lymphoma and Leukemia: malignant tumors derived from blood and bone marrow cells
  • Sarcoma: malignant tumors derived from connective tissue, or mesenchymal cells
  • Mesothelioma: tumors derived from the mesothelial cells lining the peritoneum and the pleura.
  • Glioma: tumors derived from brain cells
  • germ cell tumours: tumors derived from germ cells, normally found in the testicle and ovary
  • Choriocarcinoma: malignant tumors derived from the placenta

Malignant tumors are usually named using the Latin or Greek root of the organ as a prefix and the above category name as the suffix. For instance, a malignant tumor of liver cells is called hepatocarcinoma; a malignant tumor of the fat cells is called liposarcoma. For common cancers, the English organ name is used. For instance, the most common type of breast cancer is called ductal carcinoma of the breast or mammary ductal carcinoma. Here, the adjective ductal refers to the appearance of the cancer under the microscope, resembling normal breast ducts.

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Outsmart breast cancer: from exercise to leafy greens, here's an update on ways to decrease your risk
From Essence, 10/1/05 by Ziba Kashef

Let's get the bad news out of the way: Although Black women don't get breast cancer as often as our White counterparts, we have the highest death rate from it of all racial and ethnic groups in this country. Now for the good news: By making certain lifestyle adjustments, staying up to date on screenings, and taking immolate action if you feel a lump in your breast, you can improve your odds. This is true even if your mother or sister has had breast cancer, or test results show that you have a genetic predisposition.

Take the following new and steps--some tried-and-true, others new and improved--to help protect your breasts:

eat well

No doubt you've heard that eating plenty of fresh fruits and vegetables is essential for overall wellness. According to Christine Homer, a surgeon and author of Waking the Warrior Goddess: Dr, Christine Horner's Program to Protect Against and Fight Breast Cancer (Basic Health), a plant-based diet may also decrease your breast-cancer risk. Fresh fruits and vegetables contain phytochemicals--Horner calls them natural medicines--that perform specific anticancer functions. For example, broccoli, collard greens and other cruciferous veggies are a source of indole-3-carbinol, a phytochemical that inhibits breast-cancer growth.

Another promising anticancer food is actually a spice. Turmeric, a potent antioxidant found in curry, helps prevent cell damage that may lead to cancer. The spice even has its own study at the University of Texas MD Anderson Cancer Center. where researchers are testing it as a chemical-free complement to other cancer-preventing drugs.

An easy way to get turmeric into your diet is to add about one third of a teaspoon to food at the end of cooking, or take a 1,000 milligram daily supplement (with your doctor's blessing, of course). For more information: Check out Homer's Waking the Warrior Goddess and The Strang Cancer Prevention Center Cookbook by Laura Pensiero et al (McGraw-Hill).

get moving

Regular exercise--even if it's just walking--may lessen your breast-cancer risk, according to a report published last spring in the Journal of the American Medical Association. Of nearly 3,000 women studied, those who performed moderate exercise such as walking three to five hours per week cut their risk of breast cancer by half.

According to Homer, exercise works by boosting immune function and decreasing the amount of "bad" estrogen the body produces. Bad estrogen causes breast cells to grow and divide at a more rapid speed, she explains. "The faster they divide, the greater the chance that a cancer mutation will occur."

If you're not doing it already, start walking for 30 minutes three or four times a week. Then work your way up to heart-pumping aerobic exercise. For more information: Read Breast Fitness: An Optimal Exercise and Health Plan for Reducing Your Risk of Breast Cancer by Anne McTiernan, Ph.D., et al (St. Martin's Press).

Watch your weight

Besides weighing down your body and spirit, excess pounds, particularly after menopause, ratchet up breast-cancer risk. Twenty to 30 percent of all postmenopausal breast cancers are thought to be due to obesity," Horner notes.

Although there have been uncertainties about the link between body size and breast cancer, "it's be Jeved that when there's excess fat in the body, it generates estrogen," says Harold P. Freeman, M.D., medical director at the Ralph Lauren Center for Cancer Care and Prevention in New York City.

If you're not sure how much weight you should be carrying, see your physician. In addition to determining your body mass index (BMI)--a measure based on your height and weight--ask your doctor or personal trainer to calculate your body-fat percentage. In women, body fat should not exceed 28 percent, Horner says. If it does, you'll be at high risk for health problems and should reduce body fat.

For more information: Visit the Centers for Disease Control and Prevention Web site (cdc.gov) and search for "body mass index" to calculate your BMI.

Hold the alcohol

Red wine has been touted as a cancer fighter because it contains antioxidants. But when it comes to staving off breast cancer, the risks of drinking red wine and all other alcoholic beverages may outweigh the benefits. According to research that links alcohol to breast cancer, just one drink a day--whether it s beer, a mixed cocktail or wine--can raise your risk by 20 percent.

Blame it on the hormones. Alcohol will increase the amount of estrogen the body produces, Horner explains. "It also increases a hormone called prolactin, which speeds up cell division in the breast." The National Cancer Institute recommends consuming no more than one drink per day.

For more information: Get alcohol facts and resources at ncadd.org, the Web site of the National Council on Alcoholism and Drug Dependence.

stop smoking!

Cigarette smoke is a threat to breast health. And the earlier you pick up the habit, the greater the damage. "If a girl starts smoking in her teenage years, her breast-cancer risk is 50 percent higher for the rest of her life." Homer says.

More surprising, recent research, including a study published this year in the International Journal of Cancer, has indicated that secondhand smoke contributes to breast cancer, even in pre-menopausal women. A combination of higher estrogen levels in younger women and the carcinogens may explain why. So avoid secondhand smoke. And if you smoke, quit right now.

For more information: The National Cancer Institute offers a Web site, smokefree.gov, with a guide to quitting, as well as a toll-free number for local support: (800) QUIT-NOW.

San Francisco freelance writer Ziba Kashef is the author of Like a Natural Woman: The Black Woman's Guide to Alternative Healing and Disease Prevention.

Nothing to Fear

Many of us feel nervous about getting a mammogram, especially if it's our first or if the last one was painful. These tips will reduce your anxiety--and any discomfort

In light of Black women's high breast-cancer mortality rates, we need to be vigilant about checking our breasts. Self-rams (see below) should start at age 20 as should clinical exams at the doctor's office.

Have your first mammogram (called a baseline because this X-ray records what is normal for your breasts) between the ages of 35 and 40. If you're at high risk for breast cancer, your doctor may recommend starting at 30.

Begin annual screening mammograms by age 40. (Some specialists advise women under 45, who tend to have dense breast tissue, to have ultrasounds as well.) Because mammograms use compression to detect lumps, they're uncomfortable. To minimize the discomfort and cope with fear:

Schedule your mammogram for the days following your period. Breasts are less engorged and tender, says Worta McCaskill-Stevens, an oncologist at the National Cancer Institute.

Rest assured that the mammogram itself will not give you breast cancer. "With advances in medical technology, the amount of radiation received in mammoFaphy is very minimal," says the Ralph Laumn cancer center's Harold Freeman. "The possible benefit of early diagnosis far outweighs the risk."

To relax before and after the test, by deep Breathing. Place one hand on your chest and another on your stomach. Take a breath in, counting to three, and let your stomach swell. Your chest should not move. Breathe outon a count of three. Repeat.

The correct breast self-exam

A step-by-step guide to this powerful early-detection tool

Despite headlines in the post that questioned their efficacy, breast self-exams, along with clinical exams and mammograms (see above), remain the gold standard of early detection. To catch potential signs of cancer, it's important to know how your breast tissue normally feels.

Guidelines for examining your breasts at home vary, but here are general steps:

1. Stand undressed in front of a mirror with your hands firmly on your hips. Look carefully for any changes--dimpiing of skin, discoloration, swelling or bulging, redness or an inverted nipple (pushed inward).

2. Raise both arms above your head and look again. Gently squeeze your nipples to see if there is any discharge.

3. Now lie down on your back, placing your left arm behind your head. Use your right hand to check the left breast. Start at the center edge of your left collarbone and work down. Press your finger pads deep into your breast tissue, moving either from side to side or straight down, in rows as if you were mowing a lawn. Make sure you cover the entire breast area, including the area under your breast and your armpit. Squeeze the nipple again and note if there is any discharge, pain or itching.

4. Repeat on the right breast. If you're unsure about your technique, ask your OB-GYN for a demonstration during your next exam.

SOURCES: The Breast Cancer Book (Yale University Press) by Ruth H. Grobstein, M.D., Ph.D.; breastcancer.org; cancer.org.

COPYRIGHT 2005 Essence Communications, Inc.
COPYRIGHT 2005 Gale Group

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