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Castleman's disease

Castleman's disease is a rare disease of the lymphatic system. It involves hypeproliferation of certain B cells that often produce cytokines. There are several variants of this disease. One called multicentric Castleman's disease (MCD) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus that is also the cause of Kaposi's sarcoma and primary effusion lymphoma. MCD most commonly develops in immunosuppressed patients such as those with AIDS. The most striking clinical features of MCD are high fevers, anemia, and low white blood cell counts, which appear to be due to the overproduction of interleukin 6. more...

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There is no standard therapy for Castleman's disease; MCD carries a poor prognosis of about 2 years.

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A Transitional Variant of Castleman's Disease Presenting as a Chylous Pleural Effusion - )
Castleman's disease is an uncommon clinicopathologic entity that results in unregulated growth of lymphoid tissue. It may present as benign involvement ...
From CHEST, 1/1/99 by Terri Ten Hoor
Isolated leptomeningeal Castleman's disease with viral particles in the follicular dendritic cells
To our knowledge, five cases of Castleman's disease involving only the central nervous system have been reported previously. We report a sixth case, ...
From Archives of Pathology & Laboratory Medicine, 11/1/98 by Gulati, Priya
Giant lymph node hyperplasia presenting with chylous pleural effusions - Castleman's disease
A case of giant lymph node hyperplasia (Castleman's disease) with an original presentation of a chylous pleural effusion occurred in a female adolescent.
From CHEST, 10/1/97 by Mark E. Blankenship
Castleman's disease
Castleman's disease, also known as giant lymph node hyperplasia, lymph node hamartoma and angiofollicular mediastinal lymph node hyperplasia, is characterized ...
From American Family Physician, 9/1/89 by Mark A. Goldberg
Castleman's disease of the chest: magnetic resonance imaging features
The value of magnetic resonance imaging (MRI) in the evaluation of vascular abnormalities in the chest is well established. To our knowledge, however, ...
From CHEST, 5/1/94 by
Cardiac tamponade secondary to giant lymph node hyperplasia - Castleman's disease
A unique association of giant lymph node hyperplasia (Castelman's disease) and cardiac tamponade is presented. Although pleural effusions have been ...
From CHEST, 2/1/94 by Alfred C. Nicolosi
Thoracoscopic resection of Castleman disease : case report and review - minimally invasive techniques
Castleman disease is an uncommon entity, most often occurring in patients presenting with localized mediastinal lymph node enlargement. While surgical ...
From CHEST, 1/1/03 by Peter A. Seirafi
A 35-year-old woman with asthma and polycystic lung disease - pulmonary and critical care pearls
(CHEST 2002; 121:256-260) A 35-year-old white woman with a history of asthma since childhood went to her primary-care physician with symptoms of fever, ...
From CHEST, 1/1/02 by Octavian C. Ioachimescu

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