Forty-nine patients with a witnessed out-of-hospital cardiac arrest of presumed cardiac origin, who were in a coma after cardiopulmonary resuscitation (CPR) despite restored spontaneous blood flow, were treated with hypothermia and were randomly assigned to receive, in double-blind fashion, coenzyme Q10 (CoQ10) or placebo. The dose of CoQ10 was 250 mg in liquid form, followed by 150 mg 3 times a day for 5 days, administered through a nasogastric tube. The 3-month survival rate was 68% in the CoQ10 group (17 of 25) and 29% (7 of 24) in the placebo group (p = 0.0413). A good neurological outcome (Glasgow Outcome Scale of 4 or 5) occurred in 9 (36%) of 25 patients in the CoQ10 group and 5 (21%) of 24 in the placebo group (p value not stated).
Comment: Of people who receive CPR after out-of-hospital sudden cardiac arrest, only about 12% are discharged alive from the hospital. More than 90% of survivors are unable to return to their previous lifestyles, mainly because of brain damage. Neuronal death occurs both during ischemia and after reperfusion. Mitochondrial dysfunction and oxidative stress have been implicated in delayed neuronal injury. Therapeutic hypothermia has been shown to improve survival after CPR.
The results of the present study demonstrate that the beneficial effect of hypothermia can be further increased by treatment with CoQ10, which presumably works by enhancing mitochondrial function and reducing oxidative stress. The addition of CoQ10 more than doubled the survival rate and nearly doubled the proportion of people who retained good neurological function.
Future research should investigate the effect of other nutrients that play a key role in mitochondrial function, such as magnesium, niacinamide, and riboflavin. In a previous study, hypomagnesemia was present in 23% of 22 patients after cardiac arrest, and 41% were hypermagnesemic. All patients with abnormal serum magnesium concentrations died, whereas 5 of 8 patients with a normal serum magnesium concentration were successfully resuscitated. That finding suggests that patients who are hypomagnesemic after cardiac arrest might benefit from magnesium therapy.
Damian MS, et al. Coenzyme CoQ10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation 2004;110:3011-3016.
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