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Celiac sprue

Coeliac disease (also called celiac disease, non-tropical sprue, c(o)eliac sprue, gluten enteropathy and gluten intolerance) is a digestive disorder. It is characterised by damage or flattening to all or part of the villi lining the small intestine, causing scar tissue that cannot absorb nutrients. This damage is caused by exposure to gluten and related proteins found in wheat, rye, malt, barley and oats. more...

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Signs and symptoms

Damage to the villi reduces the ability of the intestines to absorb nutrients, and it is believed that the resulting nutritional deficiencies likely cause the wide spectrum of symptoms associated with the disorder. Coeliac disease may lead to digestive problems, such as indigestion, heartburn and irritable bowel syndrome, unexplained weight loss or other signs of nutritional deficiency due to malabsorption, and a wide range of other problems in different bodily systems, including the nervous system, the heart, and the teeth and bones.

Other symptoms can include dermatitis (an itchy rash), diarrhea, excessive tiredness or fatigue, aching in joints and a general feeling of being unwell.

Coeliacs (people with coeliac disease) may also be symptom-free, but they are still doing damage to their small intestines. Regardless of the presence or absence of symptoms, the disorder is associated with an increased risk of osteoporosis and MALT lymphoma, a form of intestinal cancer.

Strict adherence to a gluten-free diet typically resolves all symptoms and conditions caused by coeliac disease. In coeliacs who are not on a gluten-free diet, the disease may present through one or more of the following symptoms. The presence of these symptoms does not mean the individual is coeliac. These symptoms are also associated with other diseases, some of which are life-threatening; therefore, patients with these symptoms should promptly consult a doctor for differential diagnosis.

Dietary deficiencies, which may manifest as symptoms in particular body systems (e.g., digestive or nervous system) or may be noticed on routine blood tests, are common in coeliacs. Up to 50% of coeliac disease patients have malabsorption-related diarrhea (with bulky, pale, offensive-smelling stools which may float in the toilet bowl). This symptom is known as steatorrhea. However, some coeliacs suffer from constipation. Excess flatulence is common, and some coeliacs also experience infrequent, minor rectal bleeding. Unexplained weight loss (or even obesity occasioned by overeating due to cravings for nutrients), indigestion, acid reflux, excessive tiredness (coeliacs have reported falling asleep while driving) and an itchy rash (dermatitis) may also be a sign of the disorder. Delayed puberty (or short stature prior to adolescence) might also be a symptom. Rarely, coeliacs may experience symtoms similar to those of sinus infections and/or the formation of thick, choking plugs or ropes of mucus that require considerable effort to expel. A low-grade, persistent pain may be present, possibly lessened by eating, which may all too easily be taken for the presence of ulcers.

In young children, the most common symptoms are steatorrhoea, weight loss, abdominal distension, and slow growth/failure to thrive, but irritability, vomiting and tiredness are common. It has been suggested that some cases of autism may be caused by coeliac disease.

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Celiac Sprue Disease
From Gale Encyclopedia of Childhood and Adolescence, 4/6/01 by Mary McNulty

A child suffering from celiac sprue disease is unable to digest gluten, the protein present in wheat, oats, and barley. Gluten intolerance surfaces in one out of every 10,000 Caucasian birth; commonly among people of Irish and Scottish descent. Although the exact pattern is unknown, celiac disease tends to run in families. Parents with the intolerance condition themselves should watch their children closely for symptoms, which generally appear within the first two years of life.

Once the intestines become irritated, the absorption of other nutrients is affected. If unchecked, the child can suffer severe growth impairments. In its advanced state, celiac disease can result in clubbed fingers and delayed tooth developments.

The most telling sign is loose, fatty, foul-smelling bowl movements. In addition, the child may be irritable with little or no appetite. His or her abdomen may be distended. Vomiting and dehydration are also common. When the intolerance is present in infants who are eating cereal early, the effects can be life-threatening. These infants need emergency care to replace lost fluids. In most cases, however, by the time celiac disease is diagnosed, the child will have a history of chronic diarrhea ; his or her height and weight will likely be less than the average. Because frequent diarrhea can also signal intestinal infections or lactose intolerance, the physician may perform a biopsy (examination of a small piece of tissue) of the small intestine to determine that celiac disease exists.

Once celiac disease has been diagnosed, all gluten foods should be eliminated from the child's diet. Packaged foods, including baby foods, contain various forms of gluten; any of the following ingredients listed on the package indicate that the food should be avoided: wheat or rye flour, bran, farina, wheat germ, semolina, cereal additives. Based on the results of a 1995 study, some physicians believe that celiac sprue patients can include oat in their diets.

Corn, rice, potato, or soy flour can take the place of the offending grains. A varied diet of unprocessed meats, eggs, milk, cheeses, fish, fruits, and vegetables will provide the child with a nutritionally balanced diet. The child's physician may also recommend that the child take vitamin B and D and iron supplements, and folic acid to aid digestion.

Occasionally a child will develop a temporary sugar intolerance, brought on by the unchecked celiac sprue. In that case, eliminate sugar from the child's diet for four to six weeks until the gluten intolerance is under control. Although the gluten intolerance may subside during adolescence , it often reoccurs during adulthood, particularly in the 30s and 40s. Many physicians consider celiac sprue disease as a life-long condition and recommend that the gluten-free diet be followed throughout life.

Gale Encyclopedia of Childhood & Adolescence. Gale Research, 1998.

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