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Colitis


Colitis is a digestive disease characterized by inflammation of the colon. There are several types of colitis, including ulcerative colitis, Crohn's Disease, ischemic colitis, infectious colitis, and atypical colitis. more...

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Signs and symptoms

Signs and symptoms of colitis include pain, tenderness in the abdomen, fever, swelling of the colon tissue, bleeding, erythema (redness) of the surface of the colon, bleeding, and ulcerations of the colon. Tests that show these signs are plain X-rays of the colon, testing the stool for blood and pus, and colonoscopy. Additional tests include stool cultures and blood tests such as a complete blood count, C-reactive protein, erythrocyte sedimentation rate, and a blood chemistry tests.

Types

A well known subtype of colitis is pseudomembranous colitis, resulting from infection by a toxigenic strain of Clostridium difficile. Other parasitic infections can also cause colitis.

Any colitis which has a rapid downhill clinical course is known as fulminant colitis, which is characterized by severe bloody diarrhea, fever, hypovolemia, and anemia. This type is seen in 5-15% ulcerative colitis patients.

Irritable bowel syndrome is separate disease which has been called spastic colitis. This name causes confusion since colitis is not a feature of irritable bowel syndrome.

Autistic enterocolitis is a disputed medical entity but refers to a type of colitis found in patients with autism.

Treatment

Treatment of colitis may include the administration of antibiotics and general anti-inflammatory medications such as Mesalamine or it's derivatives; steroids, or one of a number of other drugs that downregulate inflammation. Surgery is sometimes needed, especially in cases of fulminant colitis.

Read more at Wikipedia.org


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Abnormal function of platelets and role of Angelica sinensis in patients with ulcerative colitis
From Alternative Medicine Review, 6/1/04

Dong WG, Liu SP, Zhu HH, et al. World J Gastroenterol 2004;10:606-609.

AIM: To explore the abnormal function of platelets and the role of Angelica sinensis injection (ASI) in patients with ulcerative colitis (UC). METHODS: In 39 patients with active UC, 25 patients with remissive UC and 30 healthy people, alpha-granule membrane protein (GMP-140) and thromboxane B(2) (TXB(2)) were detected by means of ELISA, 6-keto-PGF(la) was detected by radioimmunoassay, platelet count (PC) and 1 min platelet aggregation rate (1 min PAR) were detected by blood automatic tester and platelet aggregation tester respectively, and yon Willebrand factor related antigen (vWF:Ag) was detected by the means of monoclonal -ELISA. The 64 patients with UC were divided into two therapy groups. After routine treatment and Angelica sinensis injection (ASI) + routine treatment respectively for 3 weeks, all these parameters were also detected. RESULTS: The PC, 1 min PAR and levels of GMP-140, TXB(2), and vWF:Ag in active UC were significantly higher than those in remissive UC and normal controls (P<0.05-0.01).Meanwhile, 1 min PAR and levels of GMP-140, TXB(2), and vWF:Ag in remissive UC were still significantly higher than those in normal controls (P<0.05). Furthermore, 6-keto-PGF(la) level in active and remissive UC was remarkably lower than that in normal control (P<0.05-0.01). These parameters except 6-keto-PGF(la) were significantly improved after the treatment in ASI therapy group (P<0.050.01), whereas they all were little changed in routine therapy group (P>0.05). CONCLUSION: Platelets can be significantly activated in UC, which might be related with vascular endothelium injury and imbalance between TXB(2) and 6-keto-PGF(la) in blood. ASI can significantly inhibit platelet activation, relieve vascular endothelial cell injury, and improve microcirculation in UC.

COPYRIGHT 2004 Thorne Research Inc.
COPYRIGHT 2004 Gale Group

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