Hartnup disease
Hartnup disease, or Hartnup's disease, or Hartnup disorder, is a genetic metabolic disorder in the synthesis of the amino acid tryptophan that leads to the insufficent production of nicotinamide.
Symptoms
Nicotinamide is necessary for neutral amino acid transporter production in the proximal renal tubules found in the kidney, and intestinal mucosal cells found in the small intestine. Therefore, a symptom stemming from this disorder results in increased amounts of amino acids in the urine.
Pellagra is also caused by low nicotinamide; this disorder results in dermatitis, diarrhea and dementia.
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