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Hyperkalemic periodic paralysis

Hyperkalemic periodic paralysis (HYPP), also known as Impressive Syndrome, is an inherited autosomal dominant disorder which affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood of horses. This inherited disease is characterized by uncontrollable muscle twitching and substantial muscle weakness or paralysis among affected horses. HYPP is a dominant disorder; therefore heterozygotes bred to genotypically normal horses will still likely produce clinically affected offspring 50% of the time. more...

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The disease is contained to the bloodline of the famous Appendix American Quarter Horse stallion Impressive, who has over 55,000 living descendants as of 2003. Although the disease is primarily limited to the American Quarter Horse breed and closely related breeds such as American Paint Horses and Appaloosas at this time, cross-breeding has begun to extend it to grade horses and ponies. The spread of the disease is perpetuated by the favorable judgings given to diseased horses in showing, due in part to involuntary muscle twitching which helps to build large, bulky muscles that judges favor.

In 1994, researchers at the University of Pittsburgh, with a grant from various horse organizations, isolated the gene responsible for the problem and developed a blood test for it. Using this test, horses may be identified as:

  • H/H, meaning they have the gene and it is homozygous. These horses always pass on the disease.
  • N/H, meaning they have the gene and it is heterozygous. These horses are affected to a lesser degree, and pass on the disease 50% of the time.
  • N/N, meaning they do not have the disease and cannot pass it on, even if they are a descendant of Impressive.

Recently, horse organizations have begun instituting rules to attempt to eliminate this widespread disease. The American Quarter Horse Association (AQHA) now mandates testing for the disease and will no longer register homozygous (H/H) foals as of 2007, with discussion of heterozygous (N/H) foals pending. The Appaloosa Association will no longer accept homozygous foals as of 2008. It is believed that both primary palomino registries will exclude any HYPP-carrying foal as of 2007. The main organization affected by HYPP that has not yet taken action is the American Paint Horse Association (APHA), although many other smaller organizations are also affected.

Although much rarer, hyperkalemic periodic paralysis has also been observed in humans. The most common underlying cause is one of several possible point mutations in the genes synthesising calcium or sodium ion channels in skeletal muscle; this mutation can either be inherited in an autosomally dominant or recessive manner.

Read more at Wikipedia.org


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Matched pick in Lotto not rigged
From Deseret News (Salt Lake City), 3/10/05 by Bill Sones

Question: In the German Lotto on June 21, 1995, the numbers 15- 25-27-30-42-48 were drawn out of 49. Bizarrely, it was later discovered that these same six had been drawn on Dec. 20, 1986, something that hadn't happened before in the 3,016 drawings of the lotto. With nearly 14 million combos possible, how incredible was this really? Was someone rigging the picks?

Answer: Pardon the daunting math, but to figure the likelihood of getting a match in 3,016 drawings, first you need to figure the likelihood of getting NO matches, says Henk Tijms in "Understanding Probability."

Start by multiplying 13,983,816 x (13,983,816 - 1) x (13,983,816 - 2) . . . x (13,983,816 - 3,015). There are 3,016 factors here. Then divide by 13,983,816 to the 3016 power!

Once your overworked computer cools off, you'll see an answer of 0.7224. But that's the likelihood of no matches; instead subtract 1 - 0.7224 to find the likelihood of at least one match, which equals 0.2776. This means there was a better than 1 in 4 chance that this would happen in 3,016 drawings!

What fools people is that the chance of matching a PARTICULAR six- number-sequence is vanishingly small, but not the chance of matching SOME six-number-sequence along the way.

Says Tijms: This is basically another version of the classic birthday paradox, where all it takes is 23 people in a room for there to be a 50-50 chance of at least two of them having the same birthday. "In the lottery situation, it's analogous to there being 3,016 people in the room and 13,983,816 possible birthdays."

So no rigging necessary but just someone's incredible recordkeeping to track thousands of picks and spot the repeat.

Question: Is there such a thing as an "average man" or an "average woman"?

Answer: The term was coined by Belgian scientist Adolphe Quetelet in the 1830s when he realized that measurements of heights and chest circumferences of French and Scottish soldiers followed a "normal distribution," the classic bell-shaped curve, say Jeffrey Bennett and William Briggs in "Using and UnderstandingMathematics."

Fundamentally, any quantity that is the result of MANY factors is likely to follow such a distribution, as with adult heights (resulting from many genetic and environmental factors), chest sizes, shoe sizes, I.Q.s, SAT scores, and on and on. While there is an average man/woman on each of these, there is no average man or woman on all of them.

Question: An exceptionally beautiful quarter horse eats a banana, goes into uncontrollable muscle spasms and paralysis, suffers irregular heartbeat and obstructed airways, then topples over and dies. What was wrong with the horse?

Answer: It had a defective gene -- the same one responsible for its beautiful musculature -- giving it "hyperkalemic periodic paralysis," says Sharon Bertsch McGrayne in "365 Surprising Scientific Facts, Breakthroughs, and Discoveries."

Tens of thousands of quarter horses in the United States have this, affecting their ability to metabolize potassium-rich foods like alfalfa and bananas. Evidence suggests they all inherited the gene from one particular stallion used as a stud in the 1970s and 1980s. Tests can be done to identify the gene, so it could be eliminated in a single generation.

Breeders, however, may not want to get rid of the gene, which many believe add to the beauty of the horses, raised as much for show as for racing. "Alternatively, the disease can be controlled via diet and diuretics."

Send STRANGE questions to brothers Bill and Rich at strangetrue@compuserve.com

Copyright C 2005 Deseret News Publishing Co.
Provided by ProQuest Information and Learning Company. All rights Reserved.

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