In this report, a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital Bowen's disease was treated with imiquimod. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 DNA was no longer detectable. DNA image cytometry revealed DNA aneuploidy (an indicator of prospective malignancy) in pretreatment samples but not in post-treatment samples. Therefore, imiquimod might be a treatment option for Bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated.
Gutzmer R, Kaspari M, Vogelbruch M, Kiehl P, Kapp A, Werfel T, Brodersen JP. Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry. Br J Dermatol 2002 Jul; 147(1): 160-5.
COPYRIGHT 2002 Journal of Drugs in Dermatology
COPYRIGHT 2003 Gale Group
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