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Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, mucocutaneous lymph node disease, infantile polyarteritis and Kawasaki syndrome, is a poorly-understood non-contagious illness that affects the mucous membranes, lymph nodes, blood vessel walls, and the heart. It was first described in 1967 by Dr. Tomisaku Kawasaki. more...

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Incidence, causes, and risk factors

Kawasaki disease occurs mainly in Japan, though its incidence in the United States is increasing. Kawasaki disease is predominantly a disease of young children, with 80% of patients younger than 5 years of age, but no other contributing factors are known.

The causative agent of Kawasaki disease is still unknown. But current etiological theories center on immunological causes for the disease. Much research is being performed to discover a definitive toxin or antigenic substance, possibly a superantigen, that is the specific cause of the disease.

The cardiac involvement and complications are, by far, the most important aspect of the disease. Kawasaki disease can cause vasculitis (inflammation of blood vessels) in the coronary arteries and subsequent coronary artery aneurysms. These aneurysms can lead to myocardial infarction (heart attack) even in young children (rarely). About 20–40% of children with Kawasaki disease will have evidence of vasculitis with cardiac involvement.

Kawasaki disease often begins with a high and persistent fever that is not very responsive to normal doses of acetaminophen or ibuprofen. The fever may persist steadily for up to two weeks. The children develop red eyes, red mucous membranes in the mouth, red cracked lips, a "strawberry tongue" and swollen lymph nodes. Skin rashes may occur early in the disease and peeling of the skin in the genital area, hands, and feet (especially around the nails and on the palms and soles) may occur.


  • High-grade fever (greater than 39 °C or 102 °F; often as high as 40 °C or 104 °F) that is unresponsive to medication and lasts more than three days (persistent fever lasting at least five days is considered a hallmark sign)
  • Extremely bloodshot or red eyes (conjunctivitis without pus or drainage)
  • Bright red, chapped, or cracked lips
  • Red mucous membranes in the mouth
  • Strawberry tongue, white coating on the tongue or prominent red bumps (papillae) on the back of the tongue
  • Red palms of the hands and the soles of the feet
  • Swollen hands and feet
  • Peeling palms and soles (later in the illness); peeling may begin around the nails
  • Rashes similar to erythema multiforme (rash, NOT blister-like, on the trunk)
  • Swollen lymph nodes (frequently only one lymph node is swollen), particularly in the neck area
  • Joint pain (arthralgia) and swelling, frequently symmetrical

Signs and tests

A physical examination will demonstrate many of the symptoms listed above. Procedures such as ECG and echocardiography may reveal signs of myocarditis, pericarditis, arthritis, aseptic meningitis, and coronary vasculitis.


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Pulmonary nodules may resolve spontaneously. (Kawasaki Disease). : An article from: Skin & Allergy News $5.95 Acute respiratory distress syndrome in a child with Kawasaki disease. : An article from: Southern Medical Journal $5.95
Kawasaki Disease $160.00 Cardiac abnormalities may appear late in KD patients.(Cardiovascular Medicine)(Kawasaki disease) : An article from: Family Practice News $5.95
Newly discovered virus linked to childhood lung disorders and Kawasaki disease.(EH Update) : An article from: Journal of Environmental Health $5.95 Kawasaki-like syndrome seen in carbamazepine user. (In 8-Year-Old Girl). : An article from: Skin & Allergy News $5.95
Kawasaki diagnosis often misses cardiac disease. (Guideline Rewrite is Overdue).(Brief Article) : An article from: Pediatric News $5.95 Early ASA has benefit in acute Kawasaki disease. (Low Dose vs. High Dose Questioned).(acetylsalicy lic acid) : An article from: Skin & Allergy News $5.95
Ask Doctor Cory.(your health questions and answers)(Brief Article) : An article from: Children's Digest $5.95 Steroids may help Kawasaki disease treatment: one of top 10 pediatric ID articles.(Children's Health) : An article from: Family Practice News $5.95

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