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Kernicterus

Kernicterus is damage to the brain centers of infants caused by jaundice. Newborn babies are often polycythemic, meaning they have too many red blood cells. When they break down the cells, one of the by-products is bilirubin, which circulates in the blood, and causes jaundice.

In adults and older children, jaundice is harmless in and of itself. But the tissues protecting the brain (the blood-brain barrier) are immature in newborns. The bilirubin penetrates the brain, and literally stains the nerve bodies, causing irreversible damage. Depending on the level of exposure, the effects range from unnoticeable to severe brain damage.

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Bilirubin guideline stresses increased awareness: would prevent kernicterus.(Clinical Rounds) : An article from: Pediatric News $5.95 Unbound bilirubin in a term newborn with kernicterus. (Experience And Reason--Briefly Recorded). : An article from: Pediatrics $5.95
AAP Is Revising Hyperbilirubinemia Guidelines. : An article from: Pediatric News $5.95 Prevention of kernicterus: a lesson from the past.(Letters to the Editor)(Letter to the Editor) : An article from: Pediatrics $5.95
Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm ... Abstract) : An article from: Pediatrics $5.95 Vigintiphobia revisited. : An article from: Pediatrics $5.95
LETTERS.(The Real Cause of Kernicterus)(Just Walk On Out)(Tedious Committee Meetings)(Letter to the Editor) : An article from: Pediatric News $5.95 Investigational drug looks good for hyperbilirubinemia: FDA panel debate.(Children's Health)(stannsoporfin) : An article from: Family Practice News $5.95
Cry analysis in infants with Rh haemolytic disease (Acta paediatrica Scandinavica)

Kernicterus in Full-Term Infants — United States, 1994-1998
Kernicterus is a preventable life-long neurologic syndrome caused by severe and untreated hyperbilirubinemia during the neonatal period. High levels ...
From Morbidity and Mortality Weekly Report, 6/15/01
Unwelcome return for kernicterus
NEONATAL JAUNDICE Because of shorter hospital stays for newborns, severe jaundice, which can cause hearing loss and brain damage or kernicterus, is going ...
From Nursing, 11/1/03
'Normal' jaundice rates more attention
A PREVENTABLE BRAIN injury in newborn babies is highly unusual, says a leading pediatrics expert. But it is possible to prevent nearly all cases of kernicterus, a rare but devastating brain disorde
From Fit Pregnancy, 8/1/04 by Kim Schworm Acosta
Maternal assessment of neonatal jaundice after hospital discharge - Original Research - Statistical Data Included
KEY POINTS FOR CLINICIANS * Although kernicterus, or bilirubin encephalopathy, is preventable, it is still occurring. * Parents should be provided ...
From Journal of Family Practice, 5/1/02 by Diane J. Madlon-Kay
Neonatal jaundice
Neonatal jaundice (or hyperbilirubinemia) is a higher-than-normal level of bilirubin in the blood. Bilirubin is a by-product of the breakdown of red blood ...
From Gale Encyclopedia of Medicine, 4/6/01 by Altha Roberts Edgren
Erythroblastosis fetalis
Erythroblastosis fetalis refers to two potentially disabling or fatal blood disorders in infants: Rh incompatibility disease and ABO incompatibility disease.
From Gale Encyclopedia of Medicine, 4/6/01 by Julia Barrett
Liver function tests
Liver function tests, or LFTs, include tests for bilirubin, a breakdown product of hemoglobin, and ammonia, a protein byproduct that is normally converted ...
From Gale Encyclopedia of Medicine, 4/6/01 by Janis O. Flores
Diagnosis and management of G6PD deficiency
Glucose-6-phosphate dehydrogenase deficiency, the most common enzyme deficiency worldwide, causes a spectrum of disease including neonatal hyperbilirubinemia, ...
From American Family Physician, 10/1/05 by Jennifer E. Frank

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