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Kernicterus

Kernicterus is damage to the brain centers of infants caused by jaundice. Newborn babies are often polycythemic, meaning they have too many red blood cells. When they break down the cells, one of the by-products is bilirubin, which circulates in the blood, and causes jaundice.

In adults and older children, jaundice is harmless in and of itself. But the tissues protecting the brain (the blood-brain barrier) are immature in newborns. The bilirubin penetrates the brain, and literally stains the nerve bodies, causing irreversible damage. Depending on the level of exposure, the effects range from unnoticeable to severe brain damage.

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Unwelcome return for kernicterus
From Nursing, 11/1/03

NEONATAL JAUNDICE

Because of shorter hospital stays for newborns, severe jaundice, which can cause hearing loss and brain damage or kernicterus, is going unnoticed in some infants. Caused by excess bilirubin in the blood, jaundice may not develop until several days after birth.

About 60% of American newborns have jaundice, although many recover without treatment. But an accumulation of excess bilirubin is toxic to the brain.

Kernicterus was fairly common in the United States before phototherapy was developed to break down excess bilirubin in the bloodstream. By the mid-1980s, kernicterus was virtually eliminated. But today, with apparently healthy newborns being released from the hospital shortly after birth, some cases of severe jaundice aren't recognized and treated in time, with tragic consequences.

Health officials are considering various ways to counter this trend. One proposal is to require a blood test to measure bilirubin levels in all newboms. Advocacy groups are campaigning for routine jaundice checkups 2 days after babies leave the hospital. In addition, a promising drug called Stannsoporfin, which would limit bilirubin production in high-risk infants, is currently under study.

The American Academy of Pediatrics plans to release jaundice guidelines by the end of the year. For more information, visit their Web site at http-// www.aap.org.

Copyright Springhouse Corporation Nov 2003
Provided by ProQuest Information and Learning Company. All rights Reserved

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