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Lipodystrophy

In medicine, lipodystrophy is a condition characterized by abnormal or degenerative conditions of the body's adipose tissue. ("Lipo" is Latin for "fat" and "dystrophy" is Latin for "abnormal or degenerative condition".) more...

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Medicines

Insulin injections

A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For diabetics, using purified insulins may also help.

Antiretroviral drugs

Other lipodystropies manifest as the excess or lack of fat in various regions of the body. These include but are not limited to having sunken cheeks, "humps" on the back or back of the neck. They are often seen as a symptom of AIDS or as side-effects from antiretroviral drugs.

Hereditary forms

Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterised by insulin resistance and are associated with Syndrome X.

Read more at Wikipedia.org


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Leptin to treat lipodystrophy
From Journal of Drugs in Dermatology, 1/1/05

This study is currently recruiting patients.

Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

This study will evaluate the safety and effectiveness of leptin replacement therapy in patients with lipodystrophy (also called lipoatrophy). Patients have a total or partial loss of fat cells. They also lack the hormone leptin, which is produced by fat cells. The leptin deficiency usually causes high blood lipid (fat) levels and insulin resistance that may lead to diabetes. Patients may have hormone imbalances, fertility problems, large appetite, and liver disease due to fat accumulation.

Study ID Numbers: CDR0000385682; NCCTG-N03CB

ClinicalTrials.gov Identifier: NCT00091247

COPYRIGHT 2005 Journal of Drugs in Dermatology
COPYRIGHT 2005 Gale Group

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