Find information on thousands of medical conditions and prescription drugs.

MASA syndrome

MASA syndrome is a rare hereditary neurological disorder. The name is an acronym describing the four major symptoms - Mental retardation, Aphasia, Shuffling gait, and Adducted thumbs.

Home
Diseases
A
B
C
D
E
F
G
H
I
J
K
L
M
Mac Ardle disease
Macroglobulinemia
Macular degeneration
Mad cow disease
Maghazaji syndrome
Mal de debarquement
Malaria
Malignant hyperthermia
Mallory-Weiss syndrome
Malouf syndrome
Mannosidosis
Marburg fever
Marfan syndrome
MASA syndrome
Mast cell disease
Mastigophobia
Mastocytosis
Mastoiditis
MAT deficiency
Maturity onset diabetes...
McArdle disease
McCune-Albright syndrome
Measles
Mediterranean fever
Megaloblastic anemia
MELAS
Meleda Disease
Melioidosis
Melkersson-Rosenthal...
Melophobia
Meniere's disease
Meningioma
Meningitis
Mental retardation
Mercury (element)
Mesothelioma
Metabolic acidosis
Metabolic disorder
Metachondromatosis
Methylmalonic acidemia
Microcephaly
Microphobia
Microphthalmia
Microscopic polyangiitis
Microsporidiosis
Microtia, meatal atresia...
Migraine
Miller-Dieker syndrome
Mitochondrial Diseases
Mitochondrial...
Mitral valve prolapse
Mobius syndrome
MODY syndrome
Moebius syndrome
Molluscum contagiosum
MOMO syndrome
Mondini Dysplasia
Mondor's disease
Monoclonal gammopathy of...
Morquio syndrome
Motor neuron disease
Motorphobia
Moyamoya disease
MPO deficiency
MR
Mucopolysaccharidosis
Mucopolysaccharidosis...
Mullerian agenesis
Multiple chemical...
Multiple endocrine...
Multiple hereditary...
Multiple myeloma
Multiple organ failure
Multiple sclerosis
Multiple system atrophy
Mumps
Muscular dystrophy
Myalgic encephalomyelitis
Myasthenia gravis
Mycetoma
Mycophobia
Mycosis fungoides
Myelitis
Myelodysplasia
Myelodysplastic syndromes
Myelofibrosis
Myeloperoxidase deficiency
Myoadenylate deaminase...
Myocarditis
Myoclonus
Myoglobinuria
Myopathy
Myopia
Myositis
Myositis ossificans
Myxedema
Myxozoa
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

Read more at Wikipedia.org


[List your site here Free!]


Dengue 3 epidemic, Havana, 2001
From Emerging Infectious Diseases, 4/1/04 by Otto Pelaez

In June 2001, dengue transmission was detected in Havana, Cuba; 12,889 cases were reported. Dengue 3, the etiologic agent of the epidemic, caused the dengue hemorrhagic fever only in adults, with 78 cases and 3 deaths. After intensive vector control efforts, no new cases have been detected.

**********

In 1994, after 17 years of absence, Nicaragua, Panama, and Costa Rica reported the reintroduction of dengue 3 virus in the region (1,2). The last isolation of this serotype occurred in 1977-1978 in Puerto Rico and Colombia (1,2). Dengue 3 has been related to dengue fever (DF) and dengue hemorrhagic fever (DHF) epidemics. In 7 years the virus has disseminated first to Central-American countries, and later to Mexico, Caribbean countries, and more recently, to South America (3). This virus is genetically different from the dengue 3 strain previously isolated in the Americas and belongs to the same genotype as the virus that caused DHF epidemics in Sri Lanka and India (subtype III) (4). Currently, it is believed that millions of persons in the American region are at risk of dengue 3 infection.

Previously, larger epidemics in Cuba were associated with dengue 1 in 1977 and with dengue 2 in 1981. Both epidemics affected the entire country, producing more than 500,000 and 300,000 dengue cases, respectively. More than 10,000 cases of DHF causing 158 deaths were reported in 1981. From 1982 to 1996, no dengue transmission was reported. In 1997, a dengue 2 epidemic was reported in the municipality of Santiago de Cuba, located in the eastern part of the country (5). In September 2000, a small outbreak of dengue was detected in Havana City; 138 cases of dengue fever (DF) were confirmed at that time, and both dengue 4 and dengue 3 viruses were isolated; the outbreak ended by December (6,7).

The Study

Havana is the capital city of the Republic of Cuba with 15 municipalities, 2,193,848 inhabitants, and a population density of 3,040/[km.sup.2]. Located in the north of the country, it covers an area of 720.84 [km.sup.2] and has an annual average temperature of 25[degrees]C. La Habana province surrounds Havana City on the east, west, and south. House indexes (percentage of houses with at least one infested container) of 0.05 to 0.91 were reported from 1997 to 2001. In July 2001, house indexes at the municipalities of the city varied from 0.2 to 1.5; however, higher figures were observed at health areas and blocks. These data demonstrate that transmission risk must be assessed in more numerous, smaller geographic areas. The entomologic surveillance and vector control activities involved 4,796 workers; 3,278 family doctors' offices (one family doctor per 120 families and 600 inhabitants) and 81 health areas constitute the primary health care system, and 23 hospitals comprise the second and third levels.

Once the Santiago de Cuba epidemic was detected in January 1997 (5,8,9), an active dengue surveillance system was established throughout the country. Specifically in Havana City, the surveillance was directed at detecting dengue transmission by studying patients with undifferentiated fever and patients with suspected dengue (patients with fever and two or more symptoms of DF such as myalgia, arthralgia, headache, and rash).

A serum sample for dengue immunoglobulin (Ig) M detection was collected 5 days after onset of fever. IgM studies were conducted first at the laboratory of the Centro Provincial de Higiene y Epidemiologia de Ciudad Habana (CPHE-CH) by using the ultramicro-enzyme-linked immunosorbent assay ([micro]M ELISA) for dengue IgM detection (10). Positive samples were confirmed at the national reference center, the Tropical Medicine Institute (IPK) by an IgM capture ELISA (11). A comprehensive study from clinical, epidemiologic, and entomologic perspectives was conducted at those health areas where case-patients were found; a second serum sample was collected 2-3 weeks after illness onset to demonstrate the antibody seroconversion or a fourfold increase in antibody titer (12). The Table shows the total number of serum samples studied from 1997 to 2002.

In June 29, 2001, a confirmed dengue case was reported to the national health authorities. The index case had an onset date of June 16. The index case-patient was a 68-year-old white woman who lived in the "26 de Julio" health area of the Playa municipality; she had no history of travel outside the country. The "26 de Julio" health area was a residential location with a noncontinous water supply (it received water every 2 days). The house index was 2.1. Many persons from dengue-endemic countries lived in the area, and many boarding houses also characterized this area.

Within 2 weeks, 20 additional DF cases were serologically confirmed. A retrospective seroepidemiologic study was conducted in a radius of 1 [km.sup.2] around the index patient to look for any patients with suspected dengue or undifferentiated fever; 312 febrile patients, and 14 suspected DF patients were found; however, DF was confirmed by serologic studies in 4 of them. All 4 case-patients had dengue IgM and high titers of IgG dengue antibodies. Epidemiologic studies of these patients showed that the first case occurred in late May or early June. The primary case-patient was a 53-year-old white man from the same health area as the index patient.

Once transmission was confirmed, a proactive dengue surveillance program was established, based on information from family doctors. Virologic and molecular surveillance demonstrated that dengue 3 was the etiologic agent of the epidemic. Ninety-one dengue 3 isolates were obtained from samples collected at various times during the epidemic.

Considering the active surveillance and that specimens from all identified clinical case-patients were studied by serologic or virologic methods, the figure of confirmed cases is very close to the total number of dengue clinical cases of the epidemic. All confirmed case-patients were notified. Figure 1 shows the histogram of the epidemic, and Figure 2 shows the municipality distribution and the date of confirmed transmission in the city. By week 30 (July) new cases were detected in the Arroyo Naranjo Municipality, and by the end of October (week 42), almost all municipalities had reported dengue transmission.

[FIGURES 1-2 OMITTED]

The wide clinical spectrum of dengue was established in the Pan American Health Organization (PAHO)/World Health Organization (WHO) guidelines (13). Because of the detection of dengue transmission in the city, the existence of the primary health system, and the strong dengue surveillance system that included laboratories with appropriate technology for serologic diagnosis, we decided to extend the clinical, epidemiologic, and laboratory surveillance to the study of almost all undifferentiated fever cases and those patients with a compatible classic dengue picture. A house-by-house survey for febrile cases and dengue suspected cases was performed in Havana City by the family doctors. As a result, 72,162 cases (41,830 undifferentiated fever and 30,332 dengue suspected cases) were epidemiologically, clinically, and serologically studied. Dengue infection was confirmed in 12,889 (17.86%) of the total cases. Of patients with confirmed cases, 1,660 (12.9%) were children and 11,229 were adults (87.1%); 52.4% were female and 47.6% were male. DHF was diagnosed in 78 patients, all adults (16-64 years of age). The main signs and symptoms detected in patients with confirmed dengue cases at the time of hospital admission were fever, 100%; headache, 89%; retrorbital pain, 59.2%; arthralgia, 59.4%; myalgia, 35.2%; and rash, 28.1%. Other symptoms such as cough, diarrhea, nausea, and vomiting were observed in 21.2% of case-patients.

The peak of the epidemic occurred in October and the highest number of cases occurred on October 20 (241 confirmed cases); 1,150 cases were confirmed by week 42 (October 14-20).

The onset of symptoms of the last two case-patients occurred by February 22, 2002. The epidemic was considered controlled 36 days later with confirmation that no possibility of transmission existed. Case fatality rate was 3.8% among patients with DHF/dengue shock syndrome (DSS). Mortality rate was 0.13/100,000 inhabitants and morbidity rate was 59.2/ 10,000 inhabitants.

Conclusions

After the first cases were detected, all patients with suspected dengue and those who were severely ill, or those classified as having DHF/DSS were hospitalized, all adults at the IPK hospital and all children at the Aballi and Cerro Pediatric Hospitals. In total, 4,184 patients were hospitalized, 3,197 adults and 987 children. By the end of the epidemic in January 2002, a broad hospitalization policy was established in areas free of vector, Aedes aegpyti mosquitoes, (all febrile and dengue suspected case-patients were hospitalized or treated at home with daily visits by the family doctor). (13). Anatomopathologic and histopathologic studies were conducted in all fatal cases.

The vector control strategy had two phases: the first started as soon as the transmission was detected and restricted the number of cases and geographic extension of the epidemic (the risk of expansion of the epidemic was high because of the vector indexes in Havana City and other provinces).The second phase, called the Intensive Campaign, started at the beginning of January 2002 and interrupted transmission and, consequently, lowered the risk of dengue endemicity in approximately 70 days. The Campaign was based on the principles of dengue control established by the PAHO Guidelines (13) with the involvement of the whole community (the head of state, governmental and political bodies at all levels, householders, community organizations, etc.). The objectives of the Intensive Campaign were to control the vector and interrupt dengue transmission. Massive environmental management and sanitation efforts, the elimination of breeding sites, and the elimination of adult mosquitoes were also carried out. These activities were accompanied by extensive efforts to mobilize the community, a strong program of quality control, the active media involvement, and the repositioning of tanks and different water containers. From a house index of 0.49 at the beginning of the Intensive Campaign, this figure diminished to 0.01 by March 4. The intensive active surveillance and the hospitalization of all febrile patients and all patients thought to be infected with dengue were crucial in order to reduce the dengue transmission.

At present, after 17 months since the last dengue case, strong surveillance is maintained by the six regional laboratories and the national reference center, and no additional cases have been reported. These data indicate that endemicity was avoided. Efforts are being made to eliminate Ae. aegpyti in a regional situation in which the disease has caused unprecedented numbers of cases of DF and DHF (1,015,420 dengue cases and 14374 dengue hemorrhagic fever, with 225 deaths have been reported to PAHO) (data provided by Jorge Arias, WHO American regional office). As has been stated in the PAHO resolution approved by the PanAmerican Health Assembly in September 2002 (14), a concerted action at a regional level is urgently needed.

Acknowledgments

We thank all doctors, nurses, and personnel of the health system and all persons involved in the epidemic detection and control and elimination of the mosquito vector.

References

(1.) Centers for Disease Control and Prevention. Dengue type 3 infection--Nicaragua and Panama, October-November, 1994. Morb Mortal Wkly Rep MMWR 1995;44:21-4

(2.) Guzman MG, Vazquez S, Martinez E, Alvarez M, Rodriguez R, Kouri G, et al. Dengue in Nicaragua, 1994: reintroduction of serotype 3 in the Americas. Pan Am J Public Health 1996;1:193-9

(3.) Rocco IM, Kavakama BB, Santos CL. First isolation of dengue 3 in Brazil from an imported case. Rev Inst Med Trop Sao Paulo 2001;43:55-7

(4.) Gubler DJ. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. In: Gubler DJ, Kuno G, editors. Dengue and Dengue Hemorrhagic Fever. New York: CAB International;1997, p. 1-22.

(5.) Kouri G, Guzman MG. Valdes L, Carbonell I, Rosario D, Vazquez S, et al. Reemergence of dengue in Cuba: a 1997 epidemic in Santiago de Cuba. Emerg Infect Dis 1998;1:89-92.

(6.) Kouri GP, Guzman MG, Bravo JR, Triana C. Dengue hemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ 1989;67:375-80.

(7.) Guzman MG, Kouri G. Dengue: an update. Lancet Inf Dis 2002;2:33-42.

(8.) Valdes L, Guzman MG, Kouri G, Delgado J, Carbonell I, Cabrera MV, et al. La epidemiologia del dengue y el dengue hemorragico en Santiago de Cuba, 1997. Rev Panam Salud Publica 1999;6:16-24.

(9.) Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazquez S, Delgado I, Halstead SB. Epidemiology studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol 2000; 152:793-9.

(10.) Laferte J, Pelegrino JL, Guzman MG, Gonzalez G, Vazquez S, Hermida C. Rapid diagnosis of dengue virus infection using a novel 10 [micro]L IgM antibody capture ultramicroELISA assay (MAC-[micro]M ELISA dengue). Advances in modern biotechnology 1992;1:19.4.

(11.) Vazquez S, Saenz E, Huelva G, Gonzalez A, Kouri G, Guzman MG. Detection de IgM contra el virus del dengue en sangre entera absorbida en papel de filtro. Roy Panam Salud Publica 1998;3:174-8.

(12.) Fernandez R, Vazquez S. Serological diagnosis of dengue by an ELISA inhibition method (ELM). Mere Inst Oswaldo Cruz 1990;85:347-51.

(13.) Pan American Health Organization. Dengue and dengue hemorrhagic fever in the Americas: guidelines for prevention and control. Washington, D.C. Scientific Publication No. 548, 1994.

(14.) Organizacion Panamericana de la Salad. Nueva Generacion de Programas de Prevencion y Control del Dengue en las Americas. OPS/HCP/HCT/206/02. Programa de Enfermedades Transmisibles. Division de prevencion y Control de Enfermedades, octubre 2001.

Dr. Pelaez is an epidemiologist working at the Centro Provincial de Higiene y Epidemiologia de Ciudad Habana, Habana, Cuba. His work focuses on HIV and dengue.

Address for correspondence: Maria G. Guzman, Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, "Pedro Kouri" Tropical Medicine Intitute, Autopista Novia del Mediodia, Kin 6. P.O. Box Marianao 13. Habana. Cuba; fax: 53-7-2046051; email: lupe@ipk.sld.cu

Otto Pelaez, * Maria G. Guzman, ([dagger]) Gustavo Kouri, ([dagger]) Raul Perez, ([double dagger]) Jose L. San Martin, ([double dagger]) Susana Vazquez, ([dagger]) Delfina Rosario, ([dagger]) Regla Mora, * Ibrahim Quintana, (double dagger]) Juan Bisset, ([dagger]) Reynel Cancio, ([dagger]) Ana M Masa, * Osvaldo Castro, ([dagger]) Daniel Gonzalez, ([dagger]) Luis C. Avila, * Rosmari Rodriguez, ([dagger]) Mayling Alvarez, ([dagger]) Jose L. Pelegrino, ([dagger]) Lidice Bernardo, ([dagger]) and Irina Prado ([dagger])

* Centro Provincial de Higiene y Epidemiologia de Ciudad Habana, Habana, Cuba; ([dagger]) Instituto Medicina Tropical "Pedro Kouri"; and ([double dagger]) Viceministerio pare la Higiene y la Epidemiologia, Habana, Cuba

COPYRIGHT 2004 U.S. National Center for Infectious Diseases
COPYRIGHT 2004 Gale Group

Return to MASA syndrome
Home Contact Resources Exchange Links ebay