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Measles

Measles, also known as rubeola, is a disease caused by a virus of the genus Morbillivirus. more...

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Reports of measles go back to at least 700, however, the first scientific description of the disease and its distinction from smallpox is attributed to the Muslim physician Ibn Razi (Rhazes) 860-932 who published a book entitled "Smallpox and Measles" (in Arabic: Kitab fi al-jadari wa-al-hasbah). In 1954, the virus causing the disease was isolated, and licensed vaccines to prevent the disease became available in 1963.

Measles is spread through respiration (contact with fluids from an infected person's nose and mouth, either directly or through aerosol transmission), and is highly contagious - 90% of people without immunity sharing a house with an infected person will catch it. Airborne precautions should be taken for all suspected cases of measles.

The incubation period usually lasts for 10-12 days (during which there are no symptoms).

Infected people remain contagious from the appearance of the first symptoms until 3-5 days after the rash appears.

Symptoms

The classical symptoms of measles include a fever for at least three days duration, and the three C's - cough, coryza (runny nose) and conjunctivitis (red eyes). The fever may reach up to 40 degrees Celsius (105 Fahrenheit). Koplik's spots seen inside the mouth are pathognomic (diagnostic) for measles but are not often seen, even in real cases of measles, because they are transient and may disappear within a day of arising.

The rash in measles is classically described as a generalised, maculopapular, erythematous rash that begins several days after the fever starts. It starts on the head before spreading to cover most of the body. The measles rash also classically "stains" by changing colour to dark brown from red before disappearing later. The rash can be itchy.

Diagnosis

A detailed history should be taken including course of the disease so far, vaccination history, contact history, and travel history.

Clinical diagnosis of measles requires a history of fever of at least three days together with at least one of the three Cs above. Observation of Koplik's spots is also diagnostic of measles.

Alternatively, laboratory diagnosis of measles can be done with confirmation of positive measles IgM antibodies or isolation of measles virus RNA from respiratory specimens.

Positive contact with other patients known to have measles adds strong epidemiological evidence to the diagnosis.

Treatment

There is no specific treatment for uncomplicated measles. Patients with uncomplicated measles will recover with rest and supportive treatment.

Complications

Complications with measles are relatively common, ranging from relatively common and less serious diarrhea, to pneumonia and encephalitis (subacute sclerosing panencephalitis). Complications are usually more severe amongst adults who catch the virus.

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Progress in measles control—Zambia, 1999-2004
From Morbidity and Mortality Weekly Report, 6/17/05 by B. Chirwa

Zambia, a southern African country with estimated population of 11.6 million in 2005 (1), reported 1,698-23,518 measles cases annually during 1991-1999. During that period, measles was considered one of the five major causes of morbidity and mortality among children aged <5 years (2). During 1999-2004, the challenge of controlling measles led Zambia to try several strategies in succession. In addition to a single dose of measles vaccine offered at age 9 months through routine services, in 1999, measles supplemental immunization activities (SIAs) targeting children aged 9 months-4 years were held in four urban centers. Those activities were followed in 2000 by a subnational measles SIA targeting children aged 9 months-4 years in approximately half of the country's 72 districts. In 2003, Zambia adopted a strategy of accelerated measles control that included strengthening routine vaccination, providing a second opportunity for measles immunization for all children, and conducting case-based surveillance. As part of this strategy, a nationwide measles SIA targeting all children aged 6 months-14 years was conducted in 2003. This report summarizes progress in measles control in Zambia during 1999-2004, as measured through surveillance data, which demonstrates a marked reduction in measles transmission after the 2003 SIA.

Routine Vaccination

The routine vaccination program in Zambia provides a dose of measles vaccine to infants aged 9 months through fixed stations or through community outreach. The reported coverage with measles vaccine among children aged [less than or equal to] 1 year, as measured by the administrative method, was 74% in 1999 and 95% during 2000-2004 (Table). The administrative method for estimating vaccination coverage is calculated by dividing the reported number of vaccine doses administered by the number of children aged [less than or equal to] 1 year, as determined by the census and adjusted for annual growth; in Zambia, no adjustment is made for infant mortality. A 2002 cluster survey indicated routine 1-dose measles vaccine coverage of 84% among children aged [less than or equal to] 1 year. To further strengthen routine vaccinations, in January 2004, Zambia implemented the Reaching Every District (RED) strategy advocated by the World Health Organization (WHO) in the 10 districts with the highest number of unvaccinated children (3).

Supplemental Immunization Activities

Zambia conducted three measles SIAs during 1999-2003, which differed from each other in the age group targeted, geographic extent, and coverage achieved. The 1999 SIA targeted all children aged 9 months--4 years in the four urban districts of Kabwe, Kitwe, Lusaka, and Ndola, and achieved coverage of 81% as measured by the administrative method. The 2000 SIA focused on the eastern and northeastern border districts, targeted all children aged 9 months--4 years in 35 (49%) of the country's 72 districts, and achieved 91% coverage as measured by the administrative method. In June 2003, a nationwide SIA expanded the target population to all children aged 6 months-14 years and vaccinated 97% of the target population as measured by a vaccination coverage survey. This SIA also provided vitamin A supplementation and mebendazole anti-helminth treatment nationwide to children aged 6 months--4 years and insecticide-treated bed nets (ITNs) for malaria prevention and control to children in the same age group in one urban and four rural districts.

Surveillance

Measles is a notifiable disease in Zambia. The routine information system, including incidence and mortality data, was improved in 1998 with the addition of a nationwide district-based electronic system. Before July 2003, laboratory confirmation of cases was not performed routinely, and notifiable cases were those clinically suspected to be measles. Case-based measles surveillance with laboratory confirmation of each sporadic case or the first 5-10 outbreak cases was introduced after the 2003 SIA and is currently implemented nationwide. A national measles laboratory accredited by WHO provides routine enzyme-linked immunosorbent assay testing of serum specimens for measles IgM.

During 1999-2003, an average of 26,072 suspected cases of measles were reported annually in Zambia, ranging from 16,793 cases in 2003 to 33,628 cases in 2001 (Figure). After the SIA in June 2003, an 87% decline occurred in the number of reported measles cases in the second half of 2003 (July-December), when compared with the average number of cases for the same period during the preceding 4 years (2,315 versus 18,220). The downward trend continued in 2004, during which 3,425 suspected cases were reported. Of these, 831 (27%) had a blood specimen submitted for confirmatory testing; of these 831 cases, 34 (4%) were positive for IgM anti-body to measles. During 1999-2004, reported measles incidence by age group was threefold to fivefold higher among children aged <5 years, compared with persons aged [greater than or equal to] 5 years (Table). Comparing the reported incidence before and after the June 2003 SIA (i.e., 2002 versus 2004), the declines were similar among children aged <5 years (88%) and persons aged [greater than or equal to] 5 years (87%).

During 1999-2002, the annual average number of deaths attributed to measles was 217, with an average of 110 deaths occurring during the first half of the year (January-June) and an average of 107 deaths occurring during the second half of the year. In 2003, a total of 86 measles deaths were reported during the first half of the year, and 12 deaths were reported during the second half. No measles deaths were reported during the first half of 2004; three deaths were reported during the second half of that year. Reported measles deaths declined by 99% in 2004 compared with the annual average reported during 1999-2002.

Editorial Note: A principal objective of the WHO Global Measles Strategic Plan for 2001-2005 is to decrease measles mortality by 50%, compared with 1999 levels, by 2005 (4). In addition, WHO has recommended that all children be provided a second opportunity for measles vaccination either through SIAs or routine health services (5). During 1999-2004, Zambia improved measles control by strengthening routine vaccination, providing a second opportunity for measles immunization through SIAs, and enhancing measles surveillance.

Reported routine measles vaccine coverage increased >15% from 1999 to 2000, and has remained >90% in each of the preceding 5 years. This increase is attributable, in part, to 1) the twice-yearly Child Health Week immunization campaigns, which boosted routine vaccination by targeting unvaccinated children throughout the country, and 2) the drive to increase routine measles vaccination as a strategy to control measles epidemics. The reported increase in vaccination coverage might also be attributed, in part, to a change in population estimates. The 2000 census estimated approximately 10% fewer children aged [less than or equal to] 1 year compared with 1999 estimates, which had been projected from the 1990 census. Although the coverage survey conducted in 2002 suggests reported measles vaccination coverage might be an overestimate of true coverage, routine coverage likely has increased in recent years as a result of increased program activities.

Zambia offered a second opportunity for measles vaccination through SIAs on three occasions during 1999-2004. However, measles morbidity and mortality declined substantially only after the most recent SIA in June 2003, which expanded the previous target population (i.e., children aged 9 months-4 years in selected geographic regions) to all children aged 6 months-14 years nationwide. This experience is similar to what has occurred in other African countries in the sub-Saharan region, where SIAs restricted to children aged <5 years or conducted subnationally resulted in transient decreases only in the targeted age groups and areas (2,6-8). The most likely explanations for this are: 1) subnational campaigns allow susceptible children to remain in geographic regions not targeted by SIAs, and population mixing then introduces these susceptible children to vaccinated regions, thus allowing virus transmission to persist; and 2) a substantial proportion of persons aged >5 years remain susceptible to measles, providing opportunity for ongoing transmission of virus both in this age group and to susceptible younger children. Approximately 50% of measles cases reported in Zambia during 1999-2003 occurred in children aged [greater than or equal to] 5 years.

Through the global initiative to eradicate polio-myelitis, Zambia has strengthened its vaccine delivery and surveillance systems and is now applying this capacity toward measles-control strategies. Case-based measles surveillance has been integrated with acute flaccid paralysis surveillance, and a reference laboratory has been established to provide confirmatory testing of serologic samples from suspected measles cases. The quality of measles case-based surveillance is monitored by two key indicators, the percentage of suspected measles cases with a blood specimen (24% in 2004; target: 80%) and the proportion of districts investigating at least one suspected measles case with a blood specimen per year (74% in 2004; target: 80%).

Zambia achieved near-zero measles mortality and markedly reduced measles incidence after the 2003 national campaign. Routine vaccination and vaccine-preventable disease surveillance in Zambia is funded by the Zambian Ministry of Health and its partners (e.g., WHO, UNICEF, Government of Japan, and the Global Alliance for Vaccines and Immunization). The 2003 national measles SIA was funded by the Measles Partnership*. Bed net distribution was supported by the American Red Cross, the International Federation of Red Cross, and NETMARK, a malaria-related project of the Academy for Educational Development. To sustain these gains in measles control, Zambia must maintain high rates of routine measles vaccination (i.e., >90%), consider adding a second dose of measles vaccine to the routine vaccination schedule, work to sustain the quality of surveillance, and plan for a follow-up nationwide SIA to be held during 2006-2007.

* In 2003, the Measles Partnership included the American Red Cross, the United Nations Foundation, WHO, UNICEF, Right to Play, and CDC.

References

(1.) Central Office of Statistics. Zambia 2000 census of population and housing. Lusaka, Zambia: Central Office of Statistics; 2003.

(2.) CDC. Measles incidence before and after supplementary vaccination activities--Lusaka, Zambia, 1996-2000. MMWR 2001;50:513-6.

(3.) Central Board of Health. Child health annual report 2004. Lusaka, Zambia: Central Board of Health; 2005.

(4.) World Health Organization, United Nation's Children's Fund. Measles mortality reduction and regional elimination strategic plan 2001-2005. Geneva, Switzerland: World Health Organization; 2001.

(5.) World Health Organization. Strategies for reducing global measles mortality. Wkly Epidemiol Rec 2000;75:409-16.

(6.) Otten MW, Okwo-Bele JM, Kezaala R, Biellik R, Eggers R, Nshimirimana D. Impact of alternative approaches to accelerated measles control: experience in the African Region, 1996-2002. J Infect Dis 2003;187:S36-S43.

(7.) Cliff J, Simango A, Augusto O, Van der Paal L, Biellik R. Failure of targeted urban supplemental measles vaccination campaigns (1997-1999) to prevent measles epidemics in Mozambique (1998-2001). J Infect Dis 2003;187:S51-S57.

(8.) Munyoro MN, Kufa E, Biellik R, Pazvakavambawa IE, Cairns KL. Impact of a nationwide measles vaccination campaign among children aged 9 months to 14 years, Zimbabwe, 1998-2001. J Infect Dis 2003; 187:S91-S96.

Reported by: B Chirwa, V Mukonka, M Katepa, P Kalesha, Central Board of Health, Lusaka, Zambia. D Nshimirimana, A Onyeze, S Anyangwe, E Maganu, R Groves, World Health Organization. R Kezaala, KL Cairns, Global Measles Br, CDC.

COPYRIGHT 2005 U.S. Government Printing Office
COPYRIGHT 2005 Gale Group

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