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Multiple chemical sensitivity

Multiple chemical sensitivity (MCS), also known as "20th Century Syndrome", "Environmental illness", "Sick Building Syndrome", Idiopathic Environmental Intolerance (IEI), can be defined as a "chronic, recurring disease caused by a person's inability to tolerate an environmental chemical or class of foreign chemicals" according to the NIH National Institute of Environmental Health Sciences web site. more...

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Cullen , et al, of Yale Environmental Medicine have published a definition of MCS, making diagnosis possible. Yale Environmental Health provides a comprehensive evaluation, considering differential diagnosis as well Yale Environmental Health Clinical Services.

MCS etiology is hotly debated among physicians. Professionals are divided: some believe that MCS is a physical illness with a yet-to-be-determined mechanism, some believe that MCS is the result of increase in exposure to irritants or a toxic injury, some believe that MCS is psychosomatic. Despite this debate, however, there is consensus that patients who complain of symptoms are recommended to avoid irritants as best as possible. Respect in care and recommendation of avoidance of irritants is now standard protocol recommended by the American Medical Association.

Several chemical-producing companies, especially producers of pesticides, have also funded studies that have cast doubts on the existence and cause of MCS.

Just as physicians debate etiology, those with MCS do not all agree on causation. While many with MCS believe that they have been injured by overexposure to chemicals, some believe that they have developed an intolerance over time, and still others are uncertain as to the cause and are open to a yet-to-be-determined mechanism. What is clear and agreed upon is that exposure to chemical irritants precipitates sometimes disabling symptoms such as migraine headache, sinus congestion, itchy eyes and throat, nausea and vomiting.

MCS is a non-coded medical diagnosis in the United States. Conventional medicine does not typically recognize this diagnosis, because to date there is no definitive test for diagnosis or proven scientific mechanism. Symptoms may be explainable by allergic, metabolic, enzymatic, inflammatory,infectious, or psychological mechanism.

Preliminary scientific testing has been unable to validate the correlation of symptoms with exposure to chemicals. Because the nature and cause(s) of MCS are still unanswered, effective testing may not yet be available. Complications may include propellants and other chemicals in the testing environment. In one blinded test, patients appeared to show no reaction to suspected substances. The same patients also seemed to react to saline solution injections and purified air injected into their environment. However, there has not been sufficient analysis to challenge or verify these tests.

Allergist Theron G. Randolph (1906-1995) is generally seen as the 'inventor' of the term and introducing this condition to the public. It was he who first speculated that exposure to modern synthetic chemicals was the cause. Allergic reactions to minute traces of chemicals goes against what is known about the correlation between dose and effect. Randolph, however, theorized that the human body is like a barrel filling up with small or even minute doses of chemicals until it is full. Any further exposure will then cause allergic reactions, like the straw that broke the camel's back. Science recognizes that there are chemicals that build up in the body (such as mercury), but these do not cause allergic reactions. They can, though, cause organ failure, such as failure of the liver (which is involved in storing these chemicals) or the kidneys (involved in filtering them out). Some chemicals are also stored in body fat. These effects have never been found in MCS patients, either suggesting that they actually do not suffer from the effects of chemicals or that there is another mechanism (possibly the one Randolph proposed) to blame for their symptoms. People who treat MCS generally identify themselves as "clinical ecologists", and many belong to the American Academy of Environmental Medicine, which Randolph founded in 1965 as the Society for Clinical Ecology. Clinical Ecology is not a recognised field of medical science.

Read more at Wikipedia.org


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Multiple chemical sensitivity
From Gale Encyclopedia of Medicine, 4/6/01 by Bethany Thivierge

Definition

Multiple chemical sensitivity, also known as MCS syndrome or simply MCS, is a disorder in which a person develops symptoms from exposure to chemicals in the environment. With each incidence of exposure, lower levels of the chemical will trigger a reaction and the person becomes increasingly vulnerable to reactions triggered by other chemicals.

Description

Multiple chemical sensitivity typically begins with one high-dose exposure to a chemical, but it may also develop with long-term exposure to a low level of a chemical. Chemicals most often connected with MCS include: formaldehyde; pesticides; solvents; petrochemical fuels such as diesel, gasoline, and kerosene; waxes, detergents, and cleaning products; latex; tobacco smoke; perfumes and fragrances; and artificial colors, flavors, and preservatives. People who develop MCS are commonly exposed in one of the following situations: on the job as an industrial worker; residing or working in a poorly ventilated building; or living in conditions of high air or water pollution. Others may be exposed in unique incidents.

Because MCS is difficult to diagnose, estimates vary as to what percentage of the population develops MCS. However, most MCS patients are female. The median age of MCS patients is 40 years old, and most experienced symptoms before they were 30 years old.

Causes & symptoms

Chemical exposure is often a result of indoor air pollution. Buildings which are tightly sealed for energy conservation may cause a related illness called sick building syndrome, in which people develop symptoms from chronic exposure to airborne environmental chemicals such as formaldehyde from the furniture, carpet glues, and latex caulking. A person moving into a newly constructed building, which has not had time to degas, may experience the initial high-dose exposure that leads to MCS.

The symptoms of MCS vary from person to person and are not chemical-specific. Symptoms are not limited to one physiological system, but primarily affect the respiratory and nervous systems. Symptoms commonly reported are headache, fatigue, weakness, difficulty concentrating, short-term memory loss, dizziness, irritability and depression, itching, numbness, burning sensation, congestion, sore throat, hoarseness, shortness of breath, cough, and stomach pains.

Diagnosis

Multiple chemical sensitivity is a twentieth-century disorder, becoming more prevalent as more man-made chemicals are introduced into the environment in greater quantities. It is especially difficult to diagnose because it presents no consistent or measurable set of symptoms and has no single diagnostic test or marker. Physicians are often unaware of MCS as a condition. They may be unable to diagnose it, or may misdiagnose it as another degenerative disease, or may label it as a psychosomatic illness (a physical illness that is caused by emotional problems). Their lack of understanding generates frustration, anxiety, and distrust in patients already struggling with MCS. However, a new specialty of medicine is evolving to address MCS and related illnesses: occupational and environmental medicine. A physician looking for MCS will take a complete patient history and try to identify chemical exposures.

Treatment

While doctors may recommend antihistamines, analgesics, and other medications to combat the symptoms, the most effective treatment is to avoid those chemicals which trigger the symptoms. This becomes increasingly difficult as the number of offending chemicals increases, and people with MCS often remain at home where they are able to control the chemicals in their environment. This isolation often limits their abilities to work and socialize, so supportive counseling may also be appropriate.

Alternative treatment

Some MCS patients find relief with detoxification programs of exercise and sweating, and chelation of heavy metals. Others support their health with nutritional regimens and immunotherapy vaccines. Some undergo food-allergy testing and testing for accumulated pesticides in the body to learn more about their condition and what chemicals to avoid. Homeopathy and acupuncture can give added support to any treatment program for MCS patients. Botanical medicine can help to support the liver and other involved organs.

Prognosis

Once MCS sets in, sensitivity continues to increase and a person's health continues to deteriorate. Strictly avoiding exposure to triggering chemicals for a year or more may improve health.

Prevention

Multiple chemical sensitivity is difficult to prevent because even at high-dose exposures, different people react differently. Ensuring adequate ventilation in situations with potential for acute high-dose or chronic low-dose chemical exposure, as well as wearing the proper protective equipment in industrial situations, will minimize the risk.

Key Terms

Degas
To release and vent gases. New building materials often give off gases and odors and the air should be well circulated to remove them.
Sick building syndrome
An illness related to MCS in which a person develops symptoms in response to chronic exposure to airborne environmental chemicals found in a tightly sealed building.

Further Reading

For Your Information

    Books

  • Hu, Howard, and Frank E. Speizer. "Specific Environmental and Occupational Hazards." In Harrison's Principles of Internal Medicine, 14th ed., edited by Anthony S. Fauci, et al. New York: McGraw-Hill, 1998.

    Periodicals

  • Sparks, P.J., et al. "Multiple Chemical Sensitivity Syndrome: A Clinical Perspective." Journal of Occupational Medicine 36(1994): 718.

    Organizations

  • American Academy of Environmental Medicine. P.O. Box CN 1001-8001, New Hope, PA 18938. (215) 862-4544.

Gale Encyclopedia of Medicine. Gale Research, 1999.

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