Patterson syndrome, pseudoleprechaunism
An extremely rare syndrome, first mistaken as Donohue Syndrome (also known as Leprechaunism). Described by Patterson and Watkins, 1962.
It is characterized by the patient having bizarre look, masqueraded as Leprechaunism. It primarily affects the connective tissue and the neuroendocrine system, giving rise to bronzed hyperpigmentation, cutis laxa of the hands and feet, bodily disproportion, severe mental retardation, and major bony deformities.
Radiographs reveals a characteristic generalised skeletal dysplasia.
It comprises endocrine abnormality hyperadrenocorticism, cushingoid features, and diabetes mellitus. One other case has shown premature adrenarche.
The pathogenesis and aetiology of the Patterson syndrome was unknown, 1981.
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