Within the syndrome there are bone fractures and deformity of the legs, arms and skull, different pigment patches on the skin, and early puberty with increased rate of growth. Polyostotic fibrous dysplasia is usually caused by mosaicism for a mutation in a gene called GNAS1.

Polyostotic Fibrous Dysplasia has different levels of severity. For example one child may be entirely healthy with no outward evidence of bone or endocrine problems, enter puberty at close to the normal age and have no unusual skin pimgentation. The complete opposite of that would be children who are diagnosed in early infancy with the obvious bone disease and obvious increased endocrine secretions from several glands.

Approximately 20-30% of fibrous dysplasias are polyostotic and two thirds of patients are polyostotic before the age of ten.

Read more at Wikipedia.org

• [List your site here Free!]



	A customised replacement for polyostotic fibrous dysplasia of the upper femur: A 51-YEAR FOLLOW-UP We report the case of a 12-year-old boy with polyostotic fibrous dysplasia of the upper femur in whom a massive customised polyethylene prosthesis functioned ... From Journal of Bone and Joint Surgery, 1/1/05 by Dunstan, E

	Hydroxyapatite cranioplasty in fibrous dysplasia of the skull - Brief Article Hydroxyapatite cranioplasty in fibrous dysplasia of the skull. From Ear, Nose & Throat Journal, 1/1/01 by Andrew Vories

	Fibrous dysplasia of the frontal sinus Fibrous dysplasia is a benign idiopathic skeletal disorder that occurs when normal cancellous bone is replaced by abnormal fibrous tissue. The fibrous ... From Ear, Nose & Throat Journal, 1/1/04 by Rafael Rojas

	Ethmoid fibrous dysplasia with anterior skull base and intraorbital extension Fibrous dysplasia is an idiopathic disorder in which medullary bone is replaced with fibrous and osseous tissue. It is an indolent expansile mass that ... From Ear, Nose & Throat Journal, 10/1/05 by Edwin K. Chan

	Fibrous dysplasia of the temporal bone: Report of a case and a review of its characteristics - Brief Article - Statistical Data Included Abstract Fibrous dysplasia is an uncommon benign disorder of unknown etiology. It represents a disturbance of normal bone development--specifically ... From Ear, Nose & Throat Journal, 1/1/00 by Chariton E. Papadakis

	FIBROUS DYSPLASIA: 64 CASES Purpose: Fibrous dysplasia is a rare condition accounting for about 1% of benign bone tumours. Both mono-and polyostotic dysplasia is described. Treatment ... From Journal of Bone and Joint Surgery, 1/1/04 by Karray, N

	Fibrous dysplasia of bone - Pathology Clinic Fibrous dysplasia (fibro-osseous metaplasia) is one of a diverse group of diseases that are characterized by alterations in bone growth. It is a developmental, ... From Ear, Nose & Throat Journal, 4/1/03 by Brenda L. Nelson

	Fibrous dysplasia of bone Fibrous Dysplasia of Bone Fibrous dysplasia of bone is a disorder of unknown etiology in which skeletal aberrations constitute the cardinal feature. The condition is often monostotic but may be poly From American Family Physician, 3/1/89 by Brett E. Stompro

Home

Contact

Resources

Exchange Links

ebay