Pyruvate kinase deficiency

Pyruvate Kinase Deficiency is an inherited autosomal recessive disorder which affects the survival of red blood cells, causing them to break down easily. This leads to anemia and liver failure among affected dogs. more...

This inherited disease is characterised by signs of anemia, low energy, exercise intolerance, jaundice, yellowing of the white part of the eye, and persistent gallstones. Treatment can include a blood transfusion or removal of the spleen. Treatment is usually effective in reducing the severity of the symptoms, but most canines affected with PK are likely to die between ages 1 and 4.

Read more at Wikipedia.org