Supercentenarian Ann Pouder (8 April 1807 – 10 July 1917) photographed on her 110th birthday. A heavily lined face is common in human senescence.
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Premature aging

In biology, senescence is the combination of processes of deterioration which follow the period of development of an organism. For the science of the care of the elderly, see gerontology; for experimental gerontology, see life extension. more...

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The word senescence is derived from the Latin word senex, meaning "old man" or "old age."

Cellular senescence is the phenomenon where cells lose the ability to divide. In response to DNA damage (including shortened telomeres) cells either senesce or self-destruct (apoptosis) if the damage cannot be repaired. Organismal senescence is the aging of whole organisms. The term aging has become so commonly equated with senescence that the terms will be used interchangeably in this article.

Aging is generally characterized by the declining ability to respond to stress, increasing homeostatic imbalance and increased risk of disease. Because of this, death is the ultimate consequence of aging. Differences in maximum life span between species correspond to different "rates of aging". For example,Genetics make a mouse elderly at 3 years and a human elderly at 90 years. These genetic differences relate to the efficiency of DNA repair, antioxidant enzymes, rates of free radical production, etc.

Some researchers in gerontology (specifically biogerontologists) regard aging itself as a "disease" that may be curable, although this view is controversial. To those who accept the view, aging is an accumulation of damage to macromolecules, cells, tissues and organs. Advanced biochemical and molecular repair technologies may be able to fix the damage we call aging (thereby curing the disease and greatly extending maximum lifespan). People who hope to wish to extend human maximum life span through science are called life extensionists.

Genetic and environmental interventions are known to affect the life span of model organisms. This gives many hope that human aging can be slowed, halted, or reversed. Dietary calorie restriction, by 30 percent for example, extends the life span of yeast, worms, flies, mice, and monkeys. Several genes are known to be necessary for this extension, and modification of these genes is also sufficient to produce the same effect as diet. Resveratrol, a polyphenol found in the skin of red grapes, has been shown to extend the lifespan of yeast, worms, and flies.

Theories of aging

The process of senescence is complex, and may derive from a variety of different mechanisms and exist for a variety of different reasons. However, senescence is not universal, and scientific evidence suggests that cellular senescence evolved in certain species as a mechanism to prevent the onset of cancer. In a few simple species, senescence is negligible and cannot be detected. All such species have no "post-mitotic" cells; they reduce the effect of damaging free radicals by cell division and dilution. Such species are not immortal, however, as they will eventually fall prey to trauma or disease. Moreover, average lifespans can vary greatly within and between species. This suggests that both genetic and environmental factors contribute to aging.

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Anti-inflammatory diet: the right foods can protect you from Alzheimer's, obesity, heart disease, and even premature aging
From Natural Health, 9/1/05 by Mollly Siple

CUT YOUR FINGER SLICING ONIONS and the area will swell, redden, and heat up. This type of acute inflammatory response is the body's reaction to trauma, and it's an essential part of the healing process. But chronic inflammation caused by more subtle forms of trauma can undermine your health every day.

Long-term ailments, highly processed foods, and ongoing exposure to environmental toxins can result in the kind of persistent, low-grade inflammation researchers are linking to premature aging, heart disease, M.S., R.D. diabetes, Alzheimer's, psoriasis, rheumatoid arthritis, and cancer.

Many foods in the standard American diet aggravate inflammation (see our list of fire feeders on page 43), including refined white flour and sugar, red meat, dairy products, fast food, and food additives. "For someone on such a diet, the body can become like a dry field of grass that is waiting for a match," says Jack Challem, author of The Inflammation Syndrome. "Once the match lights, it's hard to put out the fire."

And it's not just your health that gets singed. Chronic inflammation can make you look old before your time. "Low-grade, systemic inflammation drives aging," says Ronald E. Hunninghake, M.D., author of User's Guide to Inflammation, Arthritis, and Aging. "'Inflamaging' is a term coined by Italian researchers to highlight this association."

The good news is that changing your diet can help prevent or even reverse the process. "Our daily diet and the foods we eat are the most effective-and safest--means of preventing inflammation," says Challem. "The body is quite capable of making its own anti-inflammatory compounds as long as we eat the right foods."

put out the fire

A PROTECTIVE MENU is easier to assemble at home, where you can control the ingredients, including cooking oils. Start with the recipes here, and follow our guide to anti-inflammatory foods, especially if you have inflammation risk factors like elevated levels of cholesterol, triglycerides, or C-reactive protein (see "Are You Going Down in Flames?" on page 40).

Polyphenols. These inflammation-dampening phytochemicals are found in colorful kits like blueberries, blackberries, strawberries, and raspberries, which also contain flavonoids called anthocyanins that protect against oxidative damage. Keep no-sugar-added cranberry juice (such as Ocean Spray's 100% Cranberry Blend) on hand, along with jars of sour cherries.

Quercetin. This anti-inflammatory compound and natural histamine inhibitor is the most powerful kind of flavonoid. Excellent sources include red grapes, red and yellow onions, garlic, broccoli, and apples.

Antioxidants. These nutrients protect the body from free radicals, which trigger inflammation. Carrots and orange winter squash supply beta carotene; bell peppers are high in vitamin C; tomatoes are rich in lycopene. Leafy greens, such as spinach and kale, are also abundant in antioxidants.

Omega-3 fatty acids, Thanks to anti-inflammatory properties, omega-3s provide significant benefit to patients with chronic inflammatory diseases, according to a report in the Journal of the American College of Nutrition. The most potent omega-3s are found in seafood, especially coldwater fish like salmon (preferably wild), tuna, and mackerel. Stock your pantry with canned anchovies and sardines and jars of marinated herring to add to meals. Vegetarian sources of omega-3s include flaxseed oil, dark greens, and walnuts.

Oleic acid. Almonds and macadamias (or their oils) contain this omega-9 fatty acid, which helps omega-3s do their job. Olive oil, which contains oleic acid, is best for everyday cooking. If you prefer safflower or sunflower oil, which are normally placed in the pro-inflammatory camp, buy high-oleic versions. "Balanced" oils, such as those from Spectrum Naturals, are available in minimally processed forms, always a better health choice than refined oils. Canola oil, however, is a refined oil that contains a noteworthy amount of omega-3s and oleic acid.

Curcumin. Turmeric, an Indian spice that gives curry its orange-yellow color, contains curcumin, one of the most powerful anti-inflammatory compounds in nature, says Michael T. Murray, N.D., author of Encyclopedia of Natural Medicine. (Other spices with anti-inflammatory properties are ginger and rosemary.)

ARE YOU GOING DOWN IN FLAMES?

How can you tell if you suffer from chronic inflammation? One indicator is an elevated blood level of C-reactive protein, which the body produces in response to inflammation. Researchers at Brigham and Women's Hospital in Boston and Harvard Medical School monitored over 28,000 healthy, postmenopausal women for three years and found that CRP was the strongest predictor of heart disease compared with 11 other links, including LDL cholesterol.

Although not currently part of routine lab work, a high-sensitivity CRP test is in order for anyone with a risk of developing a disease linked to inflammation. "If you have a family history of heart disease, or an inflammatory condition such as gingivitis--especially if you smoke--ask your physician for a CRP test," advises Ronald E. Hunninghake, M.D. "The CRP test is appropriate for people of any age who are at risk."

FOODS THAT FEED THE FIRE

Wheat eggs, milk, soybeans, yeast, and meat are among the most common inflammatory foods. Meat contains inflammation-promoting arachidonic acid; beef has the highest content, double the amount in lamb, pork, or chicken. Eggs and dairy products also contain arachidonic acid, but in lower amounts.

Ironically, well-intentioned advice to consume vegetable oils rather than saturated-fat-rich butter has led to a multifold increase in the intake of omega-6 fatty acids, which promote inflammation. Popular vegetable oils such as sunflower, corn, peanut, soy, cottonseed, and (regular) safflower are high in inflammatory omega-6s.

Choose free-range chicken, turkey, or duck, which receive a natural grass feed rich in anti-inflammatory omega-3 fatty acids. Dairy is fine to eat unless it upsets your system, which could trigger inflammation. Make a point of buying eggs with extra omega-3s. And avoid foods that cause inflammation provoking spikes in blood sugar, such as sugary drinks, refined white flour, and fried potatoes

COPYRIGHT 2005 Weider Publications
COPYRIGHT 2005 Gale Group

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