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Sulfanilamide

Sulfonamides, also known as sulfa drugs, are synthetic antimicrobial agents derived from sulfonic acid. In bacteria, these drugs are competitive inhibitors of para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. This reaction is necessary in these organisms for the synthesis of folic acid. more...

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The first sulfonamide was trade named prontosil. The first experiments with prontosil began in 1932 by the German chemist Gerhard Domagk, and the results were published in 1935 (after his employer, IG Farben, had obtained a patent on the compound). Prontosil was a red azo dye, and in mice had a protective action against streptococci. It had no effect in the test tube, and only exerted an antibacterial effect in the live animal itself. And, with war on the horizon, there was interest among the Allies to break the German patent.

Soon it was discovered (1936) that prontosil's active agent was a smaller, more effective compound known as sulfanilamide:

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Sulfanilamide therapy of bacterial infections,: With special reference to diseases caused by hemolytic streptococci, pneumococci, meningococci and gonococci, $89.50 Only 2% will have a second reaction to sulfa Rx: weigh risks.(News) : An article from: Family Practice News $5.95
Bibliography on sulfanilamides as used in treatment of pneumococcic pneumonias Sulfanilamide and related compounds in general practice (The General practice manuals)
Sulfanilamide therapy of bacterial infections The clinical use of sulfanilamide, sulfapyridine, sulfathiazole, sulfaguanidine, and sulfadiazine in the prophylaxis and treatment of infections,
The isolation and cultivation from the human leprous lesion of the Duval chromogenic acid-fast bacillus and the "in vitro" action of sulfanilamide on it and other acid-fast organisms Antigenic properties of sulfanilamide in protein combination
On the concentrations of some sulfanilamide derivatives in different organs and tissue structures;: A histo-pharmacological study by means of flourescence ... tissues (Acta physiologica Scandinavia) Experimental research on the possibility of the distinction between plants and animals according to the effect of sulfanilamide upon their cells

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