Chemical structure of sumatriptan
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Sumatriptan

Sumatriptan (Imitrex®, Imigran®) is a triptan drug originally developed by Glaxo for the treatment of migraine headaches. Several dosage forms for sumatriptan have been approved, including tablets, solution for injection, and nasal inhalers. Sumatriptan was the first triptan available (in 1993), and is available only by prescription in the United States. more...

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Mode of action

Sumatriptan is a 5-HT (5-HT1D) agonist. The specific receptor subtype it activates is present in the cranial and basilar arteries. Activation of these receptors causes vasoconstriction of those dilated arteries. Sumatriptan is also shown to decrease the activity of the trigeminal nerve.

Pharmacokinetics

Sumatriptan is administered in several forms; tablets, subcutaneous injection, and nasal spray. Oral administration (as succinate) suffers from poor bioavailability, partly due to presystemic metabolism — some of it gets broken down in the stomach and bloodstream before it reaches the target arteries. A new rapid-release tablet formulation has the same bioavailability, but the maximum concentration is achieved on average 10-15 minutes earlier. When injected, sumatriptan is faster acting (usually within a minute), but the effect lasts for a shorter time. Sumatriptan is metabolised primarily by monoamine oxidase A into an indole acetic acid analogue, part of which is further conjugated with glucuronic acid. These metabolites are excreted in the urine and bile.

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Migraine may masquerade as 'sinus' headache: sumatriptan effective. (Clinical Rounds). : An article from: Family Practice News $5.95 Pain-free results with sumatriptan taken at the first sign of migraine pain: 2 randomized, double-blind, placebo-controlled studies : An article from: Mayo Clinic Proceedings $20.00
OTC product beats sumatriptan for early migraine: acetaminophen/aspirin/caf feine. (over-the-counter).(Pain Medicine) : An article from: Clinical Psychiatry News $5.95 Triptans Not Advised for Migraines in Pregnancy. : An article from: Family Practice News $5.95
Effectiveness of sumatriptan in reducing productivity loss due to migraine: Results of a randomized, double-blind, placebo-controlled clinical trial : An article from: Mayo Clinic Proceedings $20.00 For tension headache, 100 mg of sumatriptan far exceeds placebo.(Pain Medicine)(research report) : An article from: Clinical Psychiatry News $5.95
Cost-effectiveness and cost-benefit of sumatriptan in patients with migraine : An article from: Mayo Clinic Proceedings $20.00 Drug update: moderately severe migraine headaches. (RX). : An article from: Internal Medicine News $5.95
Try ibuprofen, then sumatriptan for migraine: regular sleep is great prevention.(Children's Health) : An article from: Family Practice News $5.95 Topical sumatriptan offers fast migraine relief: fewer side effects than injection.(Clinical Rounds) : An article from: Family Practice News $5.95

Sumatriptan treatment of menstrually related migraine
About 60 percent of women who have migraine report a correlation of migraine attacks with the onset of menstruation. Nett and colleagues studied the ...
Injectable sumatriptan works after oral form fails
VANCOUVER, B.C. -- When migraine patients who need sumatriptan to abort their headaches fail to respond to it, they should try the injectable form, Seymour Diamond, M.D., said at the annual meeting
Atrial fibrillation associated with sumatriptan
A 34 year old man with a history of migraine presented with palpitations after taking sumatriptan by nasal spray for a severe headache. Examination was unremarkable apart from atrial fibrillation,
Sumatriptan relieves attacks: that tension headache may actually be a migraine
SAN FRANCISCO -- Of patients with self-described or physician-diagnosed tension or stress headache, 88% actually turned out to meet International Headache ...
Sumatriptan 25-mg Suppository
METHOD OF PREPARATION Note: It is generally recommended to prepare sufficient material for one or two additional suppositories due to loss during preparation.
Overcoming GI stasis: new fast-dissolving sumatriptan relieves migraine
RANCHO MIRAGE, CALIF. -- A new rapid-release formulation of sumatriptan has proved superior to placebo at relieving migraines within 2 hours when taken ...
Pharmacokinetics in healthy volunteers of sumatriptan 25-mg oral tablet versus 25-mg extemporaneous suppository
Abstract The pharmacokinetics of an extemporaneous 25-mg suppository formulation of sumatriptan were compared to those of the marketed 25-mg oral tablet.
OTC product beats sumatriptan for early migraine: study of 171 patients - Clinical Rounds
CHICAGO--The first prospective trial pitting an over-the-counter product against a prescription medication gave the edge to the OTC product for the earliest treatment of migraine headache. Result

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