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Tourette syndrome

Tourette syndrome — also called Tourette's syndrome, Tourette's disorder, or Gilles de la Tourette syndrome — is a neurological or neurochemical disorder characterized by tics: involuntary, rapid, sudden movements or vocalizations that occur repeatedly in the same way. more...

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The eponym was bestowed by Jean-Martin Charcot after and on behalf of his resident, Georges Gilles de la Tourette, (1859 - 1904), French physician and neurologist.


Symptoms include multiple motor and one or more vocal tics present at some time during the disorder although not necessarily simultaneously; the occurrence of tics many times a day (usually in bouts) nearly every day or intermittently throughout a span of more than one year; the periodic change in the number, frequency, type and location of the tics, and in the waxing and waning of their severity; symptoms disappearing for weeks or months at a time; and onset before the age of 18.

Vocal tics may fall into various categories, including echolalia (the urge to repeat words spoken by someone else after being heard by the person with the disorder), palilalia (the urge to repeat one's own previously spoken words), lexilalia (the urge to repeat words after reading them) and, most controversially, coprolalia (the spontaneous utterance of socially objectionable or taboo words or phrases, such as obscenities and racial or ethnic slurs). However, according to the Tourette Syndrome Association, Inc., only about 10% of TS patients suffer from this aspect of the condition. There are many other vocal tics besides those categorized by word repetition: in fact, a TS tic can be almost any possible short vocalization, with common vocal tics being throat clearing, coughing, sniffing, grunts, or moans. Motor tics can be of an endless variety and may include hand-clapping, neck stretching, shoulder shrugging, eye blinking, and facial grimacing.

The term "involuntary" has been used to describe TS tics, since it is known that most people with TS do have limited control over the expression of symptoms. Immediately preceding tic onset, individuals with TS experience what is called a "premonitory urge," similar to the feeling that precedes yawning. The control which can be exerted (from seconds to hours at a time) may merely postpone and exacerbate the ultimate expression of the tic. Children may be less aware of the premonitory urge associated with tics than are adults, but their awareness tends to increase with maturity. Tics are experienced as irresistible (like a yawn or sneeze or itch) and must eventually be expressed. People with TS often seek a secluded spot to release their symptoms after delaying them in school or at work. It is not uncommon for children to suppress tics during a visit to the doctor or while at school. Typically, tics increase as a result of tension or stress (but are not solely caused by stress) and decrease with relaxation or concentration on an absorbing task. In fact, neurologist and writer Oliver Sacks has described a man with severe TS who is both a pilot and a surgeon.


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Tourette Syndrome
From Gale Encyclopedia of Childhood and Adolescence, 4/6/01

Tourette syndrome (TS) affects roughly one in every 2,500 persons. The incidence of the condition is at least three times higher in males than in females. Historically, Tourette syndrome has been a largely misunderstood condition; it has been identified as demonic possession, epilepsy , schizophrenia , and other mental disorders and was formerly thought to be the result of emotional problems due to faulty childrearing. The condition was first identified as a physiological disorder in 1885 by the French neurologist Gilles de la Tourette. Although the causes of Tourette syndrome are still not fully understood, researchers have made substantial progress in understanding and treating the condition.


Tics --sudden, repetitive, involuntary muscular movements--are the hallmark of Tourette syndrome, appearing in two forms: motor and vocal tics. Motor tics are uncontrollable body movements, such as blinking, grimacing, shrugging, or tossing one's head. Vocal tics, which involve the muscles that produce speech, take the form of uncontrolled speech and involuntary noises, including snorting, hissing, yelping, sniffing, grunting, throat-clearing, and yelling. For a diagnosis of Tourette syndrome to be made, the Diagnostic and Statistical Manual (DSM-IV) of the American Psychiatric Association specifies criteria, including multiple motor tics and at least one vocal tic, occurring numerous times every day or almost daily for a period of over one year, with no tic-free period longer than three months, and onset of symptoms before the age of 18. There are two basic types of tics: simple and complex. Simple tics are isolated movements (such as blinking, kicking, or twitching) that involve only one part of the body. Complex tics are more involved and take the form of recognizable actions, such as poking, hitting, biting, and grooming behaviors (such as smoothing one's hair). They also include imitating the actions of others and making involuntary obscene gestures. Complex vocal tics involve recognizable words (or animal sounds) as opposed to simple noises. These may include the repetition of short phrases, such as "Oh, boy," the repetition of a single word, repetition of the words of others (echolalia), or involuntary swearing (coprolalia), which is one of the most publicized symptoms of the disorder, although it affects fewer than 10% of people with TS.

Besides tics, there are several types of behavior often associated with Tourette syndrome. At least half the persons affected with TS show symptoms of obsessive compulsive disorder (OCD), a psychological condition that involves repeated intrusive and senseless thoughts (obsessions) and repetitive behavior (compulsions) intended to stop them. An obsession may be an ordinary but inappropriately intense desire (such as a preoccupation with visiting a certain store) or an outlandish idea, such as a wish to walk across the dinner table or touch a stranger. Compulsions are pointless activities that a person with OCD can't help repeating, such as turning lights on and off, counting things over and over, or arranging objects in a certain pattern. OCD symptoms can be extremely debilitating, taking time away from normal pursuits, including schoolwork and social activities. The other major behavior disorder associated with Tourette syndrome is attention deficit/hyperactivity disorder (ADHD), whose symptoms include hyperactivity, inability to concentrate, and impulse control disorders . Some persons with Tourette syndrome have both OCD and ADHD.

Causes and onset of Tourette syndrome

Tourette syndrome, once thought to be caused by psychological problems, is now known to be a genetic disorder. About 90% of children with TS have a family history of TS or related disorders, such as other conditions involving tics. Some persons are genetic carriers of Tourette syndrome without actually having symptoms themselves (these are almost always females; roughly 99% of males who carry the genetic tendency toward the disorder develop symptoms). The biological basis for Tourette syndrome is an imbalance in the brain's neurotransmitters, chemicals that transport messages between nerve cells. The main neurotransmitter affected in people with TS is dopamine, which controls movement. Research has shown that two other neurotransmitters, norepinephrine and serotonin, also play a role in the condition. In addition, imaging techniques, such as brain scans, have shown abnormalities in the size and functioning of certain parts of the brain in persons affected by TS.

Symptoms of Tourette syndrome usually appear before the age of 18. Children with TS develop their first tics at the age of six or seven but show other signs of the disorder, including sleep problems, language difficulties, and oppositional behavior, in early childhood, often by the age of two or three. TS usually starts with a single tic, often in the head area (most frequently repeated blinking). The initial tics are generally simple motor tics in the head and upper extremities. As the disorder progresses, the tics gradually move downward to include the torso and lower extremities. Vocal tics usually begin at about the age of nine; complex vocal tics such as coprolalia are among the last to appear. Tics in people with TS are suppressed under certain conditions, usually during sleep and when an individual is engaged in an activity that requires intense concentration. In some cases, children with TS can even manage to keep their tics under control voluntarily in situations where they fear embarrassment, although this takes an immense effort and afterwards the suppressed tics emerge with even greater force than usual. The symptoms of Tourette syndrome increase through childhood and peak during adolescence, after which their intensity usually decreases. An estimated 20-30% of all children with TS outgrow the condition entirely by adulthood.


The Tourette Syndrome Association (TSA) is a national voluntary non-profit membership organization whose mission it is to identify the cause, find the cure for and control the effects of, Tourette Syndrome (TS). TS is a neurological disorder characterized by various motor and vocal tics, ranging from mild to severe. Members of TSA include those with the disorder, their families, and other interested and concerned individuals.

The Tourette Syndrome Association was founded in 1972 in order to disseminate information to interested individuals, health professionals and agencies in the fields of education and government and to coordinate support groups for affected individuals and their families. TSA also funds research to find the cause of TS and its ultimate cure and to find improved medications and treatments. Today its membership includes many thousands of individuals and organizations.

The activities of TSA are diverse, ranging from support and counseling to the publication of educational materials. For instance, TSA offers direct help to families in crisis situations through its National Service Response Team. In addition, the Association maintains a data base of those diagnosed with TS, sponsors a Brain Bank Program for collection of tissue needed for research, and maintains a state-by-state list of doctors who diagnose and treat TS. The Association also represents the interests of members to the government on crucial policy issues.

The Tourette Syndrome Association, Inc. has available an extensive list of publications and video tapes concerning symptoms, diagnosis and treatment options for TS discussed in detail. TSA also publishes a quarterly newsletter outlining the latest treatments, research programs and scientific discoveries.


Although there is no medical cure for Tourette syndrome, medications can relieve many of its symptoms. Currently, the medications of choice for the suppression of tics are antihypertensives, notably Catapres, which reduces tics by 60% in most patients with only minor side effects. Related drugs that have proven effective in tic suppression are Tenex, another antihypertensive, and Klonopin, an antianxiety medication. Another class of drugs, the neuroleptics (including Haldol, Orap, and Prolixin) are even more effective than antihypertensives in suppressing tics, but for most children their advantages are outweighed by side effects, including concentration and memory impairment, weight gain, and drowsiness.

In addition to drugs used for the suppression of tics, additional medications are used to treat other behavioral symptoms associated with Tourette syndrome. Antidepressants such as Prozac and Anafranil are effective in treating obsessive compulsive symptoms, and ADHD is commonly treated with Ritalin or other stimulants. Combining these different types of medications can be a difficult balancing act, and their effects need to be carefully monitored by both parents and physician. For example, the Ritalin used for ADHD may worsen a child's tics, and tricyclic antidepressants such as Norpramin and Anafranil may have to be considered as an alternative treatment for ADHD symptoms. Another symptom of Tourette syndrome that is sometimes treated with medication is uncontrolled aggression, which may be decreased by Tegretol or lithium carbonate. Although medications are universally considered the first line of treatment for Tourette syndrome, relaxation techniques, including self-hypnosis, can also be very helpful in reducing symptoms of the disorder, which worsen with tension. Physical activity is also an excellent way for children with TS to reduce tension and work off their extra energy.

Effects on schoolwork

In spite of the variety of possible symptoms associated with Tourette syndrome, about half of all children who have the disorder require only minor adjustments in order to function successfully in school. The rest require special educational programs to accommodate their needs. TS can disrupt a child's schoolwork in a number of different ways. Tics can make it difficult to concentrate or to perform certain tasks. Ironically, the effort required to suppress them can be just as disruptive because it requires so much energy. Tics can also interfere with the normal school experience by impeding the development of social skills if youngsters feel ostracized by their peers because of their unusual behavior. OCD symptoms also interfere with school performance because preoccupation with obsessive thoughts and the time spent performing compulsive actions make it difficult for children to concentrate on and complete their academic tasks. Children whose TS symptoms include ADHD have trouble with the organizational and concentration skills and the self-control needed for successful performance in school. Fortunately, medication helps alleviate tics and symptoms of OCD and ADHD in many children, giving them a better chance of succeeding in school. However, about 40% of children with Tourette syndrome often have additional learning disabilities that require attention, including problems with reading, math, handwriting, and spelling. In many children with TS, educational problems peak between the ages of 11 and 13 and then gradually decrease in severity. Parents of children with Tourette syndrome whose symptoms interfere with their ability to learn in a regular classroom environment should become familiar with their children's rights to an individualized education program under Public Law 94-142, the 1975 federal law aimed at insuring an adequate education for children with special needs.

Gale Encyclopedia of Childhood & Adolescence. Gale Research, 1998.

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