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Toxocariasis

Toxocariasis is a parasitic infection with the dog or cat roundworm, Toxocara canis or Toxocara cati, respectively. Ingestion of these worms causes the condition, visceral larval migrans. more...

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Epidemiology

Toxocariasis is a worldwide infection. Epidemiologic surveys show a 2-5% positive rate in healthy adults from urban Western countries and 14.2-37% in rural areas. In tropical countries, surveys show a positive rate of 63.2% in Bali, 86% in Saint Lucia, and 92.8% in Réunion. Toxocariasis is most commonly a disease of children, typically children aged 2-7 years.

Pathophysiology

Adult worms of the Toxocara species live in the small intestine of dogs and cats. They range from 4-12 cm in length. Almost all puppies are infected at or soon after birth. During the summer, Toxocara eggs are shed and become infective. They survive for years in the environment, and humans typically ingest the eggs by oral contact with contaminated hands. Once introduced into the human intestine, the eggs hatch, releasing the larvae. The larval form is less than 0.5 mm in length and 0.02 mm wide. The larvae penetrate the bowel wall and migrate through vessels to the muscles, liver, and lung and sometimes to the eye and brain as well.

Disease severity depends not only on the number of larvae ingested but also on the degree of allergic reaction. The inflammatory reaction causes epithelial cells to surround each larva, and, subsequently, a dense fibrous capsule invests each granuloma.

Features

  • Weakness
  • Pruritus
  • Rash
  • Difficulty breathing
  • Abdominal pain
  • Eosinophilia
  • Increased total serum immunoglobulin E (IgE) level
  • Elevated antibody titers to T canis

Diagnosis

In suspected cases, diagnosis is confirmed by an increase in the anti-Toxocara excretory-secretory antigen IgE level

Treatment

Mebendazole or thiobendazole are the treatments of choice.

Prognosis

Toxocariasis is almost always a benign, asymptomatic, and self-limiting disease, although brain involvement can cause brain damage, meningitis, encephalitis, or epilepsy. Ocular involvement may cause loss of visual acuity or unilateral blindness. Pulmonary and hepatic forms can cause protracted symptoms if the patient does not receive treatment.

Prevention

The eggs of Toxocara species are widespread in parks, playgrounds, yards, and in homes and apartments where the occupants have dogs or cats. Elimination of eggs from the environment is not possible; therefore, prevention depends on proper hygiene, including handwashing after contact with pets. Public policies that have attempted to eradicate Toxocara infection in dogs and cats have had limited success.

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Combating infection: How to stop the spread of toxocariasis
From Nursing, 1/1/00 by Caldwell-Blatz, Sally

IN SOME CASES, toxocariasis can cause organ damage and blindness. Because its symptoms mimic many other ailments, identifying toxocariasis tests your assessment skills. Roundworms from the intestines of dogs, possibly cats, and wild animals cause toxocariasis in humans. Learn to identify this infection before it causes serious damage.

Transmission and detection

Almost all puppies are infected with roundworms. Dogs excrete the parasites' eggs in feces, contaminating soil, sandboxes, or even their own fur. People, especially children, can become infected by accidentally ingesting contaminated dirt or sticking contaminated fingers in their mouths. Undercooked game meat is another source of infection.

Once ingested, the eggs hatch into larvae in the small intestine and burrow through body tissue, particularly the heart, lungs, brain, eyes, and muscles, leaving behind inflammation and necrosis. Ocular larva migrans (OLM) involves the eye and can lead to blindness. Visceral larva migrans (VLM), which is more common, involves other tissue. Fortunately, people don't transmit either infection because eggs or larvae aren't expelled in body secretions.

Clinical signs and symptoms vary with the degree of infestation, individual immune response, and the larvae's migration. Some patients are asymptomatic. Those with VLM may have unexplained fever, headache, wheezing, abdominal and leg pain, a creeping poison ivy-like rash, seizures, and Ever enlargement, Signs of OLM include red conjunctiva, impaired vision, and poor eye coordination.

To investigate the possibility of toxocariasis, ask the patient (or his parents) if he has regular contact with dogs or soil. Also, determine if he has a history of eating dirt or other nonfood substances.

Clinicians often diagnose toxocariasis by excluding more common diseases. But the most reliable test is an enzyme-linked immunosorbent assay titer for the Toxocara antigen. Treatment and prevention

Because larvae can live in the body for 10 years or more and no treatment is available to kill them, clinicians treat toxocariasis symptoms with drugs such as albendazole, diethylcarbamazine, and corticosteroids. Infected people aren't tracked consistently, so their prognosis is uncertain.

Help your patients prevent infection by explaining how toxocariasis is transmitted and giving them the following advice:

* Wash hands thoroughly and regularly, especially after contact with soil, sand, or animals.

* Avoid hand-to-mouth contact.

* Deworm dogs 3 weeks after birth and then at least every 2 years, even if stool samples are negative.

* Train pets to defecate on asphalt or another surface that won't contaminate the soil.

* Put wrapped pet feces in the trash.

* Lay plastic on the ground before installing a child's play area.

* Cover sandboxes when not in use so pets don't defecate in them.

BY SALLY CALDWELL-BLATZ RN, BA

Grand Rapids, Ohio

JANICE CHU RN CNS MSN

Clinical Instructor

Mercy College of Nursing, Toledo, Ohio

Copyright Springhouse Corporation Jan 2000
Provided by ProQuest Information and Learning Company. All rights Reserved

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