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Turner's syndrome

Turner syndrome is a human genetic abnormality, caused by a nondisjunction in the sex chromosomes that occurs in females (1 out of every 2,500 births). Instead of the normal XX sex chromosomes, only one X chromosome is present and fully functional; this is called 45,X or X0. In Turner syndrome, female sexual characteristics are present but underdeveloped. more...

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Symptoms

Common symptoms of Turner syndrome include:

  • Short stature
  • Lymphoedema (swelling) of the hands and feet
  • Broad chest and widely-spaced nipples
  • Low hairline
  • Low-set ears
  • Reproductive sterility

Other symptoms include a small lower jaw, cubitus valgus (turned-out elbows), a webbed neck, and soft, upturned nails. Less common are pigmented moles, hearing loss, and a high-arch palate. Turner syndrome manifests itself differently in different people, and no two women need share the same symptoms.

Causes

Turner syndrome is caused by the loss of genetic material from one of the sex chromosomes. In Turner syndrome, the embryo has only one functioning sex chromosome. This chromosome is always an X chromosome, as an embryo with only a Y chromosome is incapable of survival. The remaining X chromosome is either absent or damaged. Mosaic Turner syndrome, where some of the cells have two sex chromosomes but others have only a single functioning X chromosome, is also possible. In cases of mosaic Turner syndrome, the symptoms are usually less pronounced.

There are no known risk factors for Turner syndrome.

Incidence

Approximately 98% of all fetuses with Turner syndrome spontaneously abort. Fetuses with Turner syndrome make up about 10% of the total number of spontaneously aborted fetuses in the United States. The incidence of Turner syndrome in live births is between 1 in 2,500 and 1 in 3,000.

History

The syndrome is named after Henry Turner, an Oklahoma endocrinologist, who described it in the 1940s. In Europe, it is often called Ullrich-Turner syndrome or even Bonnevie-Ulrich-Turner syndrome to acknowledge that earlier cases had also been described by European doctors.

Diagnosis

Turner syndrome may be diagnosed by an amniocentesis during pregnancy. Sometimes, fetuses with Turner syndrome are identified by abnormal ultrasound findings (i.e. heart defect, kidney abnormality, cystic hygroma, ascities). Although the recurrence risk is not increased, genetic counseling is often recommended for families who have had a pregnancy or child with Turner syndrome.

A blood test, called a karyotype, analyzes the chromosomal composition of the individual. This is the most commonly used blood test to diagnose Turner syndrome.

Medical consequences of Turner syndrome

While most of the symptoms of Turner syndrome are harmless, some can lead to significant medical problems.

Cardiovascular

It is interesting for a better understanding to first consider the results of Price et al, 1986 study of 156 female patients with Turner syndrome. Indeed they showed a significantly greater number of deaths from diseases of the circulatory system than expected, half of them due to congenital heart disease. The interesting finding is that when patients with congenital heart disease were omitted from the sample of the study, the mortality from circulatory disorders was not significantly increased.

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Pregnancy Puts Turner's Syndrome Patients at Risk
From OB/GYN News, 5/15/01 by Kate Johnson

TORONTO -- Egg donation has opened the door to the possibility of pregnancy in women with Turner's syndrome, but it also exposes them to some unexpected and possibly fatal cardiac risks.

"Few elective treatments in medicine today place seemingly healthy patients at risk of death. But in reproductive medicine, by allowing Turner's syndrome patients to achieve pregnancy through oocyte donation, we may be doing just that," Dr. Megan Karnis said at the annual meeting of the Society for Gynecologic Investigation.

Turner's syndrome, which affects women only, is caused by the complete or partial absence of one of the X chromosomes. Affected women experience a premature loss of oocytes, which usually results in infertility, explained Dr. Richard Reindollar, director of reproductive endocrinology at the Beth Israel Deaconess Medical Center, Boston.

"Only about 15% of patients have enough oocytes to go through puberty, and about 5% develop menstrual cyclicity, which usually stops in their 20s. About 1% of patients can achieve a spontaneous pregnancy, but there is a high miscarriage rate," he explained.

As a result, obstetricians rarely see pregnant women with Turner's syndrome and have little knowledge of their condition, which is also characterized by a high rate of cardiac abnormalities.

"It is estimated that 20%-30% of patients with Turner's syndrome have some associated cardiac malformation, although some studies suggest that the most common problem, which is bicuspid aortic valve, may actually occur in up to 50% of patients," said Dr. Karnis, a clinical fellow in obstetrics, gynecology, and reproductive endocrinology at Beth Israel Deaconess.

In addition, mitral valve prolapse occurs in about 25% of patients, and aortic dilation occurs in 5%. Ten percent of cardiac fatalities in Turner's syndrome patients occur in the absence of known risk factors.

The literature contains reports on at least 68 patients with Turner's syndrome who have died from aortic rupture or aortic dissection when they weren't pregnant.

"We are concerned that the increased cardiovascular demands of pregnancy might increase this risk and may not be safe for women with Turner's," Dr. Reindollar said.

In a survey of all 259 donor oocyte programs listed in the 1997 Society for Assisted Reproductive Technology report, Dr. Karnis and Dr. Reindollar found that less than 50% of patients with Turner's syndrome had been given cardiac screening before entering treatment.

Among the 123 programs that responded to the survey, 143 patients with Turner's syndrome had received donor oocytes, but only 71 (50%) of these patients had been given screening echocardiography, they reported.

Abnormal cardiac findings were reported in 6 of these 71 patients (8.4%), four of whom had aortic abnormalities. One of the six also had aortic dilatation, a bicuspid aortic valve, and aortic regurgitation.

Pregnancy was achieved in 99 patients, for a crude pregnancy rate of 60.9%, and 17 patients had multiple-gestation pregnancies.

One death, from an aortic rupture, was reported in a woman with Turner's syndrome who was awaiting donor oocyte treatment.

Dr. Karnis said that the incidence of pregnancy-related cardiac deaths is probably higher than the study showed.

"We know that in the literature, there have been two or three reported deaths during pregnancy in Turner's syndrome patients who have received donor oocytes. These deaths were not reported to us in the survey, so they must have occurred in the 53% of clinics that have not yet responded to us," she explained.

Dr. Karnis and Dr. Reindollar recommended that more thorough echocardiographic screening be done for patients with Turner's syndrome who wish to receive donated oocytes and that patients be carefully counseled about the risks they may be undertaking before attempting to get pregnant.

"Both physicians and patients should at least be cognizant of these risks and that these problems can occur even in patients with no identifiable risk factors," Dr. Reindollar said.

If the patient decides to take the risk, Dr. Reindollar recommends regular echocardiography, probably in every trimester.

"Many if not most women with Turner's syndrome who have died from spontaneous dissection and rupture have gone to the ER with a complaint and have been sent home with a misdiagnosis to die at home. These patients need to be aware that if they have any unusual symptoms that take them to the emergency room, even if they have negative screens, they should at least let the healthcare providers know what their risks are, and what to look for," he said.

COPYRIGHT 2001 International Medical News Group
COPYRIGHT 2001 Gale Group

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