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Asbestosis

Asbestosis is a chronic inflammatory medical condition affecting the parenchymal tissue of the lungs. It occurs after long-term, heavy exposure to asbestos, e.g. in mining. Sufferers have severe dyspnea (shortness of breath) and are at an increased risk regarding several different types of lung cancer. more...

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As clear explanations are not always stressed in non-technical literature, care should be taken to distinguish between several forms of relevant diseases. According to the World Health Organisation (WHO), these may defined as; asbestosis (the subject of this article), lung cancer, and mesothelioma (generally a very rare form of cancer, when more widespread it is almost always associated with prolonged exposure to asbestos).

Signs and symptoms

The primary symptom of asbestosis is generally the slow, insidious onset of shortness of breath on exertion. In severe, advanced cases, this may lead to respiratory failure. Coughing is not usually a typical symptom, unless the patient has other, concomitant respiratory tract diseases.

People with extensive occupational exposure to the mining, manufacturing, handling or removal of asbestos are at risk of developing asbestosis. There is also an increased risk of lung cancer and mesothelioma. This risk is related to the total dose of asbestos received and the duration of asbestos exposure.

Diagnosis

The definitive diagnosis of asbestosis is largely dependent on a detailed and accurate clinical history. Reliable data on the level and duration of occupational exposure to asbestos is critical to the diagnosis (though, until recently, rarely available in practice). Histopathological diagnosis is usually not necessary for patient management but can be used to confirm the diagnosis, especially if the simultaneous presence of other diseases is suspected.

Pathogenesis

Asbestosis is the scarring of lung tissue resulting from the inhalation of asbestos fibers. When such fibers reach the alveoli (air sacs) in the lung, where oxygen is transferred into the blood, the foreign bodies (asbestos fibers) activate the lung's local immune system and provoke an inflammatory reaction. Macrophages phagocytose (ingest) the fibers and stimulate fibroblasts to deposit connective tissue. The result is fibrosis. The fibrotic scar tissue is much less efficient in gas exchange, reducing oxygen transfer to the blood, as well as the removal of carbon dioxide. The total lung capacity (TLC) may be reduced. In the more severe cases, the drastic reduction in lung function may induce heart failure (cor pulmonale).

Treatment

There is no curative treatment. Close monitoring (routine X-rays or even pleural biopsy) for mesothelioma is mandated. Oxygen therapy at home is often necessary to relieve the shortness of breath. Supportive treatment of symptoms includes respiratory treatments to remove secretions from the lungs by postural drainage, chest percussion, and vibration. Aerosol medications to thin secretions may be prescribed.

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Why did the barber acquire asbestosis?
From CHEST, 4/1/04 by John P.V. Rigby

To the Editor:

The index case had worked from 1964 to 1993 as maintenance fitter in an asbestos factory. He dusted down machines, repaired them, and swept up afterwards. He worked all over the factory, "Asbestos dust lay thick everywhere" was his comment. Danger from asbestos produced no concern to the 1960s, in that no factory precautions were taken. Thus, no masks or caps were worn, machines were not washed down, and there were no extractor fans. There was asbestos laden white dust outside the showers and changing reruns. A shower would be like "taking a dust bath," he said. Following legislation in the early 1970s, working conditions at the factory had improved, and the firm began phasing out asbestos products. The fitter was then provided with a cap and mask, but recalls no warning being given to avoid contamination with any dust about the factory, and no one was told that the dust was dangerous. In May 1993, he became ill and has not worked since then. Symptoms and findings confirmed the diagnosis of asbestosis, following employment in the asbestos factory from 1964 to 1993, and he began drawing compensation backdated to 1987.

The special interest arises out of people who were not employed at the factory but who had contact with the index case and coworkers. The fitter took his overalls home, where his daughter shook them free from dust and laundered them. Twenty years later, she was said to have been found to have pleural plaques, presumed related to asbestos exposure. He knew of several men at the factory whose wives had laundered their overalls at home anti had had "chest trouble," but he knew no details.

However, the indirect exposure associated with the most serious consequence related to the barber. Men from the factory often went to the village barber during the lunch break, for a haircut. The barber had worked over forty years locally until retirement in 1987 at the age of 63 years. An account from his assistant employed for his final 18 years said, "The men write often covered with dust, you combed it out of their hair, you worked at hair level, and shook the cloth afterwards." At no time had the barber worked inside the asbestos factory premises, and (as far as could be determined) any asbestos exposure arose only in his barber shop. He died in hospital in 1992 of pneumonia and mesothelioma (of the left lung), which the coroner decided was asbestos related. The case illustrates the potential for serious asbestos exposure in people (such as the barber) closely associated with workers who were themselves exposed when control measures and risk awareness were largely nonexistent.

John P. V. Rigby, BM

Guy's Hospital

London, UK

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (e-mail: permissions@chestnet.org).

Correspondence to: John P. V. Rigby BM, Huntsmoor Weir, Old Mill Lane, Cowley, Uxbridge, United Kingdom UB8 2JH

COPYRIGHT 2004 American College of Chest Physicians
COPYRIGHT 2004 Gale Group

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