Levothyroxine chemical structure
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Levoxyl


Levothyroxine, also known as L-thyroxine, synthetic T4 or simply 3,5,3',5'-tetraiodo-L-thyronine, is a synthetic form of thyroxine (thyroid hormone). As the hormone is chemically in the L-form (instead of D, see chirality), it is metabolised much slower than physiological thyroid hormone, which has a shorter half-life. more...

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The EU has recently standardised the use of the name "levothyroxine" for the drug. Common brand names include "Thyrax", "Euthyrox", "Levaxin" and "Eltroxin" in Europe, and "Levoxyl" and "Synthroid" in the US.

This medicine is usually given to patients with thyroid problems. These many problems can affect the patient's (if he/she is a child/teenager) growth and/or weight.

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Mylan Laboratories
From Drug Store News, 11/22/04

Mylan Laboratories stated it would not be put off by its largest shareholder, Carl Icahn, who filed a letter with the Securities and Exchange Commission on Nov. 1, denouncing Mylan's effort to acquire King Pharmaceuticals. King's third quarter earnings showed a 74 percent drop in profits and a high level of product returns that could force the company to restate its earnings for the year. The Wall Street Journal reported that Icahn owns 26.2 million shares, or 9.8 percent of the company, worth more than $459 million.

Icahn has criticized the King deal, valued at about $4 billion, saying it's too expensive and too risky. Icahn also has commissioned a consulting firm to conduct a study evaluating the generics industry, which is expected to be released shortly. In a statement issued by Mylan, Chief Executive Officer Robert Coury noted, "Mylan's board of directors and management will continue to be thorough in their analysis of King and its recent disclosures and will neither be distracted nor deterred by Mr. Icahn."

King makes the branded drugs Altace for the treatment of high blood pressure and Levoxyl for hypothyroidism.

In other news, Mylan was granted tentative approval for its ANDA for pioglitazone HC1 tablets in 15 mg, 30mg and 45 mg dosages. Pioglitazone HC1 tablets are the generic version of Takeda Pharmaceuticals' Actos tablets, taken once a day to help lower blood glucose levels in people with Type 2 diabetes. Actos is co-promoted by Takeda Pharmaceuticals North America and Eli Lilly.

COPYRIGHT 2004 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2004 Gale Group

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