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Activated protein C resistance

Activated protein C resistance is a hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). This results in an increased risk of venous thrombosis. more...

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Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave factors V and/or VIII. This may be hereditary or acquired. The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.

In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)). It has been estimated that up to 64% of patients with venous thromboembolism might have activated protein C resistance.

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Role of activated protein C in the pathophysiology of severe sepsis - CE Article
Sepsis is a complex syndrome that can lead to multiple organ failure and death. Severe sepsis has been associated with mortality rates ranging from 28% to 50% and is the most common cause of death
Functional activated protein C resistance assays: Correlation with factor V DNA analysis is better with RVVT-than APTT-based assays
Abstract: We compare results of factor V DNA analysis with three different clotting-based assays designed to detect activated protein C (APC) resistance ...
Testing for resistance to activated protein C factor V R506Q / In reply
To the Editor.-In their article, Montes et al1 reported that the cost per test for materials to perform functional screening for activated protein C resistance ...
Activated protein C resistance assay performance: Improvement by sample dilution with factor V-deficient plasma
Objectives.-To evaluate a modification of a commercially available reagent kit (COATEST APC Resistance Kit) for functional activated protein C (APC) resistance testing, and to determine the ability
Comparison of functional testing for resistance to activated protein C and molecular biological testing for factor V R506Q in 370 patients
Objective.-To compare functional and molecular biological tests for resistance to activated protein C (APC)/ factor V R506Q, the most common cause of ...
Activated protein C resistence, the factor V leiden mutation, and a laboratory testing algorithm
Objectives.-To present the current understanding of factor V Leiden and activated protein C resistance, and to propose a laboratory testing algorithm.
The renaissance of C reactive protein: it may be a marker not only of acute illness but also of future cardiovascular disease - Editorial
Elevated blood levels of C-reactive protein (CRP) may be a risk factor for cardiovascular disease. CRP has traditionally been used as a marker of tissue ...
Hereditary deficiencies of antithrombin III, protein S, and the protein C pathway in Jordanian thrombosis patients
Hereditary thrombophilia is caused by various inherited disorders. Most lead to a familial tendency to recurrent venous, not arterial, thrombosis, usually ...

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