Supercentenarian Ann Pouder (8 April 1807 – 10 July 1917) photographed on her 110th birthday. A heavily lined face is common in human senescence.Old Klamath woman by Edward S. Curtis, 1924
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Senescence

In biology, senescence is the combination of processes of deterioration which follow the period of development of an organism. For the science of the care of the elderly, see gerontology; for experimental gerontology, see life extension. The word senescence is derived from the Latin word senex, meaning "old man" or "old age." more...

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Cellular senescence is the phenomenon where cells lose the ability to divide. In response to DNA damage (including shortened telomeres) cells either senesce or self-destruct (apoptosis) if the damage cannot be repaired. Organismal senescence is the aging of whole organisms. The term aging has become so commonly equated with senescence that the terms will be used interchangeably in this article.

Aging is generally characterized by the declining ability to respond to stress, increasing homeostatic imbalance and increased risk of disease. Because of this, death is the ultimate consequence of aging. Differences in maximum life span between species correspond to different "rates of aging". For example, inheritance make a mouse elderly at 3 years and a human elderly at 90 years. These genetic differences relate to the efficiency of DNA repair, antioxidant enzymes, rates of free radical production, etc.

Some researchers in gerontology (specifically biogerontologists) regard aging itself as a "disease" that may be curable, although this view is controversial. To those who accept the view, aging is an accumulation of damage to macromolecules, cells, tissues and organs. Advanced biochemical and molecular repair technologies may be able to fix the damage we call aging (thereby curing the disease and greatly extending maximum lifespan). People who hope to wish to extend human maximum life span through science are called life extensionists.

Genetic and environmental interventions are known to affect the life span of model organisms. This gives many hope that human aging can be slowed, halted, or reversed. Dietary calorie restriction, by 30 percent for example, extends the life span of yeast, worms, flies, mice, and monkeys. Several genes are known to be necessary for this extension, and modification of these genes is also sufficient to produce the same effect as diet.

Resveratrol, a polyphenol found in the skin of red grapes, was reported to extend the lifespan of yeast, worms, and flies, although this data has since been disproven in yeast and has yet to be verified in flies.

Theories of aging

The process of senescence is complex, and may derive from a variety of different mechanisms and exist for a variety of different reasons. However, senescence is not universal, and scientific evidence suggests that cellular senescence evolved in certain species as a mechanism to prevent the onset of cancer. In a few simple species, senescence is negligible and cannot be detected. All such species have no "post-mitotic" cells; they reduce the effect of damaging free radicals by cell division and dilution. Such species are not immortal, however, as they will eventually fall prey to trauma or disease. Moreover, average lifespans can vary greatly within and between species. This suggests that both genetic and environmental factors contribute to aging.

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Developmental Biology of Neoplastic Growth (Progress in Molecular and Subcellular Biology) $95.00 Masturbation: From Infancy to Senescence $4.10
Strategies For Engineered Negligible Senescence: Why Genuine Control Of Aging May Be Foreseeable (Annals of the New York Academy of Sciences, V. 1019) $124.99

Size specific fecundity of red abalone : evidence for reproductive senescence?
ABSTRACT The fecundity of wild red abalone. Haliotis rufescens, was examined during four reproductive seasons (2000-2003) in northern California. A broad size range of abalone were sampled (n = 425
Role of intraspecific competition in mass seeding and senescence in Polymnia canadensis, a primarily monocarpic species4
MARTIN H. BENDER1, JERRY M. BASKIN1, AND CAROL C. BASKIN1,2 (1School of Biological Sciences, University of Kentucky, Lexington KY 40506-0225, 2Department ...
A biologically based model of growth and senescence of Syrian Hamster Embryo cells after exposure to arsenic - SHE - Articles
We modified the two-stage Moolgavkar-Venzon-Knudson (MVK) model for use with Syrian hamster embryo (SHE) cell neoplastic progression. Five phenotypic ...
The Extent Of The P16 Pathway In Breast Cancer And Senescence Control
THE EXTENT OF THE P16 PATHWAY IN BREAST CANCER AND SENESCENCE CONTROL.
Identification And Localization Of Genes That Restore Senescence In Breast Cancer Cells
Using a combination of positional and functional cloning, this (Temple University) work maps SEN 16 to a l00xb region at 16q24.3. Intact normal human ...
Effects of Yukmi, an Herbal Formula, on the Liver of Senescence Accelerated Mice Exposed to Oxidative Stress - SAM
Abstract: The effects of Yukmi (Decoction of six plants including rehmannia), an herbal formula, were studied on liver oxidant damage induced by paraquat ...
Individual Differences, Longevity, And Reproductive Senescence In Bighorn Ewes
MARCO FESTA-BIANCHET, [1] CELINE H. BERUBE, [1,3] JON T. JORGENSON [2] (1.) Groupe de recherche en ecologie, nutrition et energetique, Departement ...
Age-Specific Survival In Five Populations Of Ungulates: Evidence Of Senescence
MARCO FESTA-BIANCHET, [2] JEAN-MICHEL GAILLARD, [3] JON T. JORGENSON, [4] JEAN-MICHEL JULLIEN [5] ANNE LOISON, [1,6] (1.) Norwegian Institute ...

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