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Acute renal failure

Acute renal failure (ARF) is a rapid loss of renal function due to damage to the kidneys, resulting in retention of nitrogenous (urea and creatinine) and non-nitrogenous waste products that are normally excreted by the kidney. Depending on the severity and duration of the renal dysfunction, this accumulation is accompanied by metabolic disturbances, such as metabolic acidosis (acidification of the blood) and hyperkalaemia (elevated potassium levels), changes in body fluid balance, and effects on many other organ systems. more...

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It can be characterised by oliguria or anuria (decrease or cessation of urine production), although nonoliguric ARF may occur. It is a serious disease and treated as a medical emergency.

Causes

Renal failure, whether chronic or acute, is usually categorised according to pre-renal, renal and post-renal causes:

  • Pre-renal (causes in the blood supply):
    • hypotension (decreased blood supply), usually from shock or dehydration and fluid loss, heart attack
    • vascular problems, such as atheroembolic disease and renal vein thrombosis (which in part may be secondary to loss of coagulation factors due to renal dysfunction)
  • Renal (damage to the kidney itself):
    • infection
    • toxins or medication (e.g. some NSAIDs, aminoglycoside antibiotics, amphotericin B, iodinated contrast, lithium)
    • rhabdomyolysis (breakdown of muscle tissue) - the resultant release of myoglobin in the blood affects the kidney; it can be caused by injury (especially crush injury and extensive blunt trauma), statins, MDMA (ecstasy) and some other drugs
    • hemolysis (breakdown of red blood cells) - the hemoglobin damages the tubules; it may be caused by various conditions such as sickle-cell disease, and lupus erythematosus
    • multiple myeloma, either due to hypercalcemia or "cast nephropathy" (multiple myeloma can also cause chronic renal failure by a different mechanism)
    • Acute glomerulonephritis which may due to a variety of causes, such as anti glomerular basement membrane disease/Goodpasture's syndrome, Wegener's granulomatosis or acute lupus nephritis with systemic lupus erythematosus
  • Post-renal (causes in the urinary tract):
    • urinary retention (as a side-effect of medication or due to benign prostatic hypertrophy, kidney stones)
    • pyelonephritis
    • obstruction due to abdominal malignancy (e.g. ovarian cancer, colorectal cancer)

Diagnosis

Renal failure is generally diagnosed either when creatinine or blood urea nitrogen tests are markedly elevated in an ill patient, especially when oliguria is present. Previous measurements of renal function may offer comparison, which is especially important if a patient is known to have chronic renal failure as well. If the cause is not apparent, a large amount of blood tests and examination of a urine specimen is typically performed to elucidate the cause of acute renal failure, medical ultrasonography of the renal tract is essential to rule out obstruction of the urinary tract.

Consensus criteria for the diagnosis of ARF are:

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Are diuretics helpful in acute renal failure? - Patient Oriented Evidence that Matters
From Journal of Family Practice, 3/1/03 by Lawrence Dybedock

Mehta LM, Pascual MT, Soroko S, Chertow GM. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 2002; 288:2547-2553.

* PRACTICE RECOMMENDATIONS

Although widely used to treat acute renal failure, diuretics may actually be harmful.

The results of this observational study demonstrated a higher risk of death and nonrecovery of renal function when diuretics were initiated during the first week of hospitalization. It didn't matter whether a single or combination diuretic was used.

A randomized controlled trial would better answer this question by minimizing the inherent flaws in an observational study. Although this study doesn't conclusively prove that diuretics cause poorer outcomes, it certainly raises the possibility and should prompt us to think twice before initiating diuretic therapy for acute renal failure.

* BACKGROUND

Diuretics continue to be widely used for treating acute renal failure despite the lack of supporting evidence. The ability to promote renal salt and water excretion with diuretics and extracellular volume overload in patients with acute renal failure influences the decision of many practitioners to use these medications.

This study evaluated the effects of diuretics on mortality, renal function, and length of hospital stay in hospitalized patients with acute renal failure.

* POPULATION STUDIED

The authors studied 552 critically ill patients with acute renal failure in 4 California academic medical center ICUs. In patients without previous kidney disease, acute renal failure was defined as blood urea nitrogen >40 mg/dL or creatinine >2 mg/dL. In others, acute renal failure was defined as creatinine levels rising at >1 mg/dL compared with baseline. Patients were excluded if they had previous dialysis, urinary tract obstruction, or hypovolemia.

* STUDY DESIGN AND VALIDITY

Patients in this prospective cohort study were placed into groups according to which day diuretics were initiated during the first week following consultation. Patients were also categorized as "ever" or "never" having received diuretics. Patients received 1 or more of the following: furosemide, bumetanide, metolazone, and hydrochlorothiazide.

The researchers monitored vital signs, urine output, blood urea nitrogen, and serum creatinine levels each day until hospital discharge. They calculated disease-specific severity-of-illness scores daily in the ICU based on the number of organ systems in failure.

Because these patient groups were given therapies not randomly assigned, the researchers adjusted for confounding variables with regression methods based on propensity scores of illness severity.

The study design used in this research limits our ability to draw conclusions regarding any true causal relationship between diuretic use and poorer outcomes. A randomized controlled trial is needed to definitively establish cause and effect.

Also, the results from this study of critically ill patients cannot be generalized to patients with less severe forms of acute renal failure. The results may not apply to patients in other medical institutions where management of acute renal failure and availability of dialysis differs.

* OUTCOMES MEASURED

The primary outcomes were mortality, nonrecovery of renal function, and length of hospital stay.

* RESULTS

Of the 552 patients included in the final sample, 294 (53%) died in the hospital. 0f the 258 patients who survived, 17 required dialysis following discharge. Diuretics were used in 326 patients (59%).

Based on adjusted models, the use of diuretics was associated with a 68% increase in mortality (odds ratio [OR]=1.68: 95% confidence interval [CI], 1.06-2.64) and a 79% increase in the nonrecovery of renal function (OR=1.79; 95% CI, 1.19-2.68). Length of stay was not affected if diuretics were started on the first day of consultation (median 21.5 vs 22.5 days). However, diuretics initiated any other day during the first week prolonged hospital stays by a median of 4 to 10 days.

Patients who received diuretics at any time during that week had higher risk of death or nonrecovered renal function compared to patients who never received a diuretic (OR=3.12; 95% CI, 1.73-5.62). Patients with low urine output despite higher-dose diuretics died or needed dialysis sooner than patients who became nonoliguric with lower-dose diuretics. No significant differences in mortality, nonrecovery of renal function, and length of hospital stay occurred when comparing patients receiving combination diuretics vs single diuretics.

Lawrence Dybedock, MD, and Kevin Kane, MD, MSPH, Department of Family & Community Medicine, University of Missouri, Columbia. E-mail: dybedockl@health.missouri.edu.

COPYRIGHT 2003 Dowden Health Media, Inc.
COPYRIGHT 2003 Gale Group

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