Find information on thousands of medical conditions and prescription drugs.

Acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS), also known as respiratory distress syndrome (RDS) or adult respiratory distress syndrome (in contrast with IRDS) is a serious reaction to various forms of injuries to the lung. This is the most important disorder resulting in increased permeability pulmonary edema. more...

Home
Diseases
A
Aagenaes syndrome
Aarskog Ose Pande syndrome
Aarskog syndrome
Aase Smith syndrome
Aase syndrome
ABCD syndrome
Abdallat Davis Farrage...
Abdominal aortic aneurysm
Abdominal cystic...
Abdominal defects
Ablutophobia
Absence of Gluteal muscle
Acalvaria
Acanthocheilonemiasis
Acanthocytosis
Acarophobia
Acatalasemia
Accessory pancreas
Achalasia
Achard syndrome
Achard-Thiers syndrome
Acheiropodia
Achondrogenesis
Achondrogenesis type 1A
Achondrogenesis type 1B
Achondroplasia
Achondroplastic dwarfism
Achromatopsia
Acid maltase deficiency
Ackerman syndrome
Acne
Acne rosacea
Acoustic neuroma
Acquired ichthyosis
Acquired syphilis
Acrofacial dysostosis,...
Acromegaly
Acrophobia
Acrospiroma
Actinomycosis
Activated protein C...
Acute febrile...
Acute intermittent porphyria
Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Acute mountain sickness
Acute myelocytic leukemia
Acute myelogenous leukemia
Acute necrotizing...
Acute promyelocytic leukemia
Acute renal failure
Acute respiratory...
Acute tubular necrosis
Adams Nance syndrome
Adams-Oliver syndrome
Addison's disease
Adducted thumb syndrome...
Adenoid cystic carcinoma
Adenoma
Adenomyosis
Adenosine deaminase...
Adenosine monophosphate...
Adie syndrome
Adrenal incidentaloma
Adrenal insufficiency
Adrenocortical carcinoma
Adrenogenital syndrome
Adrenoleukodystrophy
Aerophobia
Agoraphobia
Agrizoophobia
Agyrophobia
Aicardi syndrome
Aichmophobia
AIDS
AIDS Dementia Complex
Ainhum
Albinism
Albright's hereditary...
Albuminurophobia
Alcaptonuria
Alcohol fetopathy
Alcoholic hepatitis
Alcoholic liver cirrhosis
Alektorophobia
Alexander disease
Alien hand syndrome
Alkaptonuria
Alliumphobia
Alopecia
Alopecia areata
Alopecia totalis
Alopecia universalis
Alpers disease
Alpha 1-antitrypsin...
Alpha-mannosidosis
Alport syndrome
Alternating hemiplegia
Alzheimer's disease
Amaurosis
Amblyopia
Ambras syndrome
Amelogenesis imperfecta
Amenorrhea
American trypanosomiasis
Amoebiasis
Amyloidosis
Amyotrophic lateral...
Anaphylaxis
Androgen insensitivity...
Anemia
Anemia, Diamond-Blackfan
Anemia, Pernicious
Anemia, Sideroblastic
Anemophobia
Anencephaly
Aneurysm
Aneurysm
Aneurysm of sinus of...
Angelman syndrome
Anguillulosis
Aniridia
Anisakiasis
Ankylosing spondylitis
Ankylostomiasis
Annular pancreas
Anorchidism
Anorexia nervosa
Anosmia
Anotia
Anthophobia
Anthrax disease
Antiphospholipid syndrome
Antisocial personality...
Antithrombin deficiency,...
Anton's syndrome
Aortic aneurysm
Aortic coarctation
Aortic dissection
Aortic valve stenosis
Apert syndrome
Aphthous stomatitis
Apiphobia
Aplastic anemia
Appendicitis
Apraxia
Arachnoiditis
Argininosuccinate...
Argininosuccinic aciduria
Argyria
Arnold-Chiari malformation
Arrhythmogenic right...
Arteriovenous malformation
Arteritis
Arthritis
Arthritis, Juvenile
Arthrogryposis
Arthrogryposis multiplex...
Asbestosis
Ascariasis
Aseptic meningitis
Asherman's syndrome
Aspartylglycosaminuria
Aspergillosis
Asphyxia neonatorum
Asthenia
Asthenia
Asthenophobia
Asthma
Astrocytoma
Ataxia telangiectasia
Atelectasis
Atelosteogenesis, type II
Atherosclerosis
Athetosis
Atopic Dermatitis
Atrial septal defect
Atrioventricular septal...
Atrophy
Attention Deficit...
Autoimmune hepatitis
Autoimmune...
Automysophobia
Autonomic dysfunction
Familial Alzheimer disease
Senescence
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

ARDS is a severe lung disease caused by a variety of direct and indirect insults. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure. This condition is life threatening and often lethal. So it usually requires mechanical ventilation and admission to an intensive care unit. A less severe form is called acute lung injury (ALI).

ARDS formerly most commonly signified adult respiratory distress syndrome to differentiate it from infant respiratory distress syndrome in premature infants. However, as this type of pulmonary edema also occurs in children, ARDS has gradually shifted to mean acute rather than adult. The differences with the typical infant syndrome remain.

Definition

Historical background

Acute respiratory distress syndrome was first described in 1967 by Ashbaugh et al. Initially there was no definition, resulting in controversy over incidence and mortality. In 1988 an expanded definition was proposed which quantified physiologic respiratory impairment.

In 1994 a new definition was recommended by the American-European Consensus Conference Committee. It had two advantages: 1 it recognizes that severity of pulmonary injury varies, 2 it is simple to use..

ARDS was defined as the ratio of arterial partial oxygen tension (PaO2) as fraction of inspired oxygen (FiO2) below 200 mmHg in the presence of bilateral alveolar infiltrates on the chest x-ray. These infiltrates may appear similar to those of left ventricular failure, but the cardiac silhouette appears normal in ARDS. Also, the pulmonary capillary wedge pressure is normal (less than 18 mmHg) in ARDS, but raised in left ventricular failure.

A PaO2/FiO2 ratio less than 300 mmHg with bilateral infiltrates indicates acute lung injury (ALI). Although formally considered different from ARDS, ALI is usually just a precursor to ARDS.

Consensus after 1967 and 1994

ARDS is characterized by:

  • Acute onset
  • Bilateral infiltrates on chest radiograph
  • Pulmonary artery wedge pressure < 18 mmHg (obtained by pulmonary artery catheterization)
  • if PaO2:FiO2 < 300 acute lung injury (ALI) is considered to be present
  • if PaO2:FiO2 < 200 acute respiratory distress syndrome (ARDS) is considered to be present

Read more at Wikipedia.org


[List your site here Free!]


Quetiapine overdose induced acute respiratory distress syndrome
From CHEST, 10/1/05 by Paul Strachan

INTRODUCTION: A 41 year-old male, with bipolar disorder presented after ingestion of 4500 mg of quetiapine. Within 24 hours, respiratory failure ensued, requiring intubation and mechanical ventilation. Chest radiograph demonstrated bilateral infiltrates, consistent with Acute Respiratory Distress Syndrome (ARDS).

CASE PRESENTATION: The patient is a 41-year old male with a history of bipolar disorder and generalized anxiety. He was recently admitted to another hospital with depression and suicidal ideation. Discharge medications included: quetiapine 25 mg twice daily, valproic acid, gabapentin, desipramine and paroxetine. Two days post-discharge, his parents observed clonic movements that were presumed to be seizures. Intravenous lorazepam was administered by EMS with no response. A suicide note was found next to an empty bottle of quetiapine that previously contained 180, 25 mg tablets. On examination: Vitals: HR 98, RR 20, BP 100/60, T 97.2 F. 02 Sat 100%. HEENT: Minimally reactive pupils, bilateral opsoclonus. Lungs: Poor inspiratory effort, otherwise clear. Heart: Regular rate & rhythm. Abdominal: Normal active bowel sounds, soft, non-tender. Extremities: No edema, clubbing or cyanosis. Neurological: Drowsy, but arousable to stimuli. Glasgow Coma Scale = 8. Frequent myncolonic jerks in all extremities. Chest radiograph: Minimally increased interstitial markings (Fig 1). ECG: Sinus Rhythm at 98 bpm. QT/QTc interval was prolonged at 536/684. EEG: No epileptiform activity. Toxicology: Positive for tricyclic antidepressants (TCA). Gas chromatography showed desipramine and quetiapine (quantitative levels were not available). Valproic acid level: 22 (ref 50-120). He received intravenous lorazepam, magnesium and sodium bicarbonate for electrocardiographic changes and was admitted to the intensive care unit (ICU). During the first twenty-four hours, the patient developed progressive hypoxemia, unresponsive to increased oxygen supplementation. There was no witnessed aspiration. He was intubated for hypoxemic respiratory failure. Post-intubation, he required 100% FIO2 and high levels of positive end-expiratory pressure (PEEP). Chest radiograph showed bilateral infiltrates (Fig 2). Central venous pressure (CVP) measured 10 cmH2O. Echocardiogram showed normal left ventricular function. The patient had a prolonged ICU course, complicated by the subsequent development of gram-negative bacteremia. After five weeks of mechanical ventilation, he improved clinically and was extubated. Once stable, he was transferred to psychiatry for further care.

[FIGURES 1-2 OMITTED]

DISCUSSIONS: Quetiapine fumarate is an antipsychotic drug that is an antagonist at multiple receptors in the brain including: serotonin, dopamine, adrenergic and histamine. Compared to older antipsychotic medications, it has an improved safety profile, particularly decreased extrapyramidal symptoms and tardive dyskinesia, although there is still a risk for neuroleptic malignant syndrome. (1) This patient developed progressive hypoxia with infiltrates, requiring mechanical ventilation within 24 hours of presentation. Respiratory depression has previously been seen with large ingestions of quetiapine. In a case series by Balit, four of eighteen patients with quetiapine overdose required mechanical ventilation. No patients developed ARDS. Our patient presented with minimal changes on his initial chest x-ray. Within 24 hours he had bilateral infiltrates and was intubated for respiratory failure. He required 100% FIO2 while on the ventilator, with an initial PaO2:FIO2 ratio of 90. The CVP was 10 mmHg and the ejection fraction was normal. These findings are all consistent with the diagnosis of ARDS. This is the first reported case of such resulting from quetiapine overdose.

CONCLUSION: As quetiapine is a relatively new medication, experience with cases of overdose are limited. This patient's respiratory status rapidly declined over the first twenty-four hours. Cases involving quetiapine overdose warrant admission, with close monitoring of respiratory status.

REFERENCE:

(1) Mosbey Drug Consult 2004 2 Balit C. et al. Quetiapine Poisoning: A Case Series. 2003 Annals of Emergency Medicine 42:6 751-758

DISCLOSURE: Paul Strachan, None.

Paul Strachan MD * Brian Benoff MD Long Island Jewish Medical Center, New Hyde Park, NY

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

Return to Acute respiratory distress syndrome
Home Contact Resources Exchange Links ebay