Find information on thousands of medical conditions and prescription drugs.

Aortic coarctation

Aortic coarctation is narrowing of the aorta in the area where the ductus arteriosus (ligamentum arteriosum after regression) inserts. more...

Home
Diseases
A
Aagenaes syndrome
Aarskog Ose Pande syndrome
Aarskog syndrome
Aase Smith syndrome
Aase syndrome
ABCD syndrome
Abdallat Davis Farrage...
Abdominal aortic aneurysm
Abdominal cystic...
Abdominal defects
Ablutophobia
Absence of Gluteal muscle
Acalvaria
Acanthocheilonemiasis
Acanthocytosis
Acarophobia
Acatalasemia
Accessory pancreas
Achalasia
Achard syndrome
Achard-Thiers syndrome
Acheiropodia
Achondrogenesis
Achondrogenesis type 1A
Achondrogenesis type 1B
Achondroplasia
Achondroplastic dwarfism
Achromatopsia
Acid maltase deficiency
Ackerman syndrome
Acne
Acne rosacea
Acoustic neuroma
Acquired ichthyosis
Acquired syphilis
Acrofacial dysostosis,...
Acromegaly
Acrophobia
Acrospiroma
Actinomycosis
Activated protein C...
Acute febrile...
Acute intermittent porphyria
Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Acute mountain sickness
Acute myelocytic leukemia
Acute myelogenous leukemia
Acute necrotizing...
Acute promyelocytic leukemia
Acute renal failure
Acute respiratory...
Acute tubular necrosis
Adams Nance syndrome
Adams-Oliver syndrome
Addison's disease
Adducted thumb syndrome...
Adenoid cystic carcinoma
Adenoma
Adenomyosis
Adenosine deaminase...
Adenosine monophosphate...
Adie syndrome
Adrenal incidentaloma
Adrenal insufficiency
Adrenocortical carcinoma
Adrenogenital syndrome
Adrenoleukodystrophy
Aerophobia
Agoraphobia
Agrizoophobia
Agyrophobia
Aicardi syndrome
Aichmophobia
AIDS
AIDS Dementia Complex
Ainhum
Albinism
Albright's hereditary...
Albuminurophobia
Alcaptonuria
Alcohol fetopathy
Alcoholic hepatitis
Alcoholic liver cirrhosis
Alektorophobia
Alexander disease
Alien hand syndrome
Alkaptonuria
Alliumphobia
Alopecia
Alopecia areata
Alopecia totalis
Alopecia universalis
Alpers disease
Alpha 1-antitrypsin...
Alpha-mannosidosis
Alport syndrome
Alternating hemiplegia
Alzheimer's disease
Amaurosis
Amblyopia
Ambras syndrome
Amelogenesis imperfecta
Amenorrhea
American trypanosomiasis
Amoebiasis
Amyloidosis
Amyotrophic lateral...
Anaphylaxis
Androgen insensitivity...
Anemia
Anemia, Diamond-Blackfan
Anemia, Pernicious
Anemia, Sideroblastic
Anemophobia
Anencephaly
Aneurysm
Aneurysm
Aneurysm of sinus of...
Angelman syndrome
Anguillulosis
Aniridia
Anisakiasis
Ankylosing spondylitis
Ankylostomiasis
Annular pancreas
Anorchidism
Anorexia nervosa
Anosmia
Anotia
Anthophobia
Anthrax disease
Antiphospholipid syndrome
Antisocial personality...
Antithrombin deficiency,...
Anton's syndrome
Aortic aneurysm
Aortic coarctation
Aortic dissection
Aortic valve stenosis
Apert syndrome
Aphthous stomatitis
Apiphobia
Aplastic anemia
Appendicitis
Apraxia
Arachnoiditis
Argininosuccinate...
Argininosuccinic aciduria
Argyria
Arnold-Chiari malformation
Arrhythmogenic right...
Arteriovenous malformation
Arteritis
Arthritis
Arthritis, Juvenile
Arthrogryposis
Arthrogryposis multiplex...
Asbestosis
Ascariasis
Aseptic meningitis
Asherman's syndrome
Aspartylglycosaminuria
Aspergillosis
Asphyxia neonatorum
Asthenia
Asthenia
Asthenophobia
Asthma
Astrocytoma
Ataxia telangiectasia
Atelectasis
Atelosteogenesis, type II
Atherosclerosis
Athetosis
Atopic Dermatitis
Atrial septal defect
Atrioventricular septal...
Atrophy
Attention Deficit...
Autoimmune hepatitis
Autoimmune...
Automysophobia
Autonomic dysfunction
Familial Alzheimer disease
Senescence
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

Types

There are two types:

  1. Preductal coarctation: this occurs in children, with an increased risk in Turner syndrome. The word preductal means that the narrowing is anterior to the ligamentum arteriosum.
  2. Post-ductal coarctation: this is mainly seen in adults.

Signs, symptoms and diagnosis

Arterial hypertension in the left arm with normal to low blood pressure in the right arm is classic. Poor peripheral pulses, especially of right carotid artery and the femoral arteries, may be found in severe cases.

On chest X-ray, resorption of the lower part of the ribs may be seen, due to increased blood flow over the neurovascular bundle that runs there. Coarctation of the aorta can be accurately diagnosed with magnetic resonance angiography or echocardiogram.

Therapy

Therapy is conservative if asymptomatic, but may require surgical resection of the narrow segment if there is arterial hypertension. In some cases angioplasty can be performed to dilate the narrowed artery. If the coarctation is left untreated, arterial hypertension may become permanent due to irreversible changes in some organs (such as the kidney).

Read more at Wikipedia.org


[List your site here Free!]


Noninvasive imaging modalities in coarctation of the aorta
From CHEST, 10/1/04 by Abdulhalim Kinsara

Coarctation of the aorta is characterized by narrowing of the aorta just distal to the left subclavian artery. It has a male preponderance and is frequently associated with hypoplasia of the aortic arch and isthmus. Other associated conditions include bicuspid aortic valve, dilated aortic root, mitral valve abnormalities, and intracranial aneurysm. (1,2) Bicuspid aortic valve is the most common associated lesion occurring in about half of the patients. Coarctation of the aorta imposes a pressure load on the left ventricle, resulting in proximal systemic hypertension that may persist after surgery if correction is performed beyond 5 years of age. (3) Patients who have surgical correction for coarctation are at risk for long-term complications including death. (1,4,5) There were 87 late deaths, with a mean age of death of 38 years in 646 such patients followed up at the Mayo Clinic. The most common cause of death was coronary artery disease, followed by sudden death, heart failure, stroke, and ruptured aortic aneurysm. (5) Regular follow-up with aggressive treatment of risk factors for coronary artery- disease is clearly necessary in these patients.

There are several surgical procedures for aortic coarctation, including resection with end-to-end anastomosis, resection with replacement by a tube graft, patch angioplasty, and bypass grafts. There is increasing interest in the endovascular management of coarctation by angioplasty alone or with stenting, particularly in adult patients with this condition. (6-8) This approach has the advantage that it can be performed by the percutaneous approach and can potentially avoid some of the serious complications associated with surgery. (8) Residual abnormalities of the aorta both at the site of coarctation repair and elsewhere are common in patients who have undergone either surgery or percutaneous dilatation. (4-8) Recoarctation can occur such that 15% of patients require repeat intervention in 5 years. (4) Aortic aneurysm at the site of the surgical repair occurs in up to 5% of patients after surgical repair, and is also a significant complication in patients who have undergone percutaneous angioplasty. (4-8) The development of recoarctation and aneurysm formation increases the risk of serious complications such as aortic dissection and rupture. (5) Thus, these patients not only need comprehensive and regular follow-up to optimize the management of hypertension and other risk factors for coronary artery disease, but they also require long-term follow-up for aortic complications such as recoarctation and aneurysm formation.

Different noninvasive imaging modalities can be used in the assessment and follow-up of patients with native or repaired coarctation, and the advantages and limitations of echocardiography (transthoracic and transesophageal), CT, and MRI are summarized in Table 1. Transthoracic echocardiography is ideal for the initial assessment, since it provides comprehensive assessment of valvular and ventricular function, in addition to reliable assessment of the pressure gradient across the coarctation. It is widely available, although technical skill is required to obtain optimal velocity profile across the coarctation to calculate the pressure gradient.

Transesophageal echocardiography (TEE) has an important role in patients with native and repaired coarctation. The entire thoracic aorta can be image, except for a small segment of the ascending aorta, which is obscured by the trachea or right bronchus. It is our experience that endovascular stent can be adequately visualized by TEE, although optimal velocity profile at the site of coarctation cannot be obtained. We frequently used TEE in addition to CT in the follow-up of patients who have endovascular stent for coarctation. While MRI and CT are not suitable for intraoperative applications, TEE is ideal for this setting to monitor endovascular coarctation repair by angioplasty or stenting and to assess for procedural complications including dissection and stent dislodgement. (9,10)

High-resolution images of the entire aorta including the coarctation segment can be obtained by MRI, which provides detailed anatomic information for the planning of invasive intervention such as surgery or percutaneous angioplasty. By virtue of its ability to provide multiple oblique-sagittal planes of the aorta, MRI is particularly suited in the follow-up of patients who have undergone surgical repair for coarctation, since the aortic arch and proximal descending aorta in these patients tend to be tortuous and difficult to image in the proper long axis view. (11) However, there are situations where MRI is not the imaging modality of choice. One obvious situation is in patients who cannot undergo MRI because they have metallic prostheses such as pacemakers. Optimal images cannot be obtained in patients who have had treatment with endovascular stents since the stent artifact generally obscures the aortic segment that has been stented. In these patients the location and morphology of the stent can best be assessed by using both CT and TEE. CT is less affected by the stent artifact and can provide high-resolution images in the transverse plane. Compared to MRI, the aortic arch is not as well seen by CT because it is imaged obliquely and reconstructed CT sagittal views have limited resolution.

Although both MRI and CT can give high-quality images, measurements of the aorta by MRI and CT are not interchangeable. In this issue of CHEST (see page 1169), Hager et al showed that the differences between the two techniques in aortic measurements can be as large as 9 mm. This is an important message to bear in mind when assessing for progression of aortic dilatation in patients with Marfan syndrome, repaired coarctation, or chronic aortic dissection. Ideally, only serial measurements by the same method should be compared to minimize variability, and even then it is important to be aware of the intraobserver and interobserver variabilities of the specific technique (whether it is echocardiography, MRI, or CT) in one's own institution. We need to avoid basing management decision on "measurements to different investigators on different studies with perhaps different methods."

Patients with native and repaired coarctation are at risk for long-term complications and require regular follow-up. Understanding the advantages and limitations of the noninvasive imaging modalities should lead to their proper use and result in an improved long-term outcome for these patients.

REFERENCES

(1) Campbell M. Natural history of coarctation of the aorta. Br Heart J 1970; 32:633-640

(2) Perloff JK. Coarcation of the aorta. In: The clinical recognition of congenital heart disease. Philadelphia, PA: W.B. Saunders, 1999; 132-169

(3) Behl PR, Sante P, Blesovsky A. Isolated coarctation of the aorta: surgical treatment and late results: eighteen years' experience. J Cardiovasc Surg 1988; 29:509 517

(4) Beekman RH, Rocchini AP, Behrendt DM, et al. Long-term outcome after repair of coarctation in infancy: subclavian angioplasty does not reduce the need for reoperation. J Am Coll Cardiol 1986; 8:1406-1411

(5) Cohen M, Fuster V, Steele PM, et al. Coarctation of the aorta: long-term follow-up and prediction of outcome after surgical correction. Circulation 1989; 80:840-845

(6) Macdonald S, Thomas SM, Cleveland TJ, et al. Angioplasty or stenting iii adult coarctation of the aorta? A retrospective single center analysis over a decade. Cardiovasc Intervent Radiol 2003; 26:357-364

(7) Tyagi S, Singh S, Mulkhopadhyay S, et al. Self- and balloon expandable stent implantation for severe native coarctation of aorta in adults. Am Heart J 2003; 146:920-928

(8) Hernandez-Gonzalez M, Solorio S, Conde-Carmona I, et al. Intraluminal aortoplasty vs. surgical aortic resection in congenital aortic coarctation: a clinical random study in pediatric patients. Arch Med Res 2003; 34:305-310

(9) Schutz W, Gauss A, Meierhenrish R, et al. Transesophageal echocardiographic guidance of thoracic aortic stent graft implantation. J Endovasc Ther 2002; 9(suppl):II14-II19

(10) Engvall J, Sjoqvist L, Nylander E, et al. Biplane transesophageal echocardiography, transthoracic Doppler, and magnetic resonance imaging in the assessment of coarctation of the aorta. Eur Heart J 1995; 16:1399-1409

(11) Therrien J, Thorne SA, Wright A, et al. Repaired coarctation: a "cost-effective" approach to identify complications in adults. J Am Coll Cardiol 2000; 35:997-1002

Abdulhalim Kinsara, MD

Jeddah, Saudi Arabia

Kwan-Leung Chan, MD

Ottowa, Canada

Dr. Kinsara is Staff Cardiologist, Jeddah National Guard Hospital, Jeddah, Saudi Arabia. Dr. Chan is Professor of Medicine, University of Ottawa, Ottawa, Canada.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (e-mail: permissions@chestnet.org).

Correspondence to: Kwan-Leung Chan, MD, University of Ottowa Heart Institute, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada; e-mail: kchau@ottowaheart.ca

COPYRIGHT 2004 American College of Chest Physicians
COPYRIGHT 2004 Gale Group

Return to Aortic coarctation
Home Contact Resources Exchange Links ebay