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Lamisil

Terbinafine hydrochloride, sold as Lamisil tablets in the U.S., is often prescribed for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (Tinea unguium). more...

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It is also sold as a 1% cream or powder for use on suface infections such as jock itch (Tinea cruris) or athlete's foot (Tinea pedis).

Nail fungus infections live deep under the nail in the nail bed. Surface treatments may not be able to reach it in sufficient amounts, so terbinafine hydrochloride is given orally in tablet form, which is absorbed through the bloodstream to reach the infection; this method can cause hepatotoxicity, or liver damage, as well as other serious side effects, so those taking Lamisil tablets often have blood screenings every month. Many health insurance companies consider these infections to be a cosmetic problem, and either do not cover the cost of the months-long course of Lamisil, which can run into the thousands of dollars, or recommend use of less expensive alternatives like fluconazole.

The tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride, which is a white fine crystalline powder that is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Chemically, it is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1- naphthalenemethanamine hydrochloride. The empirical formula C21H26CIN with a molecular weight of 327.90

  • Active Ingredients: Terbinafine hydrochloride (equivalent to 250 mg base)
  • Inactive Ingredients: Colloidal silicon dioxide, Hydroxypropyl methylcellulose USP, Sodium starch glycolate, Magnesium stearate, Microcrystalline cellulose.

Read more at Wikipedia.org


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How-tos for cuticle care: expert advice on how to keep this fragile skin, and your nails, healthy
From Shape, 12/1/04 by Jody Buffalo

Ragged cuticles can be annoying, but whatever you do, don't snip or bite them; they're the most important part of your nails. Here, dermatologist Phoebe Rich, M.D., of Portland, Ore., explains the correct way to care for this delicate skin.

THE BASIC FACTS

Fingernails and toenails are made of a protein called keratin. The exposed portion is called the nail plate and is composed of dead, compacted and hardened keratin. The nail bed is the skin beneath the nail itself. The cuticle is the dead skin that overlaps your nail plate at the base to form a seal. The nail is formed beneath the cuticle at the matrix.

WHAT TO LOOK FOR

In forming a seal between the skin and the nail plate, cuticles protect the body from bacteria, yeast, even fungus. Here's what to watch out for:

* Minor redness, a symptom of irritation, can develop from cutting your cuticles or from immersing hands in household cleaning products.

* Itchiness and blisters around the cuticles and nails can be triggered by methyl methacrylate (MMA), used in the application of acrylic nails, and tosylamid/formaldehyde resin, found in some polishes.

* Discolored debris under the nail or separation of the nail from its bed are signs of a fungal infection.

SIMPLE SOLUTIONS

To keep your nails healthy, Beauty Rx:

1. Keep cuticles from drying out. Apply a moisturizer each time you wash your hands, and don't use nail polish remover more than once a week; it's too drying.

2. Wear cotton-lined rubber gloves when using household cleaning products.

3. If cuticles look ragged, gently rub away dead skin with a soft washcloth. Never push cuticles too harshly and fight the urge to bite your cuticles.

4. Be sure that your nail technician sterilizes all tools used during a manicure, or bring your own. Notice if the stations are clean, if the nail technician washes her hands between clients and if her license is displayed.

5. If you have an inflammation or an infection, see a dermatologist or podiatrist for a topical antifungal or antibacterial cream, or prescription oral antifungal like Lamisil tablets.

RELATED ARTICLE: THE NAIL

1. nail plate

2. nail bed

3. cuticle

4. matrix

5. bone

RELATED ARTICLE: WHAT WORKS

"There are a lot of misconceptions about cuticles--people think that they need to attack them," says Phoebe Rich, M.D., a clinical associate professor of dermatology at Oregon Health & Science University in Portland. "It's important to not let cuticles be cut, scraped or pushed to the point of breaking the seal between the nail and the skin," explains Rich, a former president of the Council for Nail Disorders and frequent speaker on nail safety for the American Academy of Dermatology. If your cuticle has grown way out on your nail, the best thing to do is gently rub away the dead skin with a towel. Never allow cuticles to be pushed and prodded with metal implements, Rich says. "Savvy consumers who follow these simple guidelines can protect their nails and keep them healthy and looking great."

COPYRIGHT 2004 Weider Publications
COPYRIGHT 2004 Gale Group

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