In this study, the effects of latanoprost on hair growth were evaluated in macaque monkeys that are models of androgenetic alopecia (AGA). 8 monkeys were divided into two groups: one group received a daily topical application of 50microg/ml of latanoprost for 5 months, and the control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500microg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair regrowth was evaluated by monthly photographs and phototrichographic analysis. Fifty microg/ml of latanoprost caused minimal hair regrowth whereas 500microg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further studies this agent can be used in humans. However, this research suggests possible new agents will be available for AGA.
Uno H, Zimbric ML, Albert DM, Stjernscbantz J. Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: a pilot study. Acta Derm Venereol 2002; 82(1):7-12.
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