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Leukeran

Chlorambucil (marketed as Leukeran) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally. more...

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In the past, it has been used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma. It also has been used as an immunosuppressive drug for various autoimmune and inflammatory conditions, e.g. nephrotic syndrome. Its current use is mainly for CLL as it is well tolerated by most patients, though this has been primarily replaced by fludarabine.

Side effects include myelosuppression (anemia, neutropenia, thrombocytopenia).

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Folic and folinic acid: Cause for confusion
From Nurse Practitioner, 10/1/00 by Cohen, Hedy

Two medication errors occurred because of confusion between folinic acid and folic acid. Folinic acid, also known as leucovorin calcium, is a useful antidote to folic acid antagonists.

In one case, a hospital pharmacy correctly dispensed leucovorin calcium when folinic acid was ordered. However, a nurse thought the order was for folic acid and borrowed a dose of folic acid from surplus patient supplies that had not yet been returned to the pharmacy. In the other case, a unit secretary and a pharmacist transcribed a folinic acid order as folic acid.

Prescribers should use the name leucovorin calcium when prescribing folinic acid. Another caution regarding this drug name: Communicating leucovorin calcium without stating "calcium" could cause it to be confused with Leukeran (chlorambucil).

Copyright Springhouse Corporation Oct 2000
Provided by ProQuest Information and Learning Company. All rights Reserved

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