Levofloxacin chemical structure
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Levaquin

Levofloxacin is a fluoroquinolone antibiotic, marketed by Ortho-McNeil under the brand name Levaquin. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin. more...

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Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism is identified, levofloxacin is sometimes discontinued and the patient may be switched to an antibiotic with a narrower spectrum

Gram-positive bacteria

  • Enterococcus faecalis (many strains are only moderately susceptible)
  • Staphylococcus aureus (methicillin-susceptible strains)
  • Staphylococcus epidermidis (methicillin-susceptible strains)
  • Staphylococcus saprophyticus
  • Streptococcus pneumoniae (including penicillin-resistant strains*)
  • Streptococcus pyogenes

Levofloxacin only has moderate Gram-positive coverage; beta-lactams (e.g. ceftriaxone) or glycopeptides (e.g. vancomycin) are generally preferred for this indication.

Gram-negative bacteria

  • Enterobacter cloacae
  • Klebsiella pneumoniae
  • Pseudomonas aeruginosa
  • Escherichia coli
  • Legionella pneumophila
  • Serratia marcescens
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Haemophilus parainfluenzae
  • Proteus mirabilis
  • Campylobacter

Other

  • Chlamydia pneumoniae
  • Mycoplasma pneumoniae

Some information extracted from Levaquin Prescribing information.

Read more at Wikipedia.org


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Daiichi Wins Lawsuit Against Mylan Pharmaceuticals Regarding Patents for Levofloxacin
From JCNN News Summaries, 12/28/05

Tokyo, Japan, Dec 27, 2005 - (JCN) - Daiichi Sankyo has announced that its wholly owned subsidiary Daiichi Pharmaceutical has won the lawsuit against Mylan Pharmaceuticals.

Specifically, the US Court of Appeals for the Federal Circuit has affirmed the validity of US patent (No. 5,053,407) on levofloxacin, a broad spectrum synthetic antibacterial agent held by Daiichi. Consequently, Mylain is prohibited from producing any generic version of levofloxacin until Daiichi's patent expires.

Currently, levofloxacin is marketed under the trade names of Cravit in Japan and Levaquin in the US.

Copyright [c] 2005 Japan Corporate News Network. All rights reserved.

COPYRIGHT 2005 Japan Corporate News Network K.K.
COPYRIGHT 2005 Gale Group

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