Levofloxacin chemical structure
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Levaquin

Levofloxacin is a fluoroquinolone antibiotic, marketed by Ortho-McNeil under the brand name Levaquin. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin. more...

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Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism is identified, levofloxacin is sometimes discontinued and the patient may be switched to an antibiotic with a narrower spectrum

Gram-positive bacteria

  • Enterococcus faecalis (many strains are only moderately susceptible)
  • Staphylococcus aureus (methicillin-susceptible strains)
  • Staphylococcus epidermidis (methicillin-susceptible strains)
  • Staphylococcus saprophyticus
  • Streptococcus pneumoniae (including penicillin-resistant strains*)
  • Streptococcus pyogenes

Levofloxacin only has moderate Gram-positive coverage; beta-lactams (e.g. ceftriaxone) or glycopeptides (e.g. vancomycin) are generally preferred for this indication.

Gram-negative bacteria

  • Enterobacter cloacae
  • Klebsiella pneumoniae
  • Pseudomonas aeruginosa
  • Escherichia coli
  • Legionella pneumophila
  • Serratia marcescens
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Haemophilus parainfluenzae
  • Proteus mirabilis
  • Campylobacter

Other

  • Chlamydia pneumoniae
  • Mycoplasma pneumoniae

Some information extracted from Levaquin Prescribing information.

Read more at Wikipedia.org


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Ortho-McNeil
From Drug Store News, 9/12/05 by James Frederick

The FDA last month approved a new five-day 750 mg once-daffy regimen of Ortho-McNeil's Levaquin (levofloxacin) to treat acute bacterial sinusitis.

The newly approved regimen is as effective as a 10-day course of Levaquin 500 mg. Levaquin generated $1.3 billion in sales in 2004.

According to the National Ambulatory Medical Care Survey, sinusitis is the fifth most common condition for which an antibiotic is prescribed. Eachyear in the United States there are an estimated 20 million cases of acute bacterial sinusitis.

COPYRIGHT 2005 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2005 Gale Group

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