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Levitra

Vardenafil (Levitra) is a PDE5 inhibitor used in the treatment of erectile dysfunction. It can assist men with this disorder in achieving and maintaining an erection during sexual activity. more...

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As a PDE5 inhibitor, vardenafil is closely related in both function and marketing to sildenafil and tadalafil; it has a relatively short effective time, comparable to sildenafil.

History

Vardenafil was co-marketed by Bayer Pharmaceuticals and GlaxoSmithKline (GSK) under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been "transferred back" to Bayer in many markets outside of the United States. In Italy, Bayer markets the product as Levitra and GSK markets the product as Vivanza. Due to European Union trade rules, Parallel Imports made result in the Vivanza branded packs being seen alongside Levitra packs in pharmacies in other EU member states.

Clinical use

Main page: PDE5 inhibitor

Indications and contraindications are as for other PDE5 inhibitors.

Adverse drug reactions

More common adverse drug reactions (ADRs) are as per other PDE5 inhibitors and are listed on that page.

Common vardenafil-specific ADRs include: nausea. Infrequent ADRs include: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypertension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, priapism. (Rossi, 2004)

Dose forms

It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 25-60 minutes prior to sexual activity, with a maximum dose frequency of once per day.

In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.

Reference

Rossi S (Ed.) (2004). Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2

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HIV - Health Hot Line
From Ebony, 3/1/04

EVERYONE agrees: Black women are at risk. According to the latest statistics compiled by the D.C.-based Black Women s Health Imperative (BWHI), African-American women make up about 64 percent of new cases of HIV--the virus that causes AIDS. The impact on our community is potentially devastating because HIV-infected African-American women are more likely to be poor, to be without health insurance, and to care for children under age 18, according to BWHI (www.BlackWomensHealth.org). They also are more likely to infect children with HIV due to pregnancy.

HIV is cutting a path across demographics among Black women. On the one hand, HIV/AIDS cases appear to be getting younger with more than half of all new HIV infections reported among teenage girls, according to the most recent statistics from the Centers for Disease Control and Prevention. But now there is a new cause for concern--the growing rate of HIV infection among older women. They tend not to use condoms because they are no longer concerned about getting pregnant. When you combine that practice with the increase in sexually active older men--due to sex pills like Viagra and Levitra--you have the recipe for disaster.

And the problem is not going away. Currently there are 40 million people worldwide who are HIV-positive. But by 2010 there could be as many as 100 million HIV cases outside of Africa. Central Intelligence Agency Director George Tenet has told the Senate Intelligence Committee that HIV/AIDS actually poses a national security threat to the United States. That is why there has been an increased push to redouble efforts for development of an AIDS vaccine.

Early diagnosis is critical. Many have looked to highly visible people who are living with HIV--people like Ervin (Magic) Johnson--as a source of hope that HIV doesn't have to develop into full-blown AIDS. But some HIV survivors are forestalling AIDS with a regimen of very expensive drug-therapy "cocktails." That takes insurance. Black women especially are urged to screen sexual partners carefully. If he doesn't want to be honest about his sexual history, then he should be history. And latex condoms are a must when you are sexually involved.

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