Image:Lexapro logo.pngescitalopram (free base) structure
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Lexapro

Escitalopram is a medication developed by the Danish pharmaceutical company Lundbeck, that acts as a selective serotonin reuptake inhibitor or SSRI. It is typically used as an antidepressant to treat depression associated with mood disorders although also may be used in the treatment of body dysmorphic disorder and anxiety. In the United States, the drug is marketed under the name Lexapro® by Forest Laboratories, Inc. In Canada and Europe, the drug is marketed under the name Cipralex® by Lundbeck Canada, Inc. more...

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Escitalopram oxalate is derived from the drug citalopram which is made up of two mirror-image isomers, only one of which is thought to be an effective medication. Lundbeck has split the isomers apart, taken the active isomer and has licensed it as the new drug escitalopram. Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram.

Escitalopram was released shortly before the patent for citalopram was due to expire. The expiration of a patent means other companies can legally produce cheaper generic versions. Escitalopram is subject to a new patent. Critics have argued that escitalopram, and the subsequent marketing campaign to persuade mental health professionals to prescribe it, is a cynical ploy to promote sales of a virtually identical but considerably more expensive drug. In defence of the new drug, Lundbeck has claimed that the drug has additional benefits over the older citalopram and other antidepressant drugs on the market, mainly better tolerability .

Withdrawal symptoms

A possible withdrawal symptom from Escitalopram is a type of spontaneous nerve pulse, described by some patients as a feeling of small electric shocks, which may be accompanied by dizziness. These pulses may be short in duration, only milliseconds long, affect any region of the body, and recur up to several times a minute, throughout all waking hours. They can be increased by physical activity, but are not solely linked to muscular activity.

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Escitalopram for depression - Lexapro - STEPS
From American Family Physician, 12/1/03 by Santhi Masilamani

Safety: To date, no serious adverse effects have been associated with escitalopram. One study (1) demonstrated a slightly greater likelihood of activation of mania/hypomania in the treatment group as compared with the placebo group (0.1 percent versus zero percent). Therefore, as with other antidepressants, escitalopram should be used with caution in patients with a history of mania or hypomania. Escitalopram has not been evaluated in patients with seizure disorder or in patients with recent myocardial infarction or unstable heart disease. Because escitalopram has weak or negligible effects on the cytochrome P450 system, the potential for drug interactions is low. (2) However, as with other SSRIs, escitalopram should not be used in combination with a monoamine oxidase inhibitor (MAOI), or within 14 days of discontinuing an MAOI. It also should not be given with citalopram because it is the active isomer of that drug. Escitalopram is classified in pregnancy category C, and there have been no studies evaluating the risk of its use in nursing mothers. (1)

Tolerability: The tolerability profile of escitalopram is predictable and similar to that of citalopram.3 In research trials, pooled dropout rates because of adverse events in patients taking escitalopram, 10 mg daily, were similar to those in patients receiving placebo (4.2 versus 2.5 percent; P = .5).4 Nausea, insomnia, somnolence, and sexual dysfunction (ejaculation disorder) are more common than with placebo and are dosage related.

Effectiveness: In comparison with placebo, escitalopram at dosages of both 10 mg and 20 mg daily decreases scores from baseline in the MADRS (Montgomery Asberg Depression Rating Scale), HAM-D (Hamilton Rating Scale for Depression), and CGI-S (Clinical Global Impression-Severity Scale) more than placebo. (4) Of note, citalopram, in a dosage of 40 mg daily, was not more effective than escitalopram at 10 mg daily on the majority of the major efficacy outcome variables. (2) While there are limited data comparing escitalopram to other SSRIs or other classes of antidepressants, one would expect it to be as effective as citalopram, which is in turn similar in efficacy to fluoxetine (Prozac). (5) In people who respond to treatment, escitalopram is more effective than placebo in preventing relapse over 36 weeks of continued therapy (26 versus 40 percent, absolute risk reduction: 14 percent; number needed to treat: 7.) (2) Escitalopram has not been studied in patients younger than 18 years.

Price: A one-month supply of escitalopram (10 mg daily) costs approximately $67, compared with $72 for citalopram (20 mg daily), $80 for generic fluoxetine (20 mg daily), $80 for sertraline (Zoloft; 50 mg daily), and $84 for paroxetine (Paxil; 20 mg daily). Prices are based on the starting dosage for each drug, as listed in Red Book, Montvale, N.J.: Medical Economics Data, 2003. (6)

Simplicity: Escitalopram is available as scored 10-mg and 20-mg tablets. The recommended starting dosage is 10 mg once daily.

Bottom line: While escitalopram has proved to be an effective treatment for major depression, it has not been shown to be significantly more effective, safer, or better tolerated than citalopram or other antidepressants.

REFERENCES

(1.) Forest Laboratories. Lexapro (escitalopram) package insert. Accessed November 13, 2003, at: http://www.lexapro.com/pdfs/lexapro_pi.pdf.

(2.) Burke WJ. Escitalopram. Expert Opin Investig Drugs 2002;11:1477-86.

(3.) Waugh J, Goa KL. Escitalopram: a review of its use in the management of major depressive and anxiety disorders. CNS Drugs 2003;17:343-62.

(4.) Burke WJ, Gergel I, Bose A. Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients. J Clin Psychiatry 2002;63:331-6.

(5.) Patris M, Bouchard JM, Bougerol T, Charbonnier JF, Chevalier JF, Clerc G, et al. Citalopram versus fluoxetine: a double-blind, controlled, multicentre, phase III trial in patients with unipolar major depression treated in general practice. Int Clin Psychopharmacol 1996;11:129-36.

(6.) Red Book. Montvale, N.J.: Medical Economics Data, 2003.

Santhi Masilamani, Pharm.D., CDE, is a clinical pharmacy specialist, Community Health Program, at Harris County Hospital District, Houston, Texas. Sara C. Ruppelt, Pharm.D., is assistant professor in the Department of Psychiatry at Baylor College of Medicine, Houston, Texas.

The series coordinator of STEPS is Allen F. Shaughnessy, Pharm.D., director of medical education at Pinnacle Health System, Harrisburg, Pa.

COPYRIGHT 2003 American Academy of Family Physicians
COPYRIGHT 2003 Gale Group

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