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Lithotabs

Lithium salts are chemical salts of lithium used primarily in the treatment of bipolar disorder as mood stabilizing drugs. They are also sometimes used to treat depression and mania. more...

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Lithium carbonate (Li2CO3), sold as Carbolith®, Cibalith-S®, Duralith®, Eskalith®, Lithane®, Lithizine®, Lithobid®, Lithonate® and Lithotabs®, is the most commonly prescribed, whilst the citrate salt lithium citrate (Li3C6H5O7), the sulfate salt lithium sulfate (Li2SO4), the oxybutyrate salt lithium oxybutyrate (C4H9LiO3) and the orotate salt lithium orotate are alternatives.

Lithium is widely distributed in the central nervous system and interacts with a number of neurotransmitters and receptors, decreasing noradrenaline release and increasing serotonin synthesis.

History

The use of lithium salts to treat mania was first proposed by the Australian psychiatrist John Cade in 1949, after he discovered the effect of first lithium urate, and then other lithium salts, on animals. Cade soon succeeded in controlling mania in chronically hospitalized patients. This was the first successful application of a drug to treat mental illness, and opened the door for the development of medicines for other mental [[problems in the next decades.

The rest of the world was slow to adopt this revolutionary treatment, largely because of deaths which resulted from even relatively minor overdosing, and from use of lithium chloride as a substitute for table salt. Largely through the research and other efforts of Denmark's Mogens Schou in Europe, and Samuel Gershon in the U.S., this resistance was slowly overcome. The application of lithium for manic illness was approved by the United States Food and Drug Administration in 1970.

Treatment

Lithium treatment is used to treat mania in bipolar disorder. Initially, lithium is often used in conjunction with antipsychotic drugs as it can take up to a week for lithium to have an effect. Lithium is also used as prophylaxis for depression and mania in bipolar disorder. Also, it is sometimes used for other disorders, like cycloid psychosis, unipolar depression, migraine and others. It is sometimes used as an "augmenting" agent, to increase the benefits of standard drugs used for unipolar depression. Lithium treatment is generally considered to be unsuitable for children.

Mechanism of Action

The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown, but it is possible that Li+ produces its effects by interacting with the transport of monovalent or divalent cations in neurons. However, because it is a poor substrate at the sodium pump, it cannot maintain a membrane potential and only sustains a small gradient across biological membranes. Yet Li+ is similar enough to Na+ in that under experimental conditions, Li+ can replace Na+ for production of a single in neurons. Perhaps most the most interesting characteristic of Li+, is that it produces no obvious psychotropic effects (such as sedation, depression, euphoria) in normal individuals at therapeutic concentrations, differentiating it from the other psychoactive drugs.

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Conduct disorder
From Gale Encyclopedia of Medicine, 4/6/01 by Paula Anne Ford-Martin

Definition

Conduct disorder (CD) is a behavioral and emotional disorder of childhood and adolescence. Children with conduct disorder act inappropriately, infringe on the rights of others, and violate the behavioral expectations of others.

Description

Conduct disorder is present in approximately 9% of boys and 2-9% of girls under the age of 18. Children with conduct disorder act out aggressively and express anger inappropriately. They engage in a variety of antisocial and destructive acts, including violence towards people and animals, destruction of property, lying, stealing, truancy, and running away from home. They often begin using and abusing drugs and alcohol, and having sex at an early age. Irritability, temper tantrums, and low self-esteem are common personality traits of children with conduct disorder.

Causes & symptoms

The Diagnostic and Statistical Manual of Mental Disorders fourth edition, (DSM-IV) describes two sub-types of conduct disorder, one beginning in childhood and the other in adolescence. There is no known cause. Researchers and physicians suggest that this disease may be caused by the following:
  • Poor parent-child relationships
  • Dysfunctional families
  • Drug abuse
  • Physical abuse
  • Poor relationships with other children
  • Cognitive problems leading to school failures
  • Brain damage
  • Biological defects.

Difficulty in school is an early sign of potential conduct disorder problems. While the patient's IQ tends to be in the normal range, they can have trouble with verbal and abstract reasoning skills and may lag behind their classmates, and consequently, feel as if they don't "fit in." The frustration and loss of self-esteem resulting from this academic and social inadequacy can trigger the development of conduct disorder.

A dysfunctional home environment can be another major contributor to conduct disorder. An emotionally, physically, or sexually abusive home environment, a family history of antisocial personality disorder, or parental substance abuse can damage a child's perceptions of himself and put him on a path toward negative behavior. Other less obvious environmental factors can also play a part in the development of conduct disorder. Long-term studies have shown that maternal smoking during pregnancy may be linked to the development of conduct disorder in boys. Animal and human studies point out that nicotine can have undesirable effects on babies. These include altered structure and function of their nervous systems, learning deficits, and behavioral problems. In a study of 177 boys ages 7-12 years, those with mothers who smoked over one half a package of cigarettes daily while pregnant were more apt to have a conduct disorder than those with mothers who did not smoke.

Other conditions that may cause or co-exist with conduct disorder include head injury, substance abuse disorder, major depressive disorder, and attention deficit hyperactivity disorder (ADHD). Thirty to fifty percent of children diagnosed with ADHD, a disorder characterized by a persistent pattern of inattention and/or hyperactivity, also have conduct disorder.

The Diagnostic and Statistical Manual of Mental Disorders, the diagnostic standard for mental health professionals in the United States, defines conduct disorder as a repetitive behavioral pattern of violating the rights of others or societal norms. Three of the following criteria, or symptoms, are required over the previous 12 months for a diagnosis of conduct disorder (one of the three must have occurred in the past six months):

  • Bullies, threatens, or intimidates others
  • Picks fights
  • Has used a dangerous weapon
  • Has been physically cruel to people
  • Has been physically cruel to animals
  • Has stolen while confronting a victim (for example, mugging or extortion)
  • Has forced someone into sexual activity
  • Has deliberately set a fire with the intention of causing damage
  • Has deliberately destroyed property of others
  • Has broken into someone else's house or car
  • Frequently lies to get something or to avoid obligations
  • Has stolen without confronting a victim or breaking and entering (e.g., shoplifting or forgery)
  • Stays out at night; breaks curfew (beginning before 13 years of age)
  • Has run away from home overnight at least twice (or once for a lengthy period)
  • Is often truant from school (beginning before 13 years of age).

Diagnosis

Conduct disorder is diagnosed and treated by a number of social workers, school counselors, psychiatrists, and psychologists. Genuine diagnosis may require psychiatric expertise to rule out such conditions as bipolar disorder or attention deficit hyperactivity disorder (ADHD). A comprehensive evaluation of the child should ideally include interviews with the child and parents, a full social and medical history, a cognitive evaluation, and a psychiatric exam. One or more clinical inventories or scales may be used to assess the child for conduct disorder--including the Youth Self-Report, the Overt Aggression Scale (OAS), Behavioral Assessment System for Children (BASC), Child Behavior Checklist (CBCL), and Diagnostic Interview Schedule for Children (DISC). The tests are verbal and/or written and are administered in both hospital and outpatient settings.

Treatment

Treating conduct disorder requires an approach that addresses both the child and his environment. Behavioral therapy and psychotherapy can help a child with conduct disorder to control his anger and develop new coping skills. Family group therapy may also be effective in some cases. Parents should be counseled on how to set appropriate limits with their child and be consistent and realistic when disciplining. If an abusive home life is at the root of the conduct problem, every effort should be made to move the child into a more supportive environment. Parent training programs are increasing in number.

For children with coexisting ADHD, substance abuse, depression, or learning disorders, treating these conditions first is preferred, and may result in a significant improvement to the conduct disorder condition. In all cases of conduct disorder, treatment should begin when symptoms first appear. Recent studies have shown Ritalin to be a useful drug for both ADHD and CD.

When aggressive behavior is severe, mood stabilizing medication, including lithium (Cibalith-S, Eskalith, Lithane, Lithobid, Lithonate, Lithotabs), carbamazepine (Tegretol, Atretol), and propranolol (Inderal), may be an appropriate option for treating the aggressive symptoms. However, placing the child into a structured setting or treatment program such as a psychiatric hospital may be just as beneficial for easing aggression as medication.

Prognosis

The prognosis for children with conduct disorder is not bright. Follow-up studies of conduct disordered children have shown a high incidence of antisocial personality disorder, affective illnesses, and chronic criminal behavior later in life. However, proper treatment of co-existing disorders, early identification and intervention, and long-term support may improve the outlook significantly.

Prevention

A supportive, nurturing, and structured home environment is believed to be the best defense against conduct disorder. Children with learning disabilities and/or difficulties in school should get immediate and appropriate academic assistance. Addressing these problems when they first appear helps to prevent the frustration and low self-esteem that may lead to conduct disorder later on.

Key Terms

ADHD
Attention deficit hyperactivity disorder; a disorder characterized by a persistent pattern of inattention and/or hyperactivity.
Major depressive disorder
A mood disorder characterized by profound feelings of sadness or despair.

Further Reading

For Your Information

    Books

  • Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association.
  • Maxmen, Jerrold S., and Nicholas G. Ward. "Disorders Usually First Diagnosed in Infancy, Childhood, or Adolescence." In Essential Psychopathology and Its Treatment, 2nd ed. New York: W.W. Norton, 1995.
  • Sholevar, Pirooz. Conduct Disorders in Childhood and Adolescence. Washington, D.C.: American Psychiatric Press, Inc., 1995.

    Periodicals

  • Brodkin, Adele M. and Melba Coleman. "He's Trouble with a Capital T: What Can You Do for a Child with Conduct Disorder?" Instructor, (April 1996): 18-9.
  • Thompson, L. L., et al. "Contribution of ADHD Symptoms to Substance Problems and Delinquency in Conduct-Disordered Adolescents." Journal of Abnormal Child Psychology, 24 (3)(June 1996): 325-47.

    Organizations

  • American Academy of Child and Adolescent Psychiatry (AACAP). 3615 Wisconsin Ave. NW, Washington, DC 20016. (202)966-7300. http://www.aacap.org/.
  • Children and Adults with Attention Deficit Disorder (CH.A.D.D.). 499 Northwest 70th Avenue, Suite 101, Plantation, FL 33317. (800)233-4050. http://www.chadd.org/.

Gale Encyclopedia of Medicine. Gale Research, 1999.

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