Lufenuron is stored in the animals body fat and transferred to adult fleas through their bite. Adult fleas transfer it to their eggs by its presence in the mother fleas blood or by the larva feeding on digested blood.

The method of action for lufenuron is to inhibit the production of chitin in larval fleas. Without chitin a larval flea will never develop an exoskeleton. Attacking the ability to create chitin also makes lufenuron an effective remedy against fungal infections and some internal parasites, such as heartworm or ringworm.

It has no known toxic effects at any dosage on humans or other animals in the environment that do not depend on chitin though the orally administered pills sometimes cause an upset stomach with acid reflux.

CAS Number: 103055-07-8
U.S. EPA PC Code: 118205

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Petstore.com and Novartis Animal Health Announce Partnership to Benefit Pet Owners; Partnership for Pet Health Program Members Will Reap More Rewards
From Business Wire, 2/7/00

Business Editors

EMERYVILLE, Calif.--(BUSINESS WIRE)--Feb. 7, 2000

Petstore.com (www.petstore.com), a leading online source for pet products and expert advice, and Novartis Animal Health (www.novartispet.com), a leading companion animal pharmaceutical company, today announced a partnership to benefit pet owners. This new initiative will provide pet owners who visit the Petstore.com Web site with important information on pet care as well as discounts on merchandise for eligible shoppers. The effort is targeted primarily at members of Partnership for Pet Health (PPH), Novartis Animal Health's innovative pet owner membership program.

As part of this endeavor, Petstore.com will feature helpful information on heartworms and fleas as well as information about Novartis Animal Health products that help protect pets against these dangerous parasites. In addition, PPH members who visit Petstore.com will be eligible to receive discounts and special product offers.

&uot;Petstore.com was founded on the premise that pets and their owners deserve the most trusted information and expert advice,&uot; said Chris Luhnow, co-founder and president of Petstore.com. &uot;By teaming with Novartis Animal Health, Petstore.com not only continues to deliver on this promise, but also has the opportunity to provide current and new customers with a wealth of information aimed at keeping their pets happy and healthy.&uot;

The PPH membership will learn about this new opportunity at Petstore.com through multiple PPH membership mailings. The mailings will promote Petstore.com as a place to purchase non-veterinary pet supplies.

John Smith, vice president, marketing for Novartis Animal Health, applauded the partnership saying, &uot;This association with Petstore.com provides Novartis Animal Health with even more benefits to offers its PPH members. In particular, our members will receive special discounts on a large array of pet-related products. This will help us continue to build relationships with our customers in an increasingly competitive marketplace.&uot;

Partnership for Pet Health: A One-of-a-Kind Pet Owner Membership Program

Partnership for Pet Health is a pet owner membership program that reinforces the importance of regular veterinary care. PPH offers pets owners important information on pet care, as well as valuable savings on Novartis Animal Health's most popular products. Pet owners can join PPH simply by purchasing Novartis products such as, SENTINEL(R) (milbemycin oxime/lufenuron), PROGRAM(R) (lufenuron), PROGRAM(R) (lufenuron) 6 Month Injectable for Cats or INTERCEPTOR(R) (milbemycin oxime). Once enrolled, pet owners receive a PPH Welcome Kit containing a membership card and the latest issue of the educational newsletter, Pet Buzz. On an ongoing basis, members receive periodic mailings including Pet Buzz, product-related offers and important reminders regarding product renewal. (This info. Was moved here from up above.)

About Petstore.com

Created by pet experts for people who are passionate about pets, Petstore.com (http://www.petstore.com) is the definitive source for petcare solutions. The company provides expert advice and trustworthy information so pet owners can choose the right products for their pets. Petstore.com has been named by USA Today as a &uot;Hot Site of the Day&uot; and received top marks from Gomez.com. Petstore.com is based in Emeryville, CA, as was created in October 1998 by a seasoned founding team with more than 50 years of combined experience in technology, Internet business and the pet industry. Since its creation, Petstore.com has acquired Flying Fish Express, the leading online tropical fish e-tailer and formed a strategic alliance with Discovery Communications, Inc., parent company of the Animal Planet cable network.

About Novartis

Novartis is a world leader in healthcare with core businesses in pharmaceuticals, consumer health, generics, eye-care, and animal health. In 1998, the Group (including Agribusiness) achieved sales of $21.8 billion and invested more than $2.6 billion in R&. Headquartered in Basel, Switzerland, Novartis employs about 82,000 people and operates in over 140 countries around the world. The Group recently announced plans to spin off its Crop Protection and Seeds sectors and to merge them with the agrochemicals business of AstraZeneca in the second half of 2000.

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