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Valcyte

Valganciclovir hydrochloride (Valcyte®) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. more...

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Administration

Orally, available in 450 mg pink tablets. Dosing is calculated to provide appropriate doses of ganciclovir; 900 mg of valganciclovir orally every 12 hours is equivalent to 5 mg per kilogram of body weight of intravenous ganciclovir, also every 12 hours.

Pharmacokinetics

  1. Oral bioavailability is approximately 60%. Fatty foods significantly increase the bioavailability and the peak level in the serum.
  2. It takes about 2 hours to reach maximum concentrations in the serum.
  3. Valganciclovir is eliminated as ganciclovir in the urine, with a half-life of about 4 hours in people with normal kidney function.

Side effects

  • Blood: neutropenia, anemia, low platelets. Myelosuppression is one of the main side effects that may limit prolonged use of valganciclovir.
  • Gastrointestinal: diarrhea, nausea, vomiting, abdominal pain.
  • Central nervous system: fever, headache, insomnia, paresthesia, and peripheral neuropathy.
  • Ocular: retinal detachment

Read more at Wikipedia.org


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Within the Herpes and Respiratory Antiviral Subcategory HSV/VZV Products have been Key Growth Drivers, Accounting for 77% of a Market Worth $2,190m in
From Business Wire, 11/21/05

DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c28097) has announced the addition of Herpes and Respiratory Antivirals - Leaders Rise and Fall to their offering.

Within the herpes and respiratory antiviral subcategory HSV/VZV products have been key growth drivers, accounting for 77% of a market worth $2,190m in 2004. Despite lost of US branded Valtrex in 2009, the continued uptake of flu and post-transplant CMV antivirals along with the anticipated launch of first-in-class RSV antiviral, A-60444 will to some extent offset revenue loss by 2014.

The anti-infective vaccine market is poised for explosive growth, leading to a shift of R&D focus from antiviral therapy to preventative vaccination and hence a dwindling herpes and respiratory antiviral pipeline. However, clinical unmet needs mainly in CMV, VZV related post-herpetic neuralgia (PHN) and RSV maintain the call for new products.

Capitalizing on the Zovirax legacy, a large number of indication expansions and effective marketing strategies by ID leader GSK, sales of follow-up product Valtrex have experienced accelerated growth. In 2004, Valtrex achieved blockbuster status, selling $1,090m in the seven major markets.

Currently available RSV therapies are sub-optimal and expensive, being reserved for at risk immunocompromised patient groups such as neonates. With successful development and positioning of first-in-class RSV small molecule inhibitor A-60444, Arrow/Novartis could establish a new treatment paradigm in RSV.

Scope of the report:

- Market overview by geographical area and disease indication, with value analysis of clinical and commercial factors underlying product performance

- Assessment of country-specific drivers and resistors likely to impact the herpes and respiratory antiviral market

- Case study analysis of the key players in the market and further the success of follow-up products Valtrex for HSV/VZV and Valcyte for CMV

- Future market outlook per disease indication and individual products taking into account key market events in particular, patent expiries

Reasons to Purchase

- Identify key environmental opportunities and threats that will impact the use and uptake of new and existing products

- Select effective lifecycle management strategies through best-in-class case study analysis of key players in the market

- Understand and capitalize on clinical unmet needs in the market, either through lifecycle management of marketed drugs or new product development

For more information visit http://www.researchandmarkets.com/reports/c28097

COPYRIGHT 2005 Business Wire
COPYRIGHT 2005 Gale Group

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