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Mebendazole (brand name Vermox® or Pripsen®) is a drug used to combat pinworms, roundworms and hookworms. It is sometimes referred to as "MBZ". Mebendazole (C16H13N3O2) causes slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell. It is a spindle poison that induces chromosome nondisjunction. Oral dosage is 100 mg 12 hourly for 3 days.

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Echinococcosis—an emerging parasite in the immigrant population
From American Family Physician, 9/1/02 by Milad Chrieki

Echinococcosis (also known as hydatid disease) is an important public health problem in many parts of the world, especially in rural areas where sheep and cattle are raised. (1,2) Echinococcus tapeworms are parasitic organisms with a two-stage life cycle. (3,4) In the adult phase, the tapeworm lives in the intestines of the dog who is the so-called "definitive" host. A great number of other animals, especially sheep or cattle and, occasionally, humans, can become infected with the larval stage of the worm and are called "intermediate" hosts. Intermediate hosts become infected when they ingest food or water contaminated by dog feces. Most human cases occur in areas where dogs and livestock are raised together. (1-3,5)

The liver and lungs are the most common sites for cyst formation in humans, although any organ can be involved. Symptom presentation is varied and nonspecific. The diagnosis is most often arrived at when radiographic studies show space-occupying lesions of internal organs, bone, or brain. (5)

Epidemiology

Human infection, often acquired in childhood during play with infected dogs, is most common in sheep-raising areas, especially in Russia and China, but also in Europe, (6) South Africa, Australia, (7) New Zealand, the Middle East, (8) and South America. (1,9,10) Most of the new human cases that are diagnosed in the United States each year occur in members of well-defined risk groups, such as sheep farmers in the West, some Native American tribes in the Southwest, (9,11) and immigrants who acquired their infection abroad. (1,2,4) A northern strain of echinococcosis, with a life cycle in caribou, moose, and wolves, infects Native Inuit and Aleut populations in Alaska and Canada. (4)

Clinical Presentation

In humans, echinococcosis can be a serious disease, with a mortality rate of 4 to 5 percent. (12) Cyst size and location greatly influence the outcome. Most hydatid cysts develop in the liver, and most of them are asymptomatic (approximately 60 percent) at the time of diagnosis. (3) Cysts grow from 1 to 5 cm per year. (2,13)

The lung is the next most frequent site of cyst location, followed by the kidneys, muscle, spleen, soft tissue, brain, and bone. Symptoms are generally caused by a mechanical obstruction within the affected organ. (3,13) Cysts may be symptomless for 10 to 20 years until they become large enough to produce symptoms. (2) During the life of the cyst, leakage into the systemic circulation can sensitize the patient, and if a cyst ruptures suddenly, a severe allergic reaction or even anaphylaxis and death may occur. (2,3,5)

Most cases of echinococcosis are caused by infection with Echinococcus granulosus, which has a limiting membrane that surrounds the growing cysts. (7) Much less common, but more serious, is alveolar echinococcosis caused by ingestion of Echinococcus multilocularis. (5) This species does not have a limiting membrane and can grow aggressively; if left untreated, this infection is almost always fatal. (3,5,7)

Diagnosis

Echinococcosis should be considered in patients with an abdominal mass and no clearly defined diagnosis. (12) The typical appearance on imaging is a fluid-filled mass with a well-defined outer wall and internal septations.

Serologic testing is more specific, but less sensitive, than most imaging modalities. (1,3) In patients with lung cysts, false-negative results occur in up to 50 percent of infections. (2) Enzyme-linked immunoelectrotransfer blot (EITB), (11,13) where available, is the test of choice. In some studies, it has greater than 95 percent sensitivity and specificity. (13) Enzyme-linked immunosorbent assay (ELISA) has up to 84 percent sensitivity. (1) (This test can be performed at the Laboratory Corporation of America in Cypress, Calif.).

It has been reported that the detection of specific IgG1 and IgG4 serum antibodies to echinococcosis can enhance the specificity of ELISA. (1,2) Serologic tests alone cannot be used to definitively establish or exclude echinococcosis. Fine-needle aspiration is a reliable method of diagnosing cystic lesions in patients with negative or equivocal serology. The characteristic findings of tapeworm anatomic parts and eosinophilic-appearing granules in the aspirated fluid confirm the diagnosis. (13-15)

Treatment

Therapy for echinococcosis is based on the size, location, and symptomatic complications of the cysts. Surgery is the treatment of choice (2,3,13); however, removal of the main cyst mass may not be 100 percent effective because small "daughter" cysts can be left behind. Chemotherapy (e.g., albendazole [Albenza] and mebendazole [Vermox]) (2,6) is effective against tapeworm disease, and its use is indicated for the treatment of patients with inoperable disease or as presurgical and postsurgical treatment to reduce the risk of recurrence. (7) Ultrasonographic or computed tomographic (CT)--guided fine-needle aspiration of hydatid cyst contents followed by infusion of a killing agent, such as 95 percent ethanol, and reaspiration, known as PAIR therapy (Puncture, Aspiration, Injection, Reaspiration), (3,11,12) has been used successfully at some centers but carries a risk of dissemination of infection or anaphylactic reaction caused by cyst puncture and leakage. (2,3,13)

The following case is an example of the presentation, diagnosis, and treatment of echinococcosis.

Illustrative Case

A 48-year-old man who moved to the United States three years ago from Bosnia presented to a physician's office for an initial physical examination. The patient reported a medical history of kidney stones diagnosed and treated in Bosnia in 1995, and elevated cholesterol levels. The patient's urine was positive for nonhemolyzed blood and a trace of protein. Urine culture and sensitivity were negative. Three months later, the patient presented with pelvic pain and the passage of a clot and a small stone fragment in his urine. At that point, the patient was scheduled for renal ultrasonography and a 24-hour urine collection for further work-up. Renal ultrasonography showed a normal right kidney, but the left kidney demonstrated a multicystic, septated complex area, mainly in the middle and lower portion, measuring approximately 9 cm 3 4 cm 3 5 cm.

The possibility of a congenital anomaly was considered. A CT scan of the abdomen showed normal liver, gallbladder, pancreas, and spleen. A dumbbell-shaped, fluid-filled, multiseptated structure appeared in the middle portion of the left kidney (Figure 1). Diagnostic considerations were expanded to include cystic nephroma, multicystic renal cell carcinoma, or hydatid disease. Serologic testing for antibodies to Echinococcus was positive. A CT scan of the chest was negative for additional cysts.

The patient opted for surgical drainage under ultrasound guidance. The procedure failed, so the patient opted for a radical nephrectomy (Figure 2), which was performed without any complications.

Prevention

Accidental ingestion of garden vegetables, water, or soil contaminated with tapeworm eggs from dog feces initiates this infection, (12,13) so it is important to educate populations in endemic areas about careful washing of hands and food. The feeding of livestock entrails to dogs is a common starting point for the tapeworm life cycle and should be avoided. (13) Educational programs should be initiated early because, presumably, most infections are acquired in childhood. (2,13,15)

The author thanks Dr. Thomas Rosenthal for reviewing the manuscript, and Drs. Peter Schantz, Kennon Miller, and James Woytash for their assistance.

Figure 1 courtesy of the Radiology Department, Erie County Medical Center, Buffalo, N.Y. Figure 2 courtesy of James Woytash, M.D., D.D.S., Erie County Medical Center.

The author indicates that he does not have any conflicts of interest. Sources of funding: none reported.

REFERENCES

(1.) Mandell GL, Douglas RG, Bennett JE, Dolin R. In: Mandell, Douglas, and Bennett's Principles and practice of infectious diseases. 5th ed. Philadelphia: Churchill Livingstone, 2000:2956-65.

(2.) Kammerer WS, Schantz PM. Echinococcal disease. Infect Dis Clin North Am 1993;7:605-18.

(3.) Ammann RW, Eckert J. Cestodes. Echinococcus. Gastroenterol Clin North Am 1996;25:655-89.

(4.) Webster GA, Cameron TW. Epidemiology and diagnosis of echinococcosis in Canada. Can Med Assoc J 1967;96:600-7.

(5.) Cook GC, Manson P. Manson's Tropical diseases. 20th ed. Philadelphia: Saunders, 1996:1494-501.

(6.) Franchi C, Di Vico B, Teggi A. Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates. Clin Infect Dis 1999;29:304-9.

(7.) Eckert J, Deplazes P. Alveolar echinococcosis in humans: the current situation in Central Europe and the need for countermeasures. Parasitol Today 1999;15:315-9.

(8.) Gabriele F, Bortoletti G, Conchedda M, Palmas C, Ecca AR. Epidemiology of hydatid disease in the Mediterranean basin with special reference to Italy. Parassitologia 1997;39:47-52.

(9.) Schantz PM. Effective medical treatment for hydatid disease? JAMA 1985;253:2095-7.

(10.) D'Alessandro A. Polycystic echinococcosis in tropical America: Echinococcus vogeli and E. oligarthrus. Acta Trop 1997;67:43-65.

(11.) Hunter GW, Strickland GT. Hunter's Tropical medicine and emerging infectious diseases. 8th ed. Philadelphia: Saunders, 2000:866-76.

(12.) Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis. Bull World Health Organ 1996;74:231-42.

(13.) Garcia LS, Bruckner DA. Tissue cestodes: larval forms. In: Diagnostic medical parasitology. 4th ed. Washington, D.C.: ASM Press, 2001:387-403.

(14.) Firpi RJ, Lozada LR, Torres EA, Villamarzo G, Lobera A. Fine-needle aspiration diagnosis of hydatid cyst. P R Health Sci J 1999;18:129-31.

(15.) Gorbach SL, Bartlett JG, Blacklow NR. Infectious diseases. 2d ed. Philadelphia: Saunders, 1998: 2493-6.

MILAD CHRIEKI, M.D., is clinical assistant professor of family medicine at the State University of New York (SUNY) at Buffalo School of Medicine and Biomedical Sciences, Buffalo, N.Y., and medical director of the Cleve-Hill Family Health Center, also in Buffalo. Dr. Chrieki completed his medical degree at Lvov State Medical University, Lvov, Ukraine, and completed a residency at the SUNY at Buffalo School of Medicine and Biomedical Sciences.

Address correspondence to Milad Chrieki, M.D., 71 Freemont Ave., Depew, NY 14043 (e-mail: chrieki@acsu.buffalo.edu). Reprints are not available from the author.

COPYRIGHT 2002 American Academy of Family Physicians
COPYRIGHT 2002 Gale Group

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