Midazolam chemical structure
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Versed

Midazolam, also known by the trade names Versed®, Hypnovel® and Dormicum®, is a benzodiazepine drug with an imidazole structure. Used commonly as an anxiolytic, amnestic, hypnotic and sedative, this medication provides an effect similar to diazepam, but with a quicker onset and shorter duration. It was first synthesized in 1976 by Fryer and Walser. more...

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This medication is frequently used (often in combination with other agents) by anesthesiologists for sedating patients prior to surgery, as well as for other invasive medical procedures such as colonoscopy.

Unlike other benzodiazepines such as diazepam and lorazepam, midazolam is water soluble as the imidazole ring is open at low pH. When it is in a solution with a pH greater than 4, the imidazole ring closes and it becomes much more lipid soluble, facilitating its rapid uptake into nerve tissue. This partly accounts for its rapid onset of action and its high protein binding in the blood (up to 97%).

Midazolam is a Schedule IV drug under the Convention on Psychotropic Substances. This drug is considered quite addictive , as expected given its potent anxiolytic properties and rapid onset of action. For these reasons, it is rarely prescribed outside hospital environments.

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The Great Passion: An Introduction to Karl Barth's Theology
From Christian Century, 11/29/05 by Jonathan Tran

The Great Passion: An Introduction to Karl Barth's Theology.

By Eberhard Busch. Eerdmans, 312 pp., $29.00.

Reading Karl Barth: New Directions for North American Theology.

By Kurt Anders Richardson. Baker, 256 pp., $21.99 paperback.

Karl Barth: Theologian of Christian Witness.

By Joseph L. Mangina. Ashgate, 224 pp., $29.95 paperback.

If the term panentheism can be stretched to cover versions of theism in which God retains some degree of independence from the world and is affected by it only through some kind of self-limitation, it becomes too thin. A few of the authors appeal to such a divine self-limitation as the basis for the world's being in God. They would do better to call their theory a revised theism or (in the case of the Eastern Orthodox theologians) an emphasis on God's immanence that is consistent with classical theism.

Expressivist panentheism is associated especially with the thought of German idealist philosophers, such as G. W. F. Hegel, and their heirs. It views God as coming to self-realization through the temporal processes of nature and history. Apart from a qualified endorsement by Clayton (who nonetheless finds the label unhelpful), this type of panentheism finds little support among these authors. Dipolar panentheism, finally, is the most common type in contemporary Christian theology because of its association with process thought. It sees God as receiving concrete being (that is, experienced life) from the world while possessing an eternal, primordial and abstract nature that is independent of the world. Several authors incline toward some variety of this form of panentheism.

One important issue raised by real panentheism (the expressivist and dipolar versions) is that of grace. If God is dependent on the world and in any sense needs the world, what becomes of grace? Is grace not then exhausted in nature (in the metaphysical sense)? Self-identified panentheists of all three varieties who consider themselves Christians need to wrestle with this issue more explicitly. Grace beyond nature would seem to be indispensable to the gospel; a relationship with a God who is essentially tied to the world does not seem to be one of grace. This is why the church fathers introduced the idea of creatio ex nihilo, which is barely touched on in this book. The redemption of a world without which God cannot be fully God is redemption not by grace but by necessity.

NEARLY 50 YEARS after Karl Barth uttered the words He will reign' and breathed his last, his work has returned to the center of theological discourse. Three recent introductions portray his theology as an event that jarred the world awake by announcing "God!" elegantly, powerfully and persuasively in a time when "man" had become the biggest show in town.

Eberhard Busch set the standard for telling the story of Barth in his biography Karl Barth: His Life from Letters and Autobiographical Texts, and now he sets a new standard for outlining the story that Karl Barth told. According to Busch, Barth's theology witnesses to the humanity of God in Christ, a story that both challenges anthropocentric theology and champions God's anthropocentrism.

A misreading of Barth's theology as primarily a disavowal of his liberal contemporaries misses the forest for the trees. Barth's central argument extols the witness of scripture to the God who acts for us. Barth's contempt for liberalism should be understood as secondary to his account of the story of God, who from eternity remains relentlessly anthropocentric in Jesus Christ. Barth did not see the problems of his age and then construct a positive theology in response to them; rather, the biblical witness was his starting point. In Busch's account of Barth's theology we uncover nothing less than the tragic drama of the Christian West.

Busch worked for years as Barth's assistant, and only someone so familiar with the theologian could offer the rare combination of exquisite scholarship and a voice that so closely matches Barth's. Whereas most Barthians fail in their attempts to reiterate Barth (Yale theologian Hans Frei characterized these efforts as "painfully boring"), Busch exemplifies, explains and extends Barth's "great passion."

Busch subtly but forcefully responds to the major readings and critiques of Barth while presenting Barth's work as theologically vital for contemporary Christian concerns. His restatement of Barth's odium for Christendom is a stinging critique of modern church-growth strategies. Simply put, there may be no better book on Barth.

In Reading Karl Barth, Kurt Anders Richardson, who teaches theology at McMaster University in Canada, does his most productive work in articulating how Barth invigorates orthodox christological formulas in order to construe human existence in terms of pilgrimage. Richardson highlights those moments in Church Dogmatics where Barth's Christology grounds human knowledge of God in God's action. God in Christ thus becomes both the content of human knowledge and the condition of possibility for such knowledge.

In Barth's day, it had become a given that in order for theology to go forward, it first had to legitimate its claims in something more substantial than the biblical witness. Barth, however, came to realize that such presumptions were atheistic: they assumed that there is a greater truth than the God witnessed in scripture.

Richardson goes to great lengths, sometimes circuitously, to guard against readings of Barth that make him too Roman Catholic, postmodern or socially liberal. The problem of such a project is that it betrays the very pilgrim theology Richardson so beautifully envisions. Making Barth safe for evangelicals domesticates Barth while insulating North American evangelicalism from the always-reforming potency that makes Protestantism a gift to the church.

Joseph Mangina's Karl Barth: Theologian of Christian Witness is best for readers engaging Barth for the first time, if for no other reason than that its stated goal is "to wean the student from the secondary literature as quickly as possible, and to move her along toward an actual engagement with Barth." The central five chapters focus on five core themes of the Dogmatics, and each concludes with a discussion by an interlocutor--Stanley Hauerwas, for example, for the chapter on creation.

Mangina orients the reader to the rich theological, philosophical and political world from which Barth emerged and to which he wrote and locates Barth's influence within contemporary theology. Like Busch and Richardson a teacher of theology, Mangina tells the same grand story of God's eternal reconciling act for humanity, but less elegantly than Busch and less contentiously than Richardson. Like the other two he offers superb discussions of the major themes of the Dogmatics. His summaries are straightforward and provocative, clear but not overly simple. One could not ask for a better text to introduce theology students to Barth's work, and even for the well-versed Barth reader, Magina's presentation is fresh, astute and appealing.

Reviewed by Jonathan Tran, a doctoral student in theology at Duke University.

COPYRIGHT 2005 The Christian Century Foundation
COPYRIGHT 2005 Gale Group

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